here are my test results but I have a question first: What is Transglutaminase? It says I have an autoimmune reaction to the human enzyme tissue transglutaminase, secondary to dietary gluten sensitivity.
A) Gluten Sensitivity Stool and Gene Panel Complete *Best test/best value
Fecal Antigliadin IgA 40 (Normal Range <10 Units)
Fecal Antitissue Transglutaminase IgA 16 Units (Normal Range <10 Units)
Quantitative Microscopic Fecal Fat Score 109 Units (Normal Range <300 Units)
Fecal anti-casein (cow's milk) IgA antibody 15 Units (Normal Range <10 Units)
HLA-DQB1 Molecular analysis, Allele 1 0201
HLA-DQB1 Molecular analysis, Allele 2 0201
Serologic equivalent: HLA-DQ 2,2 (Subtype 2,2)
C) Egg, Yeast, and Soy Food Sensitivity Stool Panel
Fecal anti-ovalbumin (chicken egg) IgA antibody 5 Units (Normal Range <10 Units)
Fecal Anti-Saccharomyces cerevisiae (dietary yeast) IgA 6 Units (Normal Range <10 Units)
Fecal Anti-Soy IgA 6 Units (Normal Range <10 Units)
Acute/Chronic Colitis Stool Test
Fecal lactoferrin (Normal - Negative)
And if you are interested the detailed results:
Interpretation of Fecal Antigliadin IgA: Intestinal antigliadin IgA antibody was elevated, indicating that you have active dietary gluten sensitivity. For optimal health, resolution of symptoms (if you have them), and prevention of small intestinal damage and malnutrition, osteoporosis, and damage to other tissues (like nerves, brain, joints, muscles, thyroid, pancreas, other glands, skin, liver, spleen, among others), it is recommended that you follow a strict and permanent gluten free diet. As gluten sensitivity is a genetic syndrome, you may want to have your relatives screened as well.
Interpretation of Fecal Antitissue Transglutaminase IgA: You have an autoimmune reaction to the human enzyme tissue transglutaminase, secondary to dietary gluten sensitivity.
Interpretation of Quantitative Microscopic Fecal Fat Score: A fecal fat score less than 300 indicates there is no malabsorbed dietary fat in stool indicating that digestion and absorption of nutrients is currently normal.
Interpretation of Fecal anti-casein (cow's milk) IgA antibody: Levels of fecal IgA antibody to a food antigen greater than or equal to 10 are indicative of an immune reaction, and hence immunologic "sensitivity" to that food. For any elevated fecal antibody level, it is recommended to remove that food from your diet. Values less than 10 indicate there currently is minimal or no reaction to that food and hence, no direct evidence of food sensitivity to that specific food. However, because 1 in 500 people cannot make IgA at all, and rarely, some people can still have clinically significant reactions to a food antigen despite the lack of a significant antibody reaction (because the reactions primarily involve T cells), if you have an immune syndrome or symptoms associated with food sensitivity, it is recommended that you try a strict removal of suspect foods from your diet for up to 12 months despite a negative test.
Interpretation Of HLA-DQ Testing: HLA gene analysis reveals that you have two copies of the main genes that predispose to gluten sensitivity and celiac sprue, HLA-DQ2 or HLA-DQ8. Having two copies of a gluten sensitive or celiac gene means that each of your parents, and all of your children (if you have them) will possess at least one copy of the gene. Two copies also means there is an even stronger predisposition to gluten sensitivity than having one gene and the resultant immunologic gluten sensitivity or celiac disease may be more severe.
Interpretation of Fecal anti-ovalbumin (chicken egg) IgA antibody: Levels of fecal IgA antibody to a food antigen greater than or equal to 10 are indicative of an immune reaction, and hence immunologic "sensitivity" to that food. For any elevated fecal antibody level, it is recommended to remove that food from your diet. Values less than 10 indicate there currently is minimal or no reaction to that food and hence, no direct evidence of food sensitivity to that specific food. However, because 1 in 500 people cannot make IgA at all, and rarely, some people can still have clinically significant reactions to a food antigen despite the lack of a significant antibody reaction (because the reactions primarily involve T cells), if you have an immune syndrome or symptoms associated with food sensitivity, it is recommended that you try a strict removal of suspect foods from your diet for up to 12 months despite a negative test.
Interpretation of Fecal Anti-Saccharomyces cerevisiae (dietary yeast) IgA: Levels of fecal IgA antibody to a food antigen greater than or equal to 10 are indicative of an immune reaction, and hence immunologic "sensitivity" to that food. For any elevated fecal antibody level, it is recommended to remove that food from your diet. Values less than 10 indicate there currently is minimal or no reaction to that food and hence, no direct evidence of food sensitivity to that specific food. However, because 1 in 500 people cannot make IgA at all, and rarely, some people can still have clinically significant reactions to a food antigen despite the lack of a significant antibody reaction (because the reactions primarily involve T cells), if you have an immune syndrome or symptoms associated with food sensitivity, it is recommended that you try a strict removal of suspect foods from your diet for up to 12 months despite a negative test.
Interpretation of Fecal Anti-Soy IgA: Levels of fecal IgA antibody to a food antigen greater than or equal to 10 are indicative of an immune reaction, and hence immunologic "sensitivity" to that food. For any elevated fecal antibody level, it is recommended to remove that food from your diet. Values less than 10 indicate there currently is minimal or no reaction to that food and hence, no direct evidence of food sensitivity to that specific food. However, because 1 in 500 people cannot make IgA at all, and rarely, some people can still have clinically significant reactions to a food antigen despite the lack of a significant antibody reaction (because the reactions primarily involve T cells), if you have an immune syndrome or symptoms associated with food sensitivity, it is recommended that you try a strict removal of suspect foods from your diet for up to 12 months despite a negative test.
If you read this far... thank you!
Got my test results back today!
Moderators: Rosie, Stanz, Jean, CAMary, moremuscle, JFR, Dee, xet, Peggy, Matthew, Gabes-Apg, grannyh, Gloria, Mars, starfire, Polly, Joefnh
Got my test results back today!
Dr Fine test shows positive for gluten and casien but negative for soy, eggs, and yeast
Maybe its UC maybe its MC? Who knows at this point, but at least I know my intollerances now... so heres to the road to healing!
Maybe its UC maybe its MC? Who knows at this point, but at least I know my intollerances now... so heres to the road to healing!
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barbaranoela
- Emperor Penguin
- Posts: 5394
- Joined: Wed May 25, 2005 6:11 pm
- Location: New York
Yes, I read the entire posting---as I am sure everyone here will--
I have to add---I am somewhat clueless to these #'s ---
I now think to myself----I never got/better still never knew what to ASK for----
But then I never did Dr. Fine's test~~~so I guess that Xplains my ignorance in this issue of our disease---
And I never knew of all this stuff until I got to this board and started reading---
So know what road are U going to follow???
Curious, Barbara
I have to add---I am somewhat clueless to these #'s ---
I now think to myself----I never got/better still never knew what to ASK for----
But then I never did Dr. Fine's test~~~so I guess that Xplains my ignorance in this issue of our disease---
And I never knew of all this stuff until I got to this board and started reading---
So know what road are U going to follow???
Curious, Barbara
the fruit of the spirit is love, joy, peace, patience, kindness, goodness, faithfulness and self-control
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annie oakley
- King Penguin
- Posts: 3859
- Joined: Fri May 13, 2011 5:56 pm
I will be going gluten and milk free since I am intollerant of gluten and casien. This will start after my honeymoon in May.
Dr Fine test shows positive for gluten and casien but negative for soy, eggs, and yeast
Maybe its UC maybe its MC? Who knows at this point, but at least I know my intollerances now... so heres to the road to healing!
Maybe its UC maybe its MC? Who knows at this point, but at least I know my intollerances now... so heres to the road to healing!
Hi Andrew,
Basically, transglutaminases are enzymes that catalyze the formation of a covalent bond between a free amine group (for example, protein- or peptide-bound lysine) and the gamma-carboxamid group of protein- or peptide bound glutamine.
Transglutaminases form protein polymer chains that are extensively cross linked and generally insoluble. They are useful for blood clotting, growing skin, and hair, and many other vital processes.
Neurological diseases like Huntington's, Parkinson's, and Alzheimer's, have been linked with unusually high levels of transglutaminases.
For our purposes, though, it provides a convenient test for gluten sensitivity:
http://www.ncbi.nlm.nih.gov/entrez/quer ... t=Abstract
Looking at your test scores, you are clearly gluten sensitive, thought your fecal fat score indicates a lack of significant damage to your small intestine, so you are probably not a celiac, even though your DNA test shows that you have the celiac gene, apparently two copies of it.
I see that you are intolerant of casein, but your egg, yeast, and soy results were all negative.
I find it very interesting that your Acute/Chronic Colitis Stool Test result was negative, (fecal lactoferrin level was normal). Apparently you did not have any inflammation when you took the sample. Did you have any diarrhea at the time? IOW, fecal lactoferrin can be used as a marker for fecal leukocytes, to detect the presence of active inflammatory bowel disease. Here's a reference for that:
http://tinyurl.com/r9lfg
It's no wonder that you are in no particular hurry to begin the diet, because evidently, your MC is currently not active. You appear to be the lucky victim of a spontaneous remission. How long it will last, is anybody's guess.
Thanks for posting the information.
Tex
Basically, transglutaminases are enzymes that catalyze the formation of a covalent bond between a free amine group (for example, protein- or peptide-bound lysine) and the gamma-carboxamid group of protein- or peptide bound glutamine.
Transglutaminases form protein polymer chains that are extensively cross linked and generally insoluble. They are useful for blood clotting, growing skin, and hair, and many other vital processes.
Neurological diseases like Huntington's, Parkinson's, and Alzheimer's, have been linked with unusually high levels of transglutaminases.
For our purposes, though, it provides a convenient test for gluten sensitivity:
http://www.ncbi.nlm.nih.gov/entrez/quer ... t=Abstract
Looking at your test scores, you are clearly gluten sensitive, thought your fecal fat score indicates a lack of significant damage to your small intestine, so you are probably not a celiac, even though your DNA test shows that you have the celiac gene, apparently two copies of it.
I see that you are intolerant of casein, but your egg, yeast, and soy results were all negative.
I find it very interesting that your Acute/Chronic Colitis Stool Test result was negative, (fecal lactoferrin level was normal). Apparently you did not have any inflammation when you took the sample. Did you have any diarrhea at the time? IOW, fecal lactoferrin can be used as a marker for fecal leukocytes, to detect the presence of active inflammatory bowel disease. Here's a reference for that:
http://tinyurl.com/r9lfg
It's no wonder that you are in no particular hurry to begin the diet, because evidently, your MC is currently not active. You appear to be the lucky victim of a spontaneous remission. How long it will last, is anybody's guess.
Thanks for posting the information.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Hey Tex,
I like your new picture. I thought that the lactoferrin being negative means that I dont have ulcerative colitis or crohns disease but does not necessarily rule out MC. I have never had visible inflammation in my colonoscopies, but biopsies showed mild inflammation. I am taking Entocort Ec which I hear is very effective against MC so maybe that is why I didnt have any inflammation at the time. I am not sure if I was having diarrhea at the time because I take imdoium on a regular basis now to keep me from going to the bathroom a lot during work since I cant be in the jon the whole day or else no one would get their taxes done!
I am glad that I finally know what foods to cut out of my diet and I guess that means no mashed potatoes with cows milk. Do you know if sheeps and goats milk is ok? I wanted to talk to Dr Fine today but he was out of town this week, so I guess I will have to wait until next week to talk to him.
I like your new picture. I thought that the lactoferrin being negative means that I dont have ulcerative colitis or crohns disease but does not necessarily rule out MC. I have never had visible inflammation in my colonoscopies, but biopsies showed mild inflammation. I am taking Entocort Ec which I hear is very effective against MC so maybe that is why I didnt have any inflammation at the time. I am not sure if I was having diarrhea at the time because I take imdoium on a regular basis now to keep me from going to the bathroom a lot during work since I cant be in the jon the whole day or else no one would get their taxes done!
I am glad that I finally know what foods to cut out of my diet and I guess that means no mashed potatoes with cows milk. Do you know if sheeps and goats milk is ok? I wanted to talk to Dr Fine today but he was out of town this week, so I guess I will have to wait until next week to talk to him.
Dr Fine test shows positive for gluten and casien but negative for soy, eggs, and yeast
Maybe its UC maybe its MC? Who knows at this point, but at least I know my intollerances now... so heres to the road to healing!
Maybe its UC maybe its MC? Who knows at this point, but at least I know my intollerances now... so heres to the road to healing!
Wow Andrew, I hope you scanned, cut and pasted that!
I'm glad you shared the information. Since I've not had the test(s), I was unaware just how much information is given, very interesting.
If I might make a suggestion......or not..............
If you are aware that you are gluten and casen sensative, why not begin to cut back on the things you KNOW you are going to eliminate NOW so that you are feeling much better FOR your honeymoon! A few months can make a world of difference.
It gets easier to "eliminate" whatever you choose to eliminated from your diet as time goes on. It then becomes habit.
Good luck in your decision(s). Don't hesitate to ask questions, we're here to help. There are MANY knowledgeable people here who have already "been there, done that". But then again, we are always learning something new from one another!
Best wishes,
Mars
I'm glad you shared the information. Since I've not had the test(s), I was unaware just how much information is given, very interesting.
If I might make a suggestion......or not..............
If you are aware that you are gluten and casen sensative, why not begin to cut back on the things you KNOW you are going to eliminate NOW so that you are feeling much better FOR your honeymoon! A few months can make a world of difference.
It gets easier to "eliminate" whatever you choose to eliminated from your diet as time goes on. It then becomes habit.
Good luck in your decision(s). Don't hesitate to ask questions, we're here to help. There are MANY knowledgeable people here who have already "been there, done that". But then again, we are always learning something new from one another!
Best wishes,
Mars
"Let us rise up and be thankful, for if we didn't learn a lot today, at least we learned a little, and if we didn't learn a little, at least we didn't get sick, and if we got sick, at least we didn't die; so, let us all be thankful." -- Buddha
Hi Terps!
I know you must feel so much better finally knowing what the problem is. Yep, GF and CF it seems to be! Welcome (officially) to the food intolerance club.
I have read that some who can't tolerate cow's milk can do fine with sheep/goat milk. Alas, that is not the case with me. I have tried both with no luck. Sigh.
About those mashed potatoes - you will find some acceptable substitutes - some do well with the nut milks or with coconut milk, for example. I even learned to like them made with chicken broth. Some parents of autistic children have found that their kids improve on a GF/CF diet, BTW. There is a website with GF/CF recipe suggestions, if I remember correctly.
I had also had gluten intolerance without any significant fecal fat score (no small bowel damage). I guess that is something we can be thankful for - that we caught it early.
I would agree with those above who suggest starting the diet early - or at least easing into it. It might make your honeymoon much more enjoyable and stress-free.
Good luck. And ask any questions you have There are many here who have experience with GF/CF eating.
Love,
Polly
I know you must feel so much better finally knowing what the problem is. Yep, GF and CF it seems to be! Welcome (officially) to the food intolerance club.
I have read that some who can't tolerate cow's milk can do fine with sheep/goat milk. Alas, that is not the case with me. I have tried both with no luck. Sigh.
About those mashed potatoes - you will find some acceptable substitutes - some do well with the nut milks or with coconut milk, for example. I even learned to like them made with chicken broth. Some parents of autistic children have found that their kids improve on a GF/CF diet, BTW. There is a website with GF/CF recipe suggestions, if I remember correctly.
I had also had gluten intolerance without any significant fecal fat score (no small bowel damage). I guess that is something we can be thankful for - that we caught it early.
I would agree with those above who suggest starting the diet early - or at least easing into it. It might make your honeymoon much more enjoyable and stress-free.
Good luck. And ask any questions you have There are many here who have experience with GF/CF eating.
Love,
Polly
Blessed are they who can laugh at themselves, for they shall never cease to be amused.
My underrstanding is that that a negative result from a fecal lactoferrin test, indicates the absence of any inflammation, due to any type of IBD. It would not necessarily rule out either one of them, it merely indicates that none of them is currently active, including MC, (as of the date of the sample). In your case, yes, I would assume that the negative test result is very likely due to the Entocort.
If your colonoscopy exams have never revealed any signs of inflammation, visable to the naked eye, then I don't see how your doctor could have come up with a diagnisis of UC. UC is normally marked by visable gross evidence of inflammation and/or lesions.
Yep, mashed potratoes without milk and/or butter, really got on my nerves, for several years when I had to avoid all dairy products, but I just ate 'em dry. LOL.
Tex
If your colonoscopy exams have never revealed any signs of inflammation, visable to the naked eye, then I don't see how your doctor could have come up with a diagnisis of UC. UC is normally marked by visable gross evidence of inflammation and/or lesions.
Yep, mashed potratoes without milk and/or butter, really got on my nerves, for several years when I had to avoid all dairy products, but I just ate 'em dry. LOL.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
yeah I might ease into the diet but I dont want to go totally GF and CF before the honeymoon because I am going to Mexico and cant speak a lick of Spanish so I wont really be able to communicate my food intollerance nor would I be satisfied that they know exactly what is going on! I am doing well on teh Entocort and can eat just about anything (aside from drinking a glass of milk)!
I sure hope I can find a margarine that doesnt have gluten or milk... there has got to be one around.
And Yes I just copied the results from my email and pasted them on! Geez imagine if I did type all that!
I sure hope I can find a margarine that doesnt have gluten or milk... there has got to be one around.
And Yes I just copied the results from my email and pasted them on! Geez imagine if I did type all that!
Dr Fine test shows positive for gluten and casien but negative for soy, eggs, and yeast
Maybe its UC maybe its MC? Who knows at this point, but at least I know my intollerances now... so heres to the road to healing!
Maybe its UC maybe its MC? Who knows at this point, but at least I know my intollerances now... so heres to the road to healing!
Andrew,
There are some margarines around that are devoid of dairy ingredients, but they are the economy brands, and they are usually based on corn and/or soy. If you don't have a problem with corn or soy, you're all set. Just check the labels on the cheapest brands, until you find what you're looking for. There used to be some good canola margarines, but I'm not sure if they are still available.
Tex
There are some margarines around that are devoid of dairy ingredients, but they are the economy brands, and they are usually based on corn and/or soy. If you don't have a problem with corn or soy, you're all set. Just check the labels on the cheapest brands, until you find what you're looking for. There used to be some good canola margarines, but I'm not sure if they are still available.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
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artteacher
- Rockhopper Penguin
- Posts: 731
- Joined: Wed Aug 24, 2005 11:13 pm
.
Hi there,
I use Nucoa margerine . . .
Love, Marsha
I use Nucoa margerine . . .
Love, Marsha
Hi there,
It's late, so I'm a little mixed up. Was your dx UC? I remember that it's not impossible to have a positive lactoferrin with M.C., but that is more typical of UC and Crohn's.
Anyway, I'm so glad to see that, of the antigens you were tested for, that you only had two of them, although I'm sure that that sounds like a mountain to you at the moment, particularly with all you've got going on at the moment -- yipes, tax time AND a wedding!
I really need to make a separate post for this, but Dr. Fine's site has been redone with much more detail as to the whys and wherefores of the test results. Think you have to click onto the link that has Research in it to get this once you are in his site. Lots of information comes from the questions that Dr. Fine's been getting in response to test results, so I'm sure that you'll greatly benefit from reading the new site. I just got an e-mail thanking me for attending the conference recently in Dallas, and that's why I discovered everything's now very detailed with this new one.
Congratulations! I'm envious of your being able to eat eggs. One thing that may help you down in Mexico is that the more traditional, homemade tortillas are made from corn masa without the included wheat flour like most of the Tex-Mex restaurants seem to have these days.
I just have a hunch that corn won't be a problem for you, as it seems that the corn folks tend to have problems with more things than you tested positive for, but this is just a guess.
Thanks for posting your results!
Yours, Luce
It's late, so I'm a little mixed up. Was your dx UC? I remember that it's not impossible to have a positive lactoferrin with M.C., but that is more typical of UC and Crohn's.
Anyway, I'm so glad to see that, of the antigens you were tested for, that you only had two of them, although I'm sure that that sounds like a mountain to you at the moment, particularly with all you've got going on at the moment -- yipes, tax time AND a wedding!
I really need to make a separate post for this, but Dr. Fine's site has been redone with much more detail as to the whys and wherefores of the test results. Think you have to click onto the link that has Research in it to get this once you are in his site. Lots of information comes from the questions that Dr. Fine's been getting in response to test results, so I'm sure that you'll greatly benefit from reading the new site. I just got an e-mail thanking me for attending the conference recently in Dallas, and that's why I discovered everything's now very detailed with this new one.
Congratulations! I'm envious of your being able to eat eggs. One thing that may help you down in Mexico is that the more traditional, homemade tortillas are made from corn masa without the included wheat flour like most of the Tex-Mex restaurants seem to have these days.
I just have a hunch that corn won't be a problem for you, as it seems that the corn folks tend to have problems with more things than you tested positive for, but this is just a guess.
Thanks for posting your results!
Yours, Luce
Hey Luce-
No I think they ruled out UC because there was a negative lactoferrin. But at any rate I know that I will have to cut out gluten and dairy starting after the honeymoon in May. I am feeling physically pretty well now a days since I am on Entocort which supposedly really helps MCers... I can eat just about anything I want right now aside from a glass of milk. But I am going to stat cutting down drastically my intake of gluten and dairy after tax season so I can ease into the diet so it wont be such a shock when I come back from Mexico in May. Then I will have 1.5 months left of the Entocort which should be plenty of time to start feeling better after doing the diet for a month and a half...
Thanks for reading my post Luce!
Andrew
No I think they ruled out UC because there was a negative lactoferrin. But at any rate I know that I will have to cut out gluten and dairy starting after the honeymoon in May. I am feeling physically pretty well now a days since I am on Entocort which supposedly really helps MCers... I can eat just about anything I want right now aside from a glass of milk. But I am going to stat cutting down drastically my intake of gluten and dairy after tax season so I can ease into the diet so it wont be such a shock when I come back from Mexico in May. Then I will have 1.5 months left of the Entocort which should be plenty of time to start feeling better after doing the diet for a month and a half...
Thanks for reading my post Luce!
Andrew
Dr Fine test shows positive for gluten and casien but negative for soy, eggs, and yeast
Maybe its UC maybe its MC? Who knows at this point, but at least I know my intollerances now... so heres to the road to healing!
Maybe its UC maybe its MC? Who knows at this point, but at least I know my intollerances now... so heres to the road to healing!