Enterolab Results for HLA-DQ Gene Molecular Analysis

[tex]

Hi All,

As Alice suggested, if everyone who has had a gene test of this type done, will post their results in this thread, we can compare results, and save the information for future reference.

I have compiled the results received so far, and listed them below:

Alex (alexandraCA)
HLA-DQB1 Molecular analysis, Allele 1 0501
HLA-DQB1 Molecular analysis, Allele 2 0604
Serologic equivalent: HLA-DQ 1,1 (Subtype 5,6). Both of these genes predispose to gluten sensitivity. Note that this is a double DQ1 combination, usually connected with increased sensitivity, and more food intolerances.

Alice
HLA-DQB1 Molecular analysis, Allele 1 0301
HLA-DQB1 Molecular analysis, Allele 2 0501
Serologic equivalent: HLA-DQ 3,1 (Subtype 7,5). Predisposes to MC and gluten sensitivity, but not celiac.

Andrew (thedell19)
HLA-DQB1 Molecular analysis, Allele 1 0201
HLA-DQB1 Molecular analysis, Allele 2 0201
Serologic equivalent: HLA-DQ 2,2 (Subtype 2,2). These are two copies of the main celiac gene, one from each parent. Note that this is a double DQ2 combination, usually connected with increased sensitivity, and more food intolerances, plus an increased risk of developing celiac disease.

Ant
HLA-DQB1 Molecular analysis, Allele 1 0201
HLA-DQB1 Molecular analysis, Allele 2 0302
Serologic equivalent: HLA-DQ 2,3 (Subtype 2,8). These are the two main genes that predispose to celiac sprue.

bea
HLA-DQB1 Molecular analysis, Allele 1 0301
HLA-DQB1 Molecular analysis, Allele 2 0302
Serologic equivalent: HLA-DQ 3,3 (Subtype 7,8). The first one is connected with a non-celiac gluten sensitivity, while the second one is the second most common celiac gene. Note that this is a double DQ3 combination, usually connected with increased sensitivity, and more food intolerances.

bobh
HLA-DQB1 Molecular analysis, Allele 1 0201
HLA-DQB1 Molecular analysis, Allele 2 0201
Serologic equivalent: HLA-DQ 2,2 (Subtype 2,2). These are two copies of the main celiac gene, one from each parent. Note that this is a double DQ2 combination, usually connected with increased sensitivity, and more food intolerances, plus an increased risk of developing celiac disease.

CAMary
HLA-DQB1 Molecular analysis, Allele 1 0501
Serologic equivalent: HLA-DQ 1 (Subtype 5).

Camryn
HLA-DQB1 Molecular analysis, Allele 1 0501
HLA-DQB1 Molecular analysis, Allele 2 0602
Serologic equivalent: HLA-DQ 1,1 (Subtype 5,6). Both of these genes predispose to gluten sensitivity. Note that this is a double DQ1 combination, usually connected with increased sensitivity, and more food intolerances.

Carrie
DQ-2. My tests were done at Prometheus, not Enterolab (Prometheus tests only for DQ-2 and DQ-8).

Celia
HLA-DQB1 Molecular analysis, Allele 1 0501
HLA-DQB1 Molecular analysis, Allele 2 0502
Serologic equivalent: HLA-DQ 1,1 (Subtype 5,5). Predisposes to MC and gluten sensitivity, but not celiac. Note that this is a double DQ1 combination, usually connected with increased sensitivity, and more food intolerances.

Courtney
HLA-DQB1 Molecular analysis, Allele 1 0501
HLA-DQB1 Molecular analysis, Allele 2 0201
Serologic equivalent: HLA-DQ 1,2 (Subtype 5,2). The first one is connected with a non-celiac gluten sensitivity, while the second one is the most common celiac gene.

Cristi
HLA-DQB1 molecular analysis allele 1 0301
HLA-DQB1 molecular analysis allele 2 0501
Serologic equivalent HLA-DQ 3, 1 ( subtype 7, 5 ). Predisposes to MC and gluten sensitivity, but not celiac.

Dan (Delta)
HLA-DQB1 Molecular analysis, Allele 1 0302
HLA-DQB1 Molecular analysis, Allele 2 0602
Serologic equivalent: HLA-DQ 3,1 (Subtype 8,6). The first one listed is the second most common celiac gene, often referred to as HLA-DQ8, while the second is a non-celiac gene that predisposes to gluten sensitivity.

Dee
HLA-DQB1 Molecular analysis, Allele 1 0301
HLA-DQB1 Molecular analysis, Allele 2 0602
Serologic equivalent: HLA-DQ 3,1 (Subtype 7,6). Predisposes to gluten sensitivity and MC, but not celiac.

Faith
HLA-DQB1 Molecular analysis, Allele 1 0501
HLA-DQB1 Molecular analysis, Allele 2 0502
Serologic equivalent: HLA-DQ 1,1 (Subtype 5,5). Predisposes to MC and gluten sensitivity, but not celiac. Note that this is a double DQ1 combination, usually connected with increased sensitivity, and more food intolerances.

Ginny
HLA-DQB1 Molecular analysis, Allele 1: 0201
HLA-DQB1 Molecular analysis, Allele 2: 0602
Serologic equivalent: HLA-DQ 2,1 (Subtype 2,6). The first one listed is the most common celiac gene, often referred to as HLA-DQ2, while the second is a non-celiac gene that predisposes to gluten sensitivity.

Gloria
HLA-DQB1 Molecular analysis, Allele 1 0501
HLA-DQB1 Molecular analysis, Allele 2 06xx
Serologic equivalent: HLA-DQ 1,1 (Subtype 5,6). This appears to match Polly's results. Note that this is a double DQ1 combination, usually connected with increased sensitivity, and more food intolerances.

Harma
HLA-DQB1 Molecular analysis, Allele 1: 0302
HLA-DQB1 Molecular analysis, Allele 2: 0301
Serologic equivalent: HLA-DQ 3,3 (Subtype 8,7). The first one listed is the second most common celiac gene, often referred to as HLA-DQ8, while the second is a non-celiac gene that predisposes to gluten sensitivity. Note that this is a double DQ3 combination, usually connected with increased sensitivity, and more food intolerances.

Hotrod (RUBYREDDOG)
HLA-DQB1 Molecular analysis, Allele 1 0301
HLA-DQB1 Molecular analysis, Allele 2 0503
Serologic equivalent: HLA-DQ 3,1 (Subtype 7,5). Predisposes to MC and gluten sensitivity, but not celiac.

Joan (JLH)
HLA-DQB1 Molecular analysis, Allele 1 0301
HLA-DQB1 Molecular analysis, Allele 2 0603
Serologic equivalent: HLA-DQ 3,1 (Subtype 7,6). Predisposes to gluten sensitivity and MC, but not celiac.

JoAnn
HLA-DQB1 Molecular analysis, Allele 1 0202
HLA-DQB1 Molecular analysis, Allele 2 0602
Serologic equivalent: HLA-DQ 2,1 (Subtype 2,6). Predisposes to MC and gluten sensitivity, but not celiac.

Kathy (kscolorado)
HLA-DQB1 Molecular analysis, Allele 1 0201
HLA-DQB1 Molecular analysis, Allele 2 0302
Serologic equivalent: HLA-DQ 2,3 (Subtype 2,8). These are the two main genes that predispose to celiac sprue.

Kimberley (kimpat)
HLA-DQB1 Molecular analysis, Allele 1 0502
HLA-DQB1 Molecular analysis, Allele 2 0602
Serologic equivalent: HLA-DQ 1,1 (Subtype 5,6). This also appears to match Polly's results. Note that this is a double DQ1 combination, usually connected with increased sensitivity, and more food intolerances.

Lucy
HLA-DQB1 Molecular analysis, Allele 1 0201
HLA-DQB1 Molecular analysis, Allele 2 0602
Serologic equivalent: HLA-DQ 2,1 (Subtype 2,6). The first one is the most common celiac gene.

Mary Beth (mbeezie)
HLA-DQB1 Molecular analysis, Allele 1 0501
HLA-DQB1 Molecular analysis, Allele 2 0604
Serologic equivalent: HLA-DQ 1,1 (Subtype 5,6). Both of these genes predispose to gluten sensitivity. Note that this is a double DQ1 combination, usually connected with increased sensitivity, and more food intolerances.

Mary (maude)
HLA-DQB1 Molecular analysis, Allele 1 0202
HLA-DQB1 Molecular analysis, Allele 2 0604
Serologic equivalent: HLA-DQ 2,1 (Subtype 2,6)

Matthew
HLA-DQB1 Molecular analysis, Allele 1 0201
HLA-DQB1 Molecular analysis, Allele 2 0302
Serologic equivalent: HLA-DQ 2,3 (Subtype 2,8). These are the two main genes that predispose to celiac sprue.

Mike (mle_ii)
HLA-DQB1 Molecular analysis, Allele 1 0201
HLA-DQB1 Molecular analysis, Allele 2 0301
Serologic equivalent: HLA-DQ 2,3 (Subtype 2,7). The first one is the most common celiac gene.

Pat
HLA-DQB1 Molecular analysis, Allele 1 0201
HLA-DQB1 Molecular analysis, Allele 2 0301
Serologic equivalent: HLA-DQ 2,3 (Subtype 2,7). The first one is the most common celiac gene, while the second is a non-celiac gene that predisposes to gluten sensitivity.

Polly
HLA-DQB1 Molecular analysis, Allele 1 0501
HLA-DQB1 Molecular analysis, Allele 2 0602
Serologic equivalent: HLA-DQ 1,1 (Subtype 5,6). Both of these genes predispose to gluten sensitivity. I see that I share a gene with Wayne and Alice (*0501) and one with Dee, too (*0602). I wonder if it would be possible to eventually determine other food intolerances based upon these specific gene patterns? Wouldn''t that be interesting (and helpful)? Note that this is a double DQ1 combination, usually connected with increased sensitivity, and more food intolerances.

Rick (crranch)
HLA-DQB1 Molecular analysis, Allele 1 0603
HLA-DQB1 Molecular analysis, Allele 2 0604
Serologic equivalent: HLA-DQ 1,1 (subtype 6,6). Predisposes to MC and gluten sensitivity, but not celiac. Note that this is a double DQ1 combination, usually connected with increased sensitivity, and more food intolerances.

Shirley (starfire)
HLA-DQB1 Molecular analysis, Allele 1 0202
HLA-DQB1 Molecular analysis, Allele 2 0301
Serologic Equivalent: HLA-DQ 2,3 (Subtype 2,7). Predisposes to MC and gluten sensitivy, but not celiac.

Shonda (manonash)
HLA-DQB1 Molecular analysis, Allele 1 0202
HLA-DQB1 Molecular analysis, Allele 2 0602
Serologic equivalent: HLA-DQ 2,1 (Subtype 2,6). Predisposes to MC and gluten sensitivity, but not celiac.

Stanz
HLA-DQB1 Molecular analysis, Allele 1: 0501
HLA-DQB1 Molecular analysis, Allele 2: 0603
Serologic equivalent: HLA-DQ 1,1 (Subtype 5,6). Both of these genes predispose to gluten sensitivity, but not celiac.

SueM
HLA-DQB1 Molecular analysis, Allele 1 0201
HLA-DQB1 Molecular analysis, Allele 2 0503
Serologic equivalent: HLA-DQ 2,1 (Subtype 2,5). The first one is the most common celiac gene.

sunny
HLA-DQB1 Molecular analysis, Allele 1 0302
HLA-DQB1 Molecular analysis, Allele 2 0602
Serologic equivalent: HLA-DQ 3,1 (Subtype 8,6). The first one listed is the second most common celiac gene, often referred to as HLA-DQ8, while the second is a non-celiac gene that predisposes to gluten sensitivity.

Tessa
HLA-DQB1 Molecular analysis, Allele 1 0201
HLA-DQB1 Molecular analysis, Allele 2 0503
Serologic equivalent: HLA-DQ 2,1 (Subtype 2,5). The first one predisposes to celiac sprue, while the second one is connected with a non-celiac gluten sensitivity.

Trace
HLA-DQB1 Molecular analysis, Allele 1 0201
HLA-DQB1 Molecular analysis, Allele 2 0302
Serologic equivalent: HLA-DQ 2,3 (subtype 2,8). These are both celiac genes.

Wayne (tex)
HLA-DQB1 Molecular analysis, Allele 1 0201
HLA-DQB1 Molecular analysis, Allele 2 0501
Serologic equivalent: HLA-DQ 2,1 (Subtype 2,5). The first one predisposes to celiac sprue, while the second one is connected with a non-celiac gluten sensitivity.

Wendy (piemom)
HLA-DQB1 Molecular analysis, Allele 1 0201
HLA-DQB1 Molecular analysis, Allele 2 0302
Serologic equivalent: HLA-DQ 2,3 (subtype 2,8). These are both celiac genes.

Thanks,
Tex (Wayne)

[SueM]

Molecular analysis: HLA-DQB1*0201, 0503
Serologic equivalent: HLA-DQ2,1 (Subtype 2,6)

HLA gene analysis reveals the main gene that predisposes to gluten sensitivity and celiac sprue (HLA-DQ2). This genotype also can predispose to microscoic colitis and other autoimmune syndromes.

Testing was done May 2003.
SueM

[Lucy]

HLA DQB1 0201 and 0602

Serol. Eq. to DQ2 and DQ1 (subtypes 2,6)

Main gene for celiac disease and 0602 predisposes to M.C., both to gluten sensitivity, I think.

Yours, Luce

[Alice]

Hmmm, I see that three of you have 0602. Wonder what that means, if anything? Lucy, Polly and Dee. And 0201: Lucy, Tex, Matthew, Sue.

Alice

[tex]

Hi Alice,

According to the definitions sent from the lab, with the test results,The 0602 molecular type indicates a predisposition to gluten sensitivity, and the 0201 molecular type indicates a susceptibility to celiac sprue.

Tex

[Lucy]

Alice,

Apparently, it means I'm in trouble!!!
Thank you for pointing this out. Maybe I won't feel so bad when the others with different genotypes post theirs. Ha!

Yours, Luce

[CAMary]

Well, I only have one- HLA-DQ1 involving DQB1 0501 subtype...

Perhaps this explains why I am not a multiple??

Mary

[tex]

Hmmmmmmmmmmmm. That matches one that is shared by Alice, Polly, and myself. It's interesting that you are so gluten sensitive, without the 201 molecular type. Obviously, that means that the celiacs don't have the market cornered on gluten sensitivity.

Tex

[Lucy]

Mary,

Sure do hope that the study coming out will pinpoint which foods go with which genotypes. For some reason, I just feel that it will as he's been collecting so much data for so long. Also, I heard that Dr. Fine believes that the "allergens" we have depend on which genes we have, so that makes me suspect that as well.

It's beginning to appear that these types of "allergies" are more predictable than the types that the allergists test for, isn't it. At least we know that it's a "for life" thing. Ya never know about the true allergy ones.

I think that I can safely call myself a celiac as the stool tests showed small bowel damage by the amount of fecal fat and the presence of anti-tTg in my stool. Whether or not a blood test or small bowel bx would've shown it back then is inconsequential to me as I'm following the only treatment for celiac disease by being strict with this gf, etc. diet.

Hope we get more results posted here. Maybe we can see if we can anticipate (guess at) what Dr. Fine's results will show in terms of the genetics?

Yours, Luce

[mle_ii]

Mine are HLA-DQB1*0201, 0301

[mle_ii]

Here's some info if you need to translate your lab results:

Interpretation Of HLA-DQ Testing by Molecular Analysis and Conversion to "Serologic Equivalent": Today HLA-DQ gene testing is done by analyzing DNA using molecular techniques. In the past, the methods were done by analyzing blood cells for the antigens produced by the genes, and these past methods were responsible for the most commonly known nomenclature for HLA-DQ genes even today (using integers such as "DQ2"). These are called "serologic equivalents" to the specifically analyzed gene material. The serologic equivalents are as follows:

* If the first two numbers of the molecular type are 05, the serologic equivalent is DQ1 subtype DQ5
* If the first two numbers of the molecular type are 06, the serologic equivalent is DQ1 subtype DQ6
* If the molecular type is 0201, the serologic equivalent is DQ2
* If the molecular type is 0301, the serologic equivalent is DQ3 subtype DQ7
* If the molecular type is 0302, the serologic equivalent is DQ3 subtype DQ8
* If the molecular type is 0303, the serologic equivalent is DQ3 subtype DQ9
* If the first two numbers of the molecular type are 03 but it is not 0301, 0302, or 0303, the serologic equivalent is DQ3
* If the first two numbers of the molecular type are 04, the serologic equivalent is DQ4

The gluten sensitive, celiac genes are HLA-DQB1*0201 and HLA-DQB1*0302 (HLA-DQ2 and HLA-DQ8, respectively).

The other gluten sensitive genes are any molecular type involving another HLA-DQB1*03 number (i.e., HLA-DQ3), or any HLA-DQB1*05 number, or any HLA-DQB1*06 number (i.e., HLA-DQ1)

[mle_ii]

My own----HLA-DB1*0201, 0501. The first one predisposes to celiac sprue, while the second one is connected with MC. They both indicate a predisposition to gluten sensitivity, of course.

Thanks,
Wayne

Hi Wayne, where did you read about 501 being associated with MC?

Thanks
Mike

[tex]

Mike,

Beats the heck out of me. It's been over two years since I had my tests and studied that stuff. Maybe I just assumed that it was, based on the fact that it indicates non-celiac gluten sensitivity, and most MCers are gluten sensitive.

If I recall correctly, the only subtype that Dr. Fine actually demonstrated to be directly connected with MC is DQ1,3.

Tex

[mle_ii]

Ah, here's the study:
http://www.ncbi.nlm.nih.gov/entrez/quer ... med_DocSum

So this means the following are related to MC. DQ2, DQ7, DQ8, DQ9

I decided to change the data above to make it a bit more readable so that a pattern can be seen. What's strange is that there are a few folks here that have differenet genes not YET associated with MC. Also, Matthew and I are the only 2 with both genes being associated with MC.

Tex------------ DQ2, DQ5 C MC
Alice---------- DQ7, DQ5 HGS MC
Dee------------ DQ7, DQ6 HGS MC
Polly---------- DQ5, DQ6
Carrie--------- DQ2 C MC
Matthew-------- DQ2, DQ7 C HGS MC
Celia---------- DQ5, DQ5
Terps---------- DQ2, DQ2 C MC
Cristi--------- DQ7, DQ5 HGS MC
Mike----------- DQ2, DQ7 C HGS MC
Sue------------ DQ2, DQ5 C MC
Lucy----------- DQ2, DQ6 C MC
CAMary--------- DQ5

DQ2 7 Celiac and MC
DQ5 7
DQ6 3
DQ7 5 High gluten sensitivity *1* and MC

*1* Understanding the Genetics of Gluten Sensitivity by Dr. Scot Lewey
http://www.celiac.com/st_prod.html?p_prodid=1359

[Lucy]

Hi Mike,

Mine is actually, HLA DQ 2 and DQ 1, for the record. The subtype of DQ 1 does not involve the part of the gene that is involved with M.C. or gs, and thus, practically speaking, we need not concern ourselves with.

My sister is also DQ2, DQ1 (a different subtype than mine) and has the exact same foods she is immunologically sensitive to as I do.
Thanks, Luce