Decrease in joint pain concurrent with onset of CNBD
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Decrease in joint pain concurrent with onset of CNBD
Anyone experience a huge decrease in longstanding joint pain when their D first started (before dietary or medicinal treatment started)? From reading this forum and elsewhere, it seems rather anomalous, anomalous to the point of making MC an unlikely diagnosis. I'm looking for "culprits" that would both cause a dramatic reduction in longstanding joint pain and also cause a long ongoing bout of chronic non bloody diarrhea CNBD.
If you've been diagnosed, then it's not likely you don't have it. That doesn't mean you don't have something else going on.
Your post did bring up memories of the beginning that I had written off as related to a hospital stay (flu, virus, etc) I had muscle aches, especially in the morning. I don't know if they disappeared so much as they weren't as important when faced with WD.
Your post did bring up memories of the beginning that I had written off as related to a hospital stay (flu, virus, etc) I had muscle aches, especially in the morning. I don't know if they disappeared so much as they weren't as important when faced with WD.
I just read Townsend et al 2018 Frontine Gastroenterolgy, which cited Larsson et al 2014 BMC Research Notes. The stated publication timeline in Larsson leads me to wonder about the study's peer review processing.
Larsson et al found that of 78 CNBD patients sent for a colonoscopy, the final outcomes were:
14 (20%) macropathologies
16 (20%) micropathologies (MC)
16 (20%) further testing
16 (20%) resolved on their own
16 (20%) unknown
The 20% MC is somewhat high in light of recent prior studies. They had reported:
16% Fernandez-Banares et al 1999
10% Jaskiewicz et al 2006
10% Olesen et al 2004
13% Thijs et al 2005
19% da Silva et al 2006
Anyway, dramatic reduction in cronic pain contemporaneous with CNBD seems paradoxal. Larsson is disheartening on this however. Not directly, but their study looked widely at various factors (blood tests, stool test, interview, history). Only NSAID use and Celiac disease were risk factors for MC. In particular, inflammatory parameters from pre-colonoscopy blood work held no association with MC diagnosis.
Larsson et al found that of 78 CNBD patients sent for a colonoscopy, the final outcomes were:
14 (20%) macropathologies
16 (20%) micropathologies (MC)
16 (20%) further testing
16 (20%) resolved on their own
16 (20%) unknown
The 20% MC is somewhat high in light of recent prior studies. They had reported:
16% Fernandez-Banares et al 1999
10% Jaskiewicz et al 2006
10% Olesen et al 2004
13% Thijs et al 2005
19% da Silva et al 2006
Anyway, dramatic reduction in cronic pain contemporaneous with CNBD seems paradoxal. Larsson is disheartening on this however. Not directly, but their study looked widely at various factors (blood tests, stool test, interview, history). Only NSAID use and Celiac disease were risk factors for MC. In particular, inflammatory parameters from pre-colonoscopy blood work held no association with MC diagnosis.