Pepto Bismol Protocol

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KarenT
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Pepto Bismol Protocol

Post by KarenT »

Hi, I've been searching the forum for information about the Pepto Bismol Protocol, but I'm curious about what is the most current thoughts on it? I saw that it was considered safe but other folks seem well against it, these comments ranging over several years. To try, or not to try?
Karen
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tex
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Post by tex »

Here are my thoughts:

If you are searching for a way to make the diet work faster, the Pepto treatment is a good bet. If it works for you, the average time to remission is about two weeks. Over the years, many members have used it to gain remission. It doesn't work for everyone, (mostly due to side effect risks of tinnitus or neurological symptoms) but it's at least as effective as most stronger medications, including budesonide and mesalamine.

Tex
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It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
KarenT
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Post by KarenT »

Thank you, Tex. I did see some comments about a black tongue 😳 and black stool? Black tongue isn’t permanent, is it??
I hope you are well. 😊
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Post by tex »

Hi Karen,

No, the black tongue and black stool will return to normal after the treatment is ended.

Thanks, I seem to be doing well these days. Probably better than I deserve, at my age. :lol:

Tex
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It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
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Post by Pebbledash »

I wonder if there is any evidence that Pepto Bismol, in the long-run, might do as much harm as it does good?

I say this because I have been using it for about ten years, first as my only treatment (ill-informed consultant) and then as a very regular "top up." When it was my sole treatment, I probably got through nearly a bottle a day at times, and, even with Budesonide, I took pretty heavy doses pretty regularly.

However, I recently stopped it due to tinnitus (no proof that the tinnitus is related to Pepto Bismol, to be fair, but it felt right to stop it in the circumstances). To my surprise, I have been markedly better off since stopping the PB. I still take one Budesonide per day and have been significantly more systematic in my daily doses of cholestyramine.

Paul
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Post by KarenT »

Thanks again, Tex..... I have to say the thought of having a black tongue, long term, was a bit daunting! :-)

I am very glad to hear you are doing well. I, obviously, can't speak about your life outside of the forum, but with all of your good deeds regarding this forum and your mountain of knowledge that you so freely share you do deserve to be 'doing well'!

Paul, I have read about the possibility of tinnitus as a side effect of the PBP. One of the reasons I wanted opinions of the current thoughts regarding the protocol! I'm glad you are doing better!
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Post by tex »

Hi Paul,

Karen is right, of course, there's plenty of evidence that long-term use of bismuth subsalicylate (Pepto Bismol) is contraindicated. Not only tinnitus, but various neurological issues have been shown to be a risk when the subsalicylate accumulates because the body is unable to purge it fast enough. The original study (published in Gastroenterology in 1998) showed that 8 tablets per day for eight weeks was a safe treatment. Above and beyond that would be traveling in uncharted waters. Some people are able to handle longer term treatments, and some are not.

Then there's the age-old problem of induced tolerance. After long-term use of many (perhaps most) medications, the body develops a tolerance, and the medication begins to lose efficacy. Eventually, it may become a liability, as the efficacy disappears and only the undesirable side effects remain.

Tex
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It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
rcchild@gpcom.net
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Post by rcchild@gpcom.net »

Karen,
If you take the Pepto Bismol caplets, you won't have to worry about the black tongue. I tried them for a very short period of time and the WD got worse but, in my case, I think it is one or more of the inactive ingredients. If I try the protocol again, I will experiment with each type of Pepto Bismol (and Kaopectate which has the same amount of bismuth) and see if there is one I can tolerate. The inactive ingredients are different in each product.
For now I've decided to try cholestryramine. The inactive ingredients may be a problem with it also.
Keep us posted if you do the protocol. I'm very interested in how it works for you.
Carol C
KarenT
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Post by KarenT »

Thank you Carol! Currently I have the chewables but will get the caplets moving forward. I’ll let you know how it goes!
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Post by Pebbledash »

Thanks for the replies!

I wonder if there if there is more than just tolerance issues going on over a sustained period of use; whether, for instance, PB can impact the digestive tract's balance of bacteria, or something along those lines.

Pure speculation, of course, and based on only one month of being off the stuff. Just food for thought.

Cheers
Paul
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Post by tex »

Pepto Bismol has slight antibiotic attributes, so heavy, long-term use could possibly cause gut bacteria problems. That's another reason why it's not recommended for long-term use.

Tex
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It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
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Post by Marcia K »

Hi, Karen. I'm a Pepto success story (recommended by my GI when I was diagnosed). I took 2 tablets/4xday for 8 weeks. AFter a few weeks I cut back to 6 a day because I became C. My GI told me not to chew the tablets or my tongue would turn black. No problem, I broke them in 1/2 and swallowed with water. You don't have to chew them. I have not taken any other medication but changed my diet as recommended in Tex's book and reading the forums on here. I'm in remission for 5 years now. I haven't had to take the Pepto since then except 1 time when I thought it was tuna that I ate, but I figured out I took too much zinc and it caused D.
Marcia
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My mission in life is not merely to survive, but to thrive and to do so with some passion, some compassion, some humor and some style. - M. Angelou
KarenT
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Post by KarenT »

Marcia thank you for sharing your success story!! I am hopeful that the PB will help. My fingers are crossed....funny you mention just swallowing the chewable as I did that just five minutes ago! 😉
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tex
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Post by tex »

I'm told they now offer a tablet designed for swallowing (in addition to the gel caplet that's meant to be swallowed). Both of those should prevent black tongue.

Tex
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It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
KarenT
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Post by KarenT »

I'm all about preventing Black Tongue, Tex! :lol:
Karen
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