IBS has it been finally figured out???

[Erica P-G]

There was very intriguing information in this article, enough so that some of it may need more researching for each of us individually.


https://chriskresser.com/is-ibs-an-auto ... i=74711087

[tex]

Interesting. I have a hunch that this all started with the research mentioned in this quote from pages 263—264 of Understanding Microscopic Colitis, but Chris doesn't appear to list it as a reference (unless I overlooked it):

Perhaps the most important research concerning the development of inflammatory bowel disease to be published in decades focuses on a series of minor food poisoning events that may cause cumulative damage that leads up to the development of IBD.
Yang et al. (2017) showed that relatively minor food poisoning events involving a very common bacteria, Salmonella Typhimurium, can lead to a series of events that culminate in the development of IBD.334 The researchers showed that this can happen even when the infection is so mild that there are no significant symptoms and the Salmonella are easily eliminated by the immune system. In the study, four repeated infections were sufficient to cause the development of IBD.

Yang et al. (2017) noted that the Salmonella induced an acquired deficiency of intestinal alkaline phosphatase (IAP), an enzyme that is normally produced by the small intestine to remove phosphates from molecules such as the lipopolysaccharide (LPS) byproducts of various bacteria normally found in the colon. The IAP deficiency allows LPS to remain in a toxic, pro-inflammatory form.

This leads to a state of chronic inflammation that tends to be reinforced by repeated minor infections, and eventually the result is IBD. Perhaps in the future, IAP levels can be monitored, and if a deficiency is detected, it can be supplemented to prevent the development of IBD.

Here's reference 334 from that quote:

334. Yang, W. H., Heithoff, D. M., Aziz, P. V., Sperandio, M., Nizet, V., Mahan, M. J., & Marth, J. D. (2017). Recurrent infection progressively disables host protection against intestinal inflammation Science, 358(6370), eaao5610 Retrieved from http://science.sciencemag.org/content/358/6370/eaao5610

Thanks for the link. Chris Kressor always seems to be on top of new developments.

Tex

[Erica P-G]

Wow Tex, give or take a couple words and that title is almost verbatim

I did not catch reference to your book either. I am glad to see that this is getting dug into deeper.....I'm sure our Biome is getting disrupted and to an extent it is causing more issues for way more people now.