Autoimmune, Colitis, Endocrine issues

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bobh
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Autoimmune, Colitis, Endocrine issues

Post by bobh »

Immune systems are supposed to fight off infections, and behave themselves when there is nothing for them to do. There has been a wealth of comments on this site about MC being an "autoimmune" issue.

The short definition of "autoimmune" (per onelook.com) is "of or relating to the immune response of the body against substance normally present in the body". Other definitions speak of "the failure of an organism to recognize its own constituent parts (down to the sub-molecular levels) as "self", which results in an immune response against its own cells and tissues." That explanation helped me understand how this colitis happens, why there is inflammation.

I started looking into the "autoimmune" thing, because Marsha's post on 12-16-06 really hit home with some symptoms I have had for years:
Artteacher, Marsha wrote:I have Hashimoto's Thyroiditis. It's a common reason to have low thyroid function due to autoimmune attack on the thyroid gland. It causes the thyroid to work in fits and spurts and can play havoc with your digestion, metabolism and moods. That alone could be causing many of a person's health problems. If you have other hormonal problems with Hashimoto's, like Addison's, or a pituitary problem (causing low or high cortisol, adrenaline, or some other hormones I previously hadn't heard of), the correction of the thyroid problems with supplemental thyroid can mask the adrenal and pituitary problems.
The thyroid is sometimes referred to as the "gas pedal" for the body. Personally, sometimes I feel like someone "turned the motor off". I have days where I have to really force myself to think, then other days where I feel like a rocket scientist. Over the last 10 years, I have seen lots of MD's, done lots of tests, my various thyroid levels tend to be at "low normal".

I have been prescribed various thyroid meds to see if it makes me feel better, like Cortef, and Armor's. Typically I will feel better for a day or so, then get a "toxic" sort of feeling and end up stopping the meds.

Again, Marsha's comment "causes the thyroid to work in fits and spurts" makes so much sense to me, and when I did further reading on autoimmunity http://en.wikipedia.org/wiki/Autoimmune I could see the broader implication. http://en.wikipedia.org/wiki/List_of_au ... e_diseases talks about celiac disease, and ulcerative colitis (MC should also be on the list, but was overlooked).

So where am I going with all of this? Some people have successfully obtained remission from their colitis by avoiding foods that trigger their conditions. Others, like me, can eat like a saint, and get punished by a sinner. Luckily Entocort can control my symptoms, because there is no "cure" for MC. The Entocort TREATS THE SYMPTOMS, but is not a cure.

My research today led to the understanding that there is NOT A CURE for any of the autoimmune diseases (though there are some meds that "lessen" the immunity, which makes you more susceptible to infections). I experienced a sort of relief, like I don't have to keep looking for a "cure" that isn't there. A part of me can just relax, and focus on moderating SYMPTOMS.

I can think of at least 3 of you who have posted from time to time with endocrine system problems (thyroid, adrenal, etc.) Personally, I am very certain that autoimmune is the reason for most of my health issues. My genetic testing at Dr. Fines = celiac from both parents, and my grandmother had serious autoimmune diseases.

I am curious if any of you with endocrine issues have actually found something that helps you. Entocort helps my MC, but I have found nothing that helps with the "wipe out", and lack of energy that comes and goes. I realize that this post is not relevant to many of you that don't have endocrine issues - but again - it may jog someone to put 2 + 2 together if you have other non-colitis issues.
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Post by harvest_table »

Bob,

B-12 1000 with folic acid has helped me alot.
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Post by bobh »

Great! What brand works for you? Where do you get it?
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Post by tex »

Bob,

I use Solaray brand, which is available in most health food stores in these parts, (and probably most other vitamin vendors, though I haven't looked around). It does contain Sorbitol, natural flavors, and Magnesium Stearate, but it works great for me. It's sublingual, (dissolves under the tongue), and the natural flavor is natural cherry flavor.

I'm not sure which brand Joanna is referring to, but that particular version, (and the one that I usually use), contains 400 mcg of folic acid. It's available in other formulations, for example, 5,000 mcg of B-12, but since the recommended upper limit on folic acid is 800 mcg, that one comes without any folic acid. In place of magnesium stearate, it contains stearic acid, and it also contains silica, citric acid, and malic acid. I'm pretty sure the malic acid, (the acid found in apples), enhances absorption.

Tex
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It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
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Post by bobh »

Thanks folks. At the risk of exposing my ignorance... What does B-12 have to do with the Autoimmune thing?

I have seen mention of B-12 often in the older posts on this site. And I have had B-12 injections years ago that seemed to help my brain fog, then tried them again last year without much result, have taken B-12 sub-linguals (from Twin Lab) and couldn't tell if they were doing anything...

Now that I have poured cold water on the subject - what does the B-12 do?
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Post by tex »

Well, B-12 is an interesting issue. Our bodies don't require a great deal of it, (we only need a few micrograms per day - that's micrograms, not milligrams), and most people who eat a reasonable amount of animal products, ingest plenty of it. The body can store it for long periods of time, also - even years. For example, it can take as long as 20 years for a deficiency to show up, after our bodies stop producing/absorbing it.

B-12 deficiencies can occur because of a folic acid deficiency, pernicious anemia, or a severe malabsorption problem. Various autoimmune diseases that impair the proper function of the gut, tend to cause B-12 deficiency problems. Many of us have/had a severe malabsorption problem due to villous atrophy caused by years of untreated gluten sensitivity. Because of that, we have, (or had), a problem absorbing enough B-12 for many years, and we often show a significant response to sublingual B-12.

If you don't notice a significant response to B-12, then you probably don't need to worry about supplementation.

Tex
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It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
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Post by mle_ii »

I can't remember anything about B-12 and autoimmune. But B12 is important for us in that I would bet most of us are low due to malabsorption issues and also the bacteria in our intestines. I am low and take a B-12 sublingual here and there as well as getting a shot every once in a while.

Though I can't think of out it would specifically help autoimmune it definitly helps with digestion, energy, fatigue, mental issues among others as well.

Finally, make sure that the sublingual form is the Methyl version (Methylcobalamin) as it's easier for the body to absorb and use.

Mike
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Post by harvest_table »

I have been taking a sublingual B12 supplement each morning for 9 weeks and have noticed a significant increase in my mental clarity, alertness and increased physical stamina. It has helped me so much with the "brain fog" Bob mentioned which also seemed to just hang on and come at go at whim over the years.

The brand I'm taking now is GNC, B-12 1000mcg with 400mcg folic acid. Ironic, the label says no sugar, no starch, no artificial colors, no preservatives, sodium free, no wheat, no gluten, no soy, no dairy, and yeast free yet.....yikes, it does contain sorbitol, mannitol, artificial flavors and aspartame! I dabbled with a couple other brands and dosages and have found the best results with this one. (This is in the cyanocobalamin form?)

I've noticed such a remarkable improvement taking this supplement on a daily basis that I was considering starting a thread about it so I'm glad you brought this up Bob. From what I've read, it can take up to 4-8 weeks for some folks to respond.

B-12's THE BOMB, as my daughter would say! As a side note, a small canker sore I've had in my mouth for amost a year which puzzled me has totally disappeared. I've read that these are oftens signs of B-12 difficiencies.

Love,
Joanna
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Post by bobh »

Awesome. Thank you for taking the time to explain that - I'm gonna give it a try!
Bob H
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