Celiac disease
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Celiac disease
I had a rough time for almost a year with watery diarrhea 10+ times a day and felt run-down and ill. I had a colonoscopy and upper GI test where I was biopsied for both MC and Celiac. The celiac test came back inconclusive but I did get diagnosed with CC. I have gene HLA-DQ2 and my tTG-Iga blood test was positive. I had been gluten-free in an attempt to feel better, so that explains the negative celiac biopsy I guess. My question is this...Can Microscopic Colitis make the tTG-Iga antibody test positive?
Re: Celiac disease
Yes, but if you have celiac disease, that's probably a moot point, because it's gluten sensitivity that triggers the tTG – Iga, and both celiac disease and microscopic colitis are associated with gluten sensitivity. See the link below for additional information:
https://www.enterolab.com/StaticPages/T ... spx#tissue
Your celiac test result was probably inconclusive because the diagnostic criteria for celiac disease are so poorly defined that they will only accurately diagnose about 5 to 10% of celiacs. And yes, your test was surely inconclusive if you had been avoiding gluten, because of that lack of sensitivity. By contrast, the EnteroLab stool test can accurately detect gluten sensitivity for at least two years after gluten is removed from the diet.
There are six possible Marsh scores, 1, 2, 3a, 3b, 3c, and 4. All of these classifications past 1 are unnecessary, because one could be used to diagnose the disease, since it's associated with inflammation of the tips of the villi. But for some strange reason, the medical community insists that at least a Marsh 3 score is necessary to confirm a celiac diagnosis. By the time a patient qualifies for a Marsh three score, the disease has may have been developing for several years. Why postpone a diagnosis of the disease for so long? That's poor patient care.
Anyway, to get to the point, MC typically causes a Marsh 1 score. MC patients occasionally reach a Marsh 2 condition, but the point is, they rarely reach stages 3 or 4. Technically, this is non-celiac gluten sensitivity. But if we're reacting to gluten, why would be give a hoot what their technical classification might be. We're reacting, so we're gluten-sensitive. Period.
I hope I haven't just muddied the waters.
Tex
https://www.enterolab.com/StaticPages/T ... spx#tissue
Your celiac test result was probably inconclusive because the diagnostic criteria for celiac disease are so poorly defined that they will only accurately diagnose about 5 to 10% of celiacs. And yes, your test was surely inconclusive if you had been avoiding gluten, because of that lack of sensitivity. By contrast, the EnteroLab stool test can accurately detect gluten sensitivity for at least two years after gluten is removed from the diet.
There are six possible Marsh scores, 1, 2, 3a, 3b, 3c, and 4. All of these classifications past 1 are unnecessary, because one could be used to diagnose the disease, since it's associated with inflammation of the tips of the villi. But for some strange reason, the medical community insists that at least a Marsh 3 score is necessary to confirm a celiac diagnosis. By the time a patient qualifies for a Marsh three score, the disease has may have been developing for several years. Why postpone a diagnosis of the disease for so long? That's poor patient care.
Anyway, to get to the point, MC typically causes a Marsh 1 score. MC patients occasionally reach a Marsh 2 condition, but the point is, they rarely reach stages 3 or 4. Technically, this is non-celiac gluten sensitivity. But if we're reacting to gluten, why would be give a hoot what their technical classification might be. We're reacting, so we're gluten-sensitive. Period.
I hope I haven't just muddied the waters.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Re: Celiac disease
Thank you Tex. Gluten makes me very nauseated and sometimes vomit, so I know that gluten is gone forever. Not a big deal. While gluten-free, it didn't stop the watery diarrhea many times a day. I was gluten-free for approximately 2 months, so I thought something else was wrong and suspected MC. I am reading your book now and am learning a lot. I'm on day 7 of Budesonide and have stopped having accidents in the night and only going once or twice a during the day. Pressing forward to eliminate the root cause of the inflammation.