Has anyone here been tested for Candidia yeast infection? Supposedly this yeast has a protein signature similar to gluten. I'll have to look up more info.
Here's more info:
http://www.denvernaturopathic.com/news/celiac.html
Celiac Disease, Gluten Ataxia and Candidiasis
Moderators: Rosie, Stanz, Jean, CAMary, moremuscle, JFR, Dee, xet, Peggy, Matthew, Gabes-Apg, grannyh, Gloria, Mars, starfire, Polly, Joefnh
Perhaps this turned out to be a dead end, but this article is rather interesting.
http://www.ncbi.nlm.nih.gov/entrez/quer ... med_docsum
http://www.ncbi.nlm.nih.gov/entrez/quer ... med_docsum
Lancet. 2003 Jun 21;361(9375):2152-4.
Is Candida albicans a trigger in the onset of coeliac disease?
Nieuwenhuizen WF, Pieters RH, Knippels LM, Jansen MC, Koppelman SJ.
Netherlands Organisation for Applied Scientific Research (TNO) Nutrition and Food Research, PO Box 360, 3700 AJ, Zeist, Netherlands. nieuwenhuizen@voeding.tno.nl
Coeliac disease is a T-cell-mediated autoimmune disease of the small intestine that is induced by ingestion of gluten proteins from wheat, barley, or rye. We postulate that Candida albicans is a trigger in the onset of coeliac disease. The virulence factor of C albicans-hyphal wall protein 1 (HWP1)-contains aminoacid sequences that are identical or highly homologous to known coeliac disease-related alpha-gliadin and gamma-gliadin T-cell epitopes. HWP1 is a transglutaminase substrate, and is used by C albicans to adhere to the intestinal epithelium. Furthermore, tissue transglutaminase and endomysium components could become covalently linked to the yeast. Subsequently, C albicans might function as an adjuvant that stimulates antibody formation against HWP1 and gluten, and formation of autoreactive antibodies against tissue transglutaminase and endomysium.
And guess what else is protective against Candida albicans?
http://www.ncbi.nlm.nih.gov/entrez/quer ... s=10826722
Seems that folks who take antibiotics would have those good bacteria killed, folks who didn't breast feed might not have those good bacteria and I'm sure there are other mechanisms. And those folks wouldn't be protected and thus might get an infection and end up with gluten sensitivity due to an immune response.
http://www.ncbi.nlm.nih.gov/entrez/quer ... s=10826722
Seems that folks who take antibiotics would have those good bacteria killed, folks who didn't breast feed might not have those good bacteria and I'm sure there are other mechanisms. And those folks wouldn't be protected and thus might get an infection and end up with gluten sensitivity due to an immune response.
Mike,
I didn't have time to read any of your links, (I've gotta get back to work), but several members here have been treated for Candida overgrowth at one time or another. Probably Candida's worst offense, as far as MCers are concerned, is the fact that it is a contributor to Leaky Gut Syndrome, since it's roots penetrate the intestinal wall.
Tex
P S As poor as the diagnostic rate for celiac disease is in some of the developed countries, (such as the US), it's not likely that it would be diagnosed adequately enough in undeveloped countries to even draw any reasonably accurate conclusions.
I didn't have time to read any of your links, (I've gotta get back to work), but several members here have been treated for Candida overgrowth at one time or another. Probably Candida's worst offense, as far as MCers are concerned, is the fact that it is a contributor to Leaky Gut Syndrome, since it's roots penetrate the intestinal wall.
Tex
P S As poor as the diagnostic rate for celiac disease is in some of the developed countries, (such as the US), it's not likely that it would be diagnosed adequately enough in undeveloped countries to even draw any reasonably accurate conclusions.
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Does anyone here have access to this article? I'd like to read the significance of antigliadin antibodies.
http://www.ncbi.nlm.nih.gov/entrez/quer ... med_docsum
http://www.ncbi.nlm.nih.gov/entrez/quer ... med_docsum
Hi MIke,
Interesting articles.
Where was the gluten ataxia mentioned in conjunction with the Candida?
So was that one study saying that the acidophilus worked and the casein one didn't, or did I misread something.
While you've brought this up, I have wondered for a while if perhaps my long terms symptoms weren't really from undiagnosed classical celiac disease and general gs, and then, it just so happened that I got a bad overgrowth from a post-surgical antibiotic a couple of months before getting the colonoscopy, which picked up the M.C. I will always wonder if I'd had the colonoscopy back before the overgrowth, if the biopsy would've shown anything since it wasn't of the small bowel where the long-term problems were probably coming from.
The GI informed me that I had thrush on the pre-colonoscopy visit, and gave me treatment for it, and we assumed it resulted from the antibiotic leading to the overgrowth, etc.
A couple of months before, the week after the surgery, I'd had to be readmitted with a cardiac arrrythmia, and at the ER, they discovered that I had a temp of 102. I'd been here with Mom taking those antibiotics the entire week after coming home from surgery, and it was exactly a week when I landed in telemetry. I had a really watery, sudden outburst of diarrhea before discharge after being put back on the antibiotic to finish it because the ER doc wanted to get rid of whatever the infection was, just in case it was something horrific.
Actually, the arrhythmia got better with just Tylenol, but I still had to be observed in the hospital the whole weekend.
On call doc did a C-diff test which was negative, and probably they gave me something like diflucan, but I really don't remember. I do know that as soon as I got the huge dose of live culture yogurt that I had requested, I noticed a remarkable change in the way my tummy felt. (This was before I knew anything about my casein reactions, but I know it was the probiotic action that really helped me at that time.)
After that, my symptoms pretty much went back to the way they'd been before. Stools went back to their old yucky selves just like they'd been before.
Even though I should've had the routine colonoscopy five years before due to age (I didn't see a GI before, if you can believe that!! Denial, bigtime!), what actually got me in to do it was that I had a thrombosed type hemorrhoid right after these two hospitalizations, one for the thyroidectomy and a week later for the arrhythmia.
Ya have to make sure there's nothing else going on with a mess like that, so that's how I got the diagnosis of M.C. from the pathologist. Could it have just been the timing of the colonoscopy, since it was so soon after the probably overgrowth problem?
At any rate, if I'd have been diagnosed with celiac disease, I sort of doubt that I'd know half as much about what's good for me to eat, and what's not, so I guess, in a way, it's a blessing that this was diagnosed instead.
Yours, Luce
Interesting articles.
Where was the gluten ataxia mentioned in conjunction with the Candida?
So was that one study saying that the acidophilus worked and the casein one didn't, or did I misread something.
While you've brought this up, I have wondered for a while if perhaps my long terms symptoms weren't really from undiagnosed classical celiac disease and general gs, and then, it just so happened that I got a bad overgrowth from a post-surgical antibiotic a couple of months before getting the colonoscopy, which picked up the M.C. I will always wonder if I'd had the colonoscopy back before the overgrowth, if the biopsy would've shown anything since it wasn't of the small bowel where the long-term problems were probably coming from.
The GI informed me that I had thrush on the pre-colonoscopy visit, and gave me treatment for it, and we assumed it resulted from the antibiotic leading to the overgrowth, etc.
A couple of months before, the week after the surgery, I'd had to be readmitted with a cardiac arrrythmia, and at the ER, they discovered that I had a temp of 102. I'd been here with Mom taking those antibiotics the entire week after coming home from surgery, and it was exactly a week when I landed in telemetry. I had a really watery, sudden outburst of diarrhea before discharge after being put back on the antibiotic to finish it because the ER doc wanted to get rid of whatever the infection was, just in case it was something horrific.
Actually, the arrhythmia got better with just Tylenol, but I still had to be observed in the hospital the whole weekend.
On call doc did a C-diff test which was negative, and probably they gave me something like diflucan, but I really don't remember. I do know that as soon as I got the huge dose of live culture yogurt that I had requested, I noticed a remarkable change in the way my tummy felt. (This was before I knew anything about my casein reactions, but I know it was the probiotic action that really helped me at that time.)
After that, my symptoms pretty much went back to the way they'd been before. Stools went back to their old yucky selves just like they'd been before.
Even though I should've had the routine colonoscopy five years before due to age (I didn't see a GI before, if you can believe that!! Denial, bigtime!), what actually got me in to do it was that I had a thrombosed type hemorrhoid right after these two hospitalizations, one for the thyroidectomy and a week later for the arrhythmia.
Ya have to make sure there's nothing else going on with a mess like that, so that's how I got the diagnosis of M.C. from the pathologist. Could it have just been the timing of the colonoscopy, since it was so soon after the probably overgrowth problem?
At any rate, if I'd have been diagnosed with celiac disease, I sort of doubt that I'd know half as much about what's good for me to eat, and what's not, so I guess, in a way, it's a blessing that this was diagnosed instead.
Yours, Luce
Hi Luce,Lucy wrote:Hi MIke,
Interesting articles.
Where was the gluten ataxia mentioned in conjunction with the Candida?
So was that one study saying that the acidophilus worked and the casein one didn't, or did I misread something.
While you've brought this up, I have wondered for a while if perhaps my long terms symptoms weren't really from undiagnosed classical celiac disease and general gs, and then, it just so happened that I got a bad overgrowth from a post-surgical antibiotic a couple of months before getting the colonoscopy, which picked up the M.C. I will always wonder if I'd had the colonoscopy back before the overgrowth, if the biopsy would've shown anything since it wasn't of the small bowel where the long-term problems were probably coming from.
The GI informed me that I had thrush on the pre-colonoscopy visit, and gave me treatment for it, and we assumed it resulted from the antibiotic leading to the overgrowth, etc.
A couple of months before, the week after the surgery, I'd had to be readmitted with a cardiac arrrythmia, and at the ER, they discovered that I had a temp of 102. I'd been here with Mom taking those antibiotics the entire week after coming home from surgery, and it was exactly a week when I landed in telemetry. I had a really watery, sudden outburst of diarrhea before discharge after being put back on the antibiotic to finish it because the ER doc wanted to get rid of whatever the infection was, just in case it was something horrific.
Actually, the arrhythmia got better with just Tylenol, but I still had to be observed in the hospital the whole weekend.
On call doc did a C-diff test which was negative, and probably they gave me something like diflucan, but I really don't remember. I do know that as soon as I got the huge dose of live culture yogurt that I had requested, I noticed a remarkable change in the way my tummy felt. (This was before I knew anything about my casein reactions, but I know it was the probiotic action that really helped me at that time.)
After that, my symptoms pretty much went back to the way they'd been before. Stools went back to their old yucky selves just like they'd been before.
Even though I should've had the routine colonoscopy five years before due to age (I didn't see a GI before, if you can believe that!! Denial, bigtime!), what actually got me in to do it was that I had a thrombosed type hemorrhoid right after these two hospitalizations, one for the thyroidectomy and a week later for the arrhythmia.
Ya have to make sure there's nothing else going on with a mess like that, so that's how I got the diagnosis of M.C. from the pathologist. Could it have just been the timing of the colonoscopy, since it was so soon after the probably overgrowth problem?
At any rate, if I'd have been diagnosed with celiac disease, I sort of doubt that I'd know half as much about what's good for me to eat, and what's not, so I guess, in a way, it's a blessing that this was diagnosed instead.
Yours, Luce
I didn't pay much attention to the ataxia, sorry. I was more interested in how part of the proteins for both candida and gliadin looked the same.
And yes, it appears that the casein bacteria didn't do anything whereas the acidophilus did have some limited protection.
It is rather interesting the coincidence of all of this and reading others reports with candida. I'm really going to have to research more here. I mentioned elsewhere that this may be a dead end as there doesn't appear to be any studies with regards to gluten and this fungi past the one I posted.
I've often wondered if the inflamation we see isn't just a symptom of something else or a result of something else. Stuff like this really makes me wonder.
In fact there was a bit of info I read how some think that ulcerative colitis has to do with hydrogen peroxide. Here's more on the theory:
http://en.wikipedia.org/wiki/Radical_In ... ve_Colitis
And if that goes away as it's marked for deletion here's the original document:
http://www.wjgnet.com/1007-9327/11/2371.pdf
Thanks,
Mike
Well, well, what have we here. Another pathogen that looks like gliadin.
http://www.ncbi.nlm.nih.gov/entrez/quer ... ds=8324388
http://www.ncbi.nlm.nih.gov/entrez/quer ... med_docsum
Seems others have a similar idea about antigens:
http://www.ncbi.nlm.nih.gov/entrez/quer ... med_DocSum
Wonder what else out there looks like gliadin?
Oh and I found out about this gliadin like virus here:
http://www.amc.edu/amr/archives/200108/case02.html
Note the similarity with some folks here. Yet again, hmmmmmm...
Mike
http://www.ncbi.nlm.nih.gov/entrez/quer ... ds=8324388
http://www.ncbi.nlm.nih.gov/entrez/quer ... med_docsum
Seems others have a similar idea about antigens:
http://www.ncbi.nlm.nih.gov/entrez/quer ... med_DocSum
Wonder what else out there looks like gliadin?
Oh and I found out about this gliadin like virus here:
http://www.amc.edu/amr/archives/200108/case02.html
Note the similarity with some folks here. Yet again, hmmmmmm...
Mike
And take a look at this:
http://www.ncbi.nlm.nih.gov/entrez/quer ... ds=1696236
http://www.ncbi.nlm.nih.gov/entrez/quer ... ds=1696236
This finding was rather intresting:
http://www.ncbi.nlm.nih.gov/entrez/quer ... med_DocSum
Here we have a case of antigliadin yet no celiac.
http://www.ncbi.nlm.nih.gov/entrez/quer ... med_DocSum
Here we have a case of antigliadin yet no celiac.
Mike,
Very interesting articles, especially the third one in your third from last post, concerning the comment about suspecting the possible involvement of a virus or bacteria in the development of CD. That article was written over 9 years ago. One would think that by now, someone would have carried the search a little further, to either verify or disprove the connection.
Tex
Very interesting articles, especially the third one in your third from last post, concerning the comment about suspecting the possible involvement of a virus or bacteria in the development of CD. That article was written over 9 years ago. One would think that by now, someone would have carried the search a little further, to either verify or disprove the connection.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Hi Tex,tex wrote:Mike,
Very interesting articles, especially the third one in your third from last post, concerning the comment about suspecting the possible involvement of a virus or bacteria in the development of CD. That article was written over 9 years ago. One would think that by now, someone would have carried the search a little further, to either verify or disprove the connection.
Tex
Right, the thing of it is that it doesn't even need to be the cause. I believe that the pathogens are the cause of having the HLA-DQ2 and 8, but not nessesarily the reason that one gets Celiac. I believe that sometime in the past a virus, bacteria, fungi was passing from person to person infecting them and killing them off, the folks with the genes survived (were naturally selected) lived on and passed their genes.
One problem with a bunch of the studies were that they tested for past or current infection with said pathogens. Well, the problem is that the virus could have been killed off thus none found, not even aquired immunity as the innate killed it off.
Or the other problem is that they tested for pathogen A, but there could have been pathogen B with the same signature that caused the problem. Looking for A they never looked for B.
I'm reading some interesting stuff on ttg, the biological glues, and comming up with some interesting ideas. Even ones that seem to fit with IBDs including Lymphocytic Colitis or CC as well.
It's starting to make sense to me now why one might have antibodies for gliadin or even ttg and other body tissues and still not have Celiac.
Gotta spend a bit more time thinking it through and reading more before I say much else. I started a blog over at glutenfreeforum.com to help gather my ideas and ask for comments. I'm finding all this a bit too interesting at times. Taking time were I probably shouldn't let it. LOL
Thanks,
Mike