Polls relevant to Microscopic Colitis, and related issues, can be posted here, to allow for the collection of data that might help to shed some light on this disease, and it's treatment options.
Mine is actually, HLA DQ 2 and DQ 1, for the record. The subtype of DQ 1 does not involve the part of the gene that is involved with M.C. or gs, and thus, practically speaking, we need not concern ourselves with.
My sister is also DQ2, DQ1 (a different subtype than mine) and has the exact same foods she is immunologically sensitive to as I do.
Thanks, Luce
Hi Luce,
Strange, I couldn't find any info about just DQ1, and from your original post I thought you said subtype 6. How did you determine your HLA DQ types? Via enterolab? Could you write down exactly what it said?
The serological equivalent as shown in Bob's example above is what I'm referring to as DQ2 and DQ1 for myself. Using those is just a little bit easier for discussion purposes, is all. (Thank's Bob!).
The subtypes could prove interesting later on, however, who knows?
Give you a good example right now of how the subtyping helped my sister and I, if only out of academic curiosity, and did not change the way we do anything in the way of treating the condition.
By my sister and I having two different subtypes of DQ 1 that we got from my dad, we then knew for sure what his had been, posthumously, since we had done the genotypes of mother and found her to have two of the DQ2's, so we both knew our other one had to be from our dad.
See what your report says after "serological equivalent."
The gluten sensitive, celiac genes are HLA-DQB1*0201 and HLA-DQB1*0302 (HLA-DQ2 and HLA-DQ8, respectively).
The other gluten sensitive genes are any molecular type involving another HLA-DQB1*03 number (i.e., HLA-DQ3), or any HLA-DQB1*05 number, or any HLA-DQB1*06 number (i.e., HLA-DQ1)
Am I right or wrong?
Love,
Tessa
DX Secondary Adrenal Insufficiency= Panhypopituitarism,POTS & MC. Anaphylactic reaction to foods & some drugs.
Gluten & Dairy free diet+hydrocortisone, Florinef, Sea Salt, Vit B Complex, Potassium, Sodium, Magnesium...
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
I have to chime in here and say that one can be gluten sensitive and have no symptoms at all! That is the case with me and, Dr. Fine feels, with many others. The intestine is still being damaged from ingesting any little bit of gluten. I had several of his tests and one showed intestinal damage.
I don't mean to scare you - but maybe this will help in your discussions with the kids.
Thanks for posting that information. Are you sure that first allele is 202, or could it possibly be 201? The reason I ask, is because 201 is the most common celiac gene, but I nave no idea what 202 might represent. Did the lab report say what it was? Maybe they had a typo in the report.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Thanks. Apparently those are both non-celiac genes that predispose to gluten sensitivity.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
I just got my results today. The gene results are as follows:
HLA-DQB1 Molecular analysis, Allele 1 0202
HLA-DQB1 Molecular analysis, Allele 2 0301
Serologic Equivalent: HLA-DQ 2,3 (Subtype 2,7)
I don't understand all that but the report said:
HLA gene analysis reveals that you have two copies of a gene that predisposes to gluten sensitivity.
When the eagles are silent, the parrots begin to jabber"
-- Winston Churchill
I've only been back from LA long enough to catch up on much needed sleep and had no time to do anything else while there. I got my results on 12/8. Baby is colicky so now I'm wondering if my daughter also has this. All I can say is that I am SO glad I went GF in August. I've been on the protocol my ND and I came up with for 6 wks now. I have NO D, haven't for over a month and nearly every "issue" I've had for YEARS is gone. I'm now contacting my siblings about this and the list of intestinal issues in just one sister's children and grandchildren is textbook celiac. Her DIL, (the mother of her grandchildren with GI problems) died of breast cancer. Every one of my 9 siblings has had problems with auto-immune disorders.
This is what my test showed:
A) Gluten Sensitivity Stool and Gene Panel Complete *Best test/best value
Fecal Anti-gliadin IgA: 32 Units
Fecal Anti-tissue Transglutaminase IgA: 21 Units
Quantitative Microscopic Fecal Fat Score: Less than 300 Units
Fecal Anti-casein (cow's milk) IgA: 8 Units
HLA-DQB1 Molecular analysis, Allele 1: 0501
HLA-DQB1 Molecular analysis, Allele 2: 0603
Serologic equivalent: HLA-DQ 1,1 (Subtype 5,6)
Interpretation of Fecal Anti-gliadin IgA (Normal Range is less than 10 Units): Intestinal antigliadin IgA antibody was elevated, indicating that you have active dietary gluten sensitivity. For optimal health, resolution of symptoms (if you have them), and prevention of small intestinal damage and malnutrition, osteoporosis, and damage to other tissues (like nerves, brain, joints, muscles, thyroid, pancreas, other glands, skin, liver, spleen, among others), it is recommended that you follow a strict and permanent gluten free diet. As gluten sensitivity is a genetic syndrome, you may want to have your relatives screened as well.
Interpretation of Fecal Anti-tissue Transglutaminase IgA (Normal Range is less than 10 Units): You have an autoimmune reaction to the human enzyme tissue transglutaminase, secondary to dietary gluten sensitivity.
Interpretation of Quantitative Microscopic Fecal Fat Score (Normal Range is less than 300 Units): Provided that dietary fat is being ingested, a fecal fat score less than 300 indicates there is no malabsorbed dietary fat in stool indicating that digestion and absorption of nutrients is currently normal.
Interpretation of Fecal Anti-casein (cow's milk) IgA (Normal Range is less than 10 Units): Levels of fecal IgA antibody to a food antigen greater than or equal to 10 are indicative of an immune reaction, and hence immunologic "sensitivity" to that food. For any elevated fecal antibody level, it is recommended to remove that food from your diet. Values less than 10 indicate there currently is minimal or no reaction to that food and hence, no direct evidence of food sensitivity to that specific food. However, because 1 in 500 people cannot make IgA at all, and rarely, some people can still have clinically significant reactions to a food antigen despite the lack of a significant antibody reaction (because the reactions primarily involve T cells), if you have an immune syndrome or symptoms associated with food sensitivity, it is recommended that you try a strict removal of suspect foods from your diet for up to 12 months despite a negative test.
Interpretation Of HLA-DQ Testing: Although you do not possess the main HLA-DQB1 genes predisposing to celiac sprue (HLA-DQB1*0201 or HLA-DQB1*0302), HLA gene analysis reveals that you have two copies of a gene that predisposes to gluten sensitivity (any DQ1, DQ2 not by HLA-DQB1*0201, or DQ3 not by HLA-DQB1*0302). Having two copies of a gluten sensitive gene means that each of your parents and all of your children (if you have them) will possess at least one copy of the gene. Two copies also means there is an even stronger predisposition to gluten sensitivity than having one gene and the resultant immunologic gluten sensitivity may be more severe.
Resolved MC symptoms successfully w/L-Glutamine, Probiotics and Vitamins, GF since 8/'09. DX w/MC 10/'09.
