I took Betamethasone and slept 9 continuous hours incrediby

[DonPapotti]

Hi good day. Well, did something similar happen to someone?
They were only 2 times, maybe it was coincidence, but before I had trouble sleeping so many hours, and insomnia.
Maybe because of the systemic inflammation that came to the brain, among other things.
Thanks in advance.
PS: The curious and contradictory thing is that I read that they generate insomnia

[Marcia K]

Hello. I have never taken it so I'm no help there but I have sleeping issues as well. I'm happy if I can get 6 hours sleep, but that's rare.

[tex]

Don,

That's an abnormal response to a steroid. Steroids boost cortisol levels, so they typically make sleep more difficult. But if someone has been kept awake by pain, and the steroid relieves that pain, I can see how someone might sleep longer.


Marcia,

Before MC, I was an 8-hour sleeper. Once my symptoms started, my sleep time dropped to 4–6 hours. I've been in remission for over 14 years now, and I sleep about 5–6 hours (or less), so maybe it comes with the turf.

Tex

[Marcia K]

Hi, Tex. I'm okay with six hours if I sleep straight through the night. Sometimes I wake up at 1:30, which I attribute to work stress. But I feel okay on six hours so it's not a big issue for me. I don't necessarily like being up so early on vacation, etc. but it is what it is. Us Potty People learn to go with the flow!

[DonPapotti]

Hello. I have never taken it so I'm no help there but I have sleeping issues as well. I'm happy if I can get 6 hours sleep, but that's rare.

The same happens to me!
I am taking antihistamines, because I wake up sometimes at 2.30am ... at 2am .... 3.30.
PS: The corticosteroids were coincidence.

How many years have you been diagnosed Marcia and Tex?
I read that I sleep less than 6 hours a day, and fragmentedly it is a risk factor to develop neurodegenerative diseases. Since beta-amyloid accumulates in the brain.
tex you have a deviated septum nasal? And your marcia, ?
Of course it depends on more factors, but I'm afraid of that ... although I think I'll die before developing that. Although nobody knows our destiny ..

[tex]

As I've posted many, many times here over the last 14 years since I created this forum, I was never officially diagnosed with MC, because my original GI doc didn't take any biopsies during my original colonoscopy (in the year 2000, after my symptoms began). He was so sure that I had cancer, that he never even gave me a celiac screening test. After I had all the (other) tests that he could think of, he told me that there was nothing wrong with me (despite the fact that I was as sick as a dog). I had to figure out the problem and resolve it myself, without any medical help. But that's how breakthrough discoveries are made.

I tried to live with it for a couple of years, but my symptoms were so bad that I couldn't live like that, so I started researching it in online medical journals. After a few months I decided that I must be sensitive to gluten, so I cut that out of my diet and never touched it again. After a few months without gluten, I was able to test other foods and detect whether of not they made me react. It took me almost two years of trial and error testing to figure out all the additional foods were causing me to react, but when I cut all those foods out of my diet, I was in remission within about two weeks. I've been in remission ever since (15 years), except for accidental exposures to contaminated foods, and an episode of kidney stones (a number of years ago) that triggered a relapse of symptoms.

Note that the lack of an official medical diagnosis of MC has never been a problem. I've had three hospitalizations since the onset of symptoms (over the years, for non-MC issues), and no doctor has ever questioned (let alone disputed) my MC status when I inform them why I require a special diet. Probably, they are intimidated by the fact that they know very little about the disease and how to treat it, so they don't care to talk about it, anyway.

I have no idea whether I have a deviated septum. I'm pretty sure that I don't have any accumulations of beta-amyloid in my brain because I have rare genetics that make me immune to Creutzfeldt-Jakob disease (which also makes me immune to mad cow disease), so I'm pretty sure that I'm immune to Alzheimer's disease, also.

That said, I was officially diagnosed with Parkinson's disease ten year ago. But I was undiagnosed a year later, after I convinced another neurologist that I couldn't have it (and I don't have it). I'm convinced that neurodegenerative diseases are caused by years of vitamin D and/or magnesium deficiency.

Here's a quote from pages 222–224 of Understanding Microscopic Colitis

The brain fog that often develops with MC may have a sinister side.
MC appears to be associated with neurodegenerative diseases such as Alzheimer's, Parkinson's and amyotrophic lateral sclerosis, (ALS). This association hasn't yet been proven, but all of these diseases seem to have a gastrointestinal connection. For example, patients who have Parkinson's disease have been shown to have different gut biomes than people who do not have the disease. Furthermore, Parkinson's patients have been shown to have had gastrointestinal issues decades before their Parkinson's symptoms developed.

According to The Michael J Fox Foundation, almost 80 % of Parkinson's patients have constipation that usually begins several years prior to the development of Parkinson's symptoms (Dolhun, 2014, December 08).252 Furthermore, not only do Parkinson's patients have altered gut biomes, but Parkinson's patients with different types of motor symptoms, have unique populations of gut bacteria that coordinate with the types of symptoms. For example, Parkinson's patients with more severe balance and gait problems have more Enterobacteria than others.

All Parkinson's patients have fewer Prevotella bacteria than normal people (Ghaisas, Maher, & Kanthasamy, 2016).253 So do autistic children, incidentally. Interestingly, in normal people, this bacterium usually helps to produce thiamine and folate vitamins. Perhaps this is a clue.

The Michael J Fox Foundation also points out that a protein that's found in clumps in the brains of all Parkinson's disease patients (known as alpha-synuclein) can be found in certain other locations in the body outside of the brain, including the enteric nervous system —the nerves that control the digestive system, sometimes called the second brain (Dolhun, 2014, December 08). The question yet to be answered is whether alpha-synuclein might develop first in the gut and then eventually spread to the brain where it causes motor symptoms.

Recalling part of our discussion back in chapter 3, we know that Parkinson's patients have lower vitamin D levels than people who don't have Parkinson's, (Kwon et al., 2016). And we know that vitamin D deficiency may be a common cause of delayed gastric emptying in untreated Parkinson's patients (Kwon et al., 2016). And as discussed previously, we recognize that magnesium deficiency might also contribute to delayed stomach emptying.

Could these neurodegenerative diseases be consequences of decades of chronic vitamin D and magnesium deficiencies?
Looking at the associations of neurodegenerative diseases with decades of digestive disorders that are often connected with, and may be caused by vitamin D and magnesium deficiencies, suggests to me that these syndromes may not be diseases — they might be symptoms of ignoring chronic vitamin D and magnesium deficiencies for decades.

The brain fog that's often associated with MC certainly illustrates the ability of digestive system inflammation to cause serious neurological problems. And the fact that resolving MC symptoms resolves brain fog suggests that resolving these chronic deficiencies may be the key to preventing the development of neurodegenerative diseases.

If the deficiencies continue to remain untreated as the decades pass, then whether or not a neurodegenerative disease may develop is likely to be determined by the individual's predisposing genes. In other words, genetics will determine which type or types of neurodegenerative issues may develop due to unresolved nutrient deficiencies. At this point, this is strictly a theory. Time will tell whether or not it will eventually be proven by medical researchers to be valid.

In support of my theory, however, I would point out that magnesium has been shown to prevent the clumping of alpha-synuclein (Golts et al., 2002).254 So a chronic magnesium deficiency would surely allow a buildup of clumps of alpha-synuclein.

Here are the medical references from that quote:

252 Dolhun, R. (2014, December 08). Gut check on Parkinson's: New findings on bacteria levels. Retrieved from https://www.michaeljfox.org/foundation/ ... ria-levels

253 Ghaisas, S., Maher, J., & Kanthasamy, A. (2016). Gut microbiome in health and disease: Linking the microbiome-gut-brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative diseases. Pharmacology & Therapeutics, 158, 52–62. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747781/

254 Golts, N., Snyder, H., Frasier, M., Theisler, C., Choi, P., & Wolozin, B. (2002). Magnesium inhibits spontaneous and iron-induced aggregation of alpha-synuclein. Journal of Biological Chemistry, 277(18), 16116–16123. Retrieved from http://www.jbc.org/content/277/18/16116.long

Tex

[Marcia K]

Hi, Don. I was diagnosed in 2013 after a colonoscopy. I was fortunate, I had a colonoscopy scheduled due to my age when the D started so I was only ill for a few weeks before I had a diagnosis. I had a deviated septum repaired about 15 years ago.

[DonPapotti]

Tex there are several factors that can cause neurodegenerative diseases.
Once I read that toxic substances that are in fish can also generate it.
Unfortunately in modern society almost nobody is free of this.
I read that the gold standard for neurodegenrativas is brain biopsy, but it is not done because it is invasive.
It's done by resonance, I think. Probably the one who told you that you had Alzheirmer is a mediocre doctor.
Thank you for your answers.