I All, in a bit of a flare. I've had CC since January 2016. I've tried diet changes, budesonide, Zyrtec, and Pepto. Petpt has so far been the best, however my labs have recently indicated my kidney's aren't functioning as well and my Igg has dropped. Tried reducing Pepto to 1 pill a day and now have a flare...cramping and lose. Since I respond okay to Pepto I'm thinkingmy CC has been due to bad bacteria. I had a horrible case of the stomach bug in 2014 and 2015. I'm wondering if the bad bacteria never fully left my colon and has played a roll in the development of my CC.
I found this article from John Hopkins about MC and was curious about the treatment of using Metronidazole. You'll find it on the last past under Antibacterial Agents. Thoughts? Experiences? Am I wrong about bad bacteria causing CC?
https://www.hopkinsmedicine.org/gastroe ... olitis.pdf
Thanks Everyone! I really hate this disease.
Anyone tried Metronizdazole?
Moderators: Rosie, Stanz, Jean, CAMary, moremuscle, JFR, Dee, xet, Peggy, Matthew, Gabes-Apg, grannyh, Gloria, Mars, starfire, Polly, Joefnh
"Antibiotics, probiotics, Boswellia serrata"
"Antibiotics such as metronidazole or erythromycin have been used, but not in a controlled fashion. Probiotic treatment shows uncertain results and needs further evaluation [109]. Boswellia serrata extract has been tried in a placebo-controlled trial, showing a nonsignificant trend in favor of active treatment [110]."
The above quote comes from a dated review (but of the same vintage as the Hopkins paper in your link):
Recent advances in diagnosis and treatment of microscopic colitis
Tysk et al, Annals of Gastroenterology 2011; 24(4): 253–262.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959332
The review paper covers 8 different approaches to MC treatment:
antidiarrheals
budesonide
prednisolone
bismuth subsalicylate
aminosalicylates
antibiotics, probiotics, boswellia serrata
immunosuppression
surgery
"Antibiotics such as metronidazole or erythromycin have been used, but not in a controlled fashion. Probiotic treatment shows uncertain results and needs further evaluation [109]. Boswellia serrata extract has been tried in a placebo-controlled trial, showing a nonsignificant trend in favor of active treatment [110]."
The above quote comes from a dated review (but of the same vintage as the Hopkins paper in your link):
Recent advances in diagnosis and treatment of microscopic colitis
Tysk et al, Annals of Gastroenterology 2011; 24(4): 253–262.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959332
The review paper covers 8 different approaches to MC treatment:
antidiarrheals
budesonide
prednisolone
bismuth subsalicylate
aminosalicylates
antibiotics, probiotics, boswellia serrata
immunosuppression
surgery
44 patient study in 2011 to determine prevalence of MC in Egypt: "Some patients received 2-3 days course of antimicrobial drugs, including metronidazole, nifuroxazide, tetracycline, or diphenoxylate to treat diarrhea. There was partial response to therapy but without permanent remission."
Prevalence of Microscopic Colitis in Patients with Chronic Diarrhea in Egypt: A Single-center Study
Gado et al
Saudi Journal of Gastroenterology 17(6):383-6 · November 2011
https://www.researchgate.net/publicatio ... nter_Study
Prevalence of Microscopic Colitis in Patients with Chronic Diarrhea in Egypt: A Single-center Study
Gado et al
Saudi Journal of Gastroenterology 17(6):383-6 · November 2011
https://www.researchgate.net/publicatio ... nter_Study
On the upside, 2019 review paper discussed a number of treatments for refractory MC: "No controlled clinical trials evaluating antibiotic use exist; however, metronidazole and erythromycin have been used anecdotally with varying success.[1]"
Management of microscopic colitis: challenges and solutions.
Shor et al
Clin Exp Gastroenterol. 2019 Feb 27;12:111-120
Management of microscopic colitis: challenges and solutions.
Shor et al
Clin Exp Gastroenterol. 2019 Feb 27;12:111-120
A couple quotes from a review from 1996.
Shor et al (previous post) cite the following paper. It is likely their source for the "varying success" quote I placed in previous post.
"Various antibiotics and mepacrine hydrochloride seem to be helpful in collagenous colitis, and generally with very few side effects. Metronidazole and erythromycin were the most often prescribed drugs, and most patients (55% [24 of 44 patients] and 67%, respectively) responded well."
"(5) Antibiotics such as metronidazole, erythromycin, or penicillin G or mepacrine often relieve symptoms for some weeks, but seldom give a longlasting effect."
Collagenous colitis: a retrospective study of clinical presentation and treatment in 163 patients.
Bohr et al
Gut. 1996 Dec; 39(6): 846–851.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1383457
Shor et al (previous post) cite the following paper. It is likely their source for the "varying success" quote I placed in previous post.
"Various antibiotics and mepacrine hydrochloride seem to be helpful in collagenous colitis, and generally with very few side effects. Metronidazole and erythromycin were the most often prescribed drugs, and most patients (55% [24 of 44 patients] and 67%, respectively) responded well."
"(5) Antibiotics such as metronidazole, erythromycin, or penicillin G or mepacrine often relieve symptoms for some weeks, but seldom give a longlasting effect."
Collagenous colitis: a retrospective study of clinical presentation and treatment in 163 patients.
Bohr et al
Gut. 1996 Dec; 39(6): 846–851.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1383457
Here is an MCF thread from 2014 that talks about antibiotics, though it doesn't mention Metronidazole:
https://perskyfarms.com/phpBB2/viewtopic.php?t=19771
https://perskyfarms.com/phpBB2/viewtopic.php?t=19771