Peg,
I didn't quit "for me". I probably never would have. I quit when my husband did after he had open heart surgery. I knew how much he loved to smoke (still threatens to go back to it) so I figured I could last as long as he did. We are both still non-smoking and its been over 3 years. I still want one quite badly at times but it passes.
Anyway, I can understand how you feel, Peg.
I took Prilosec then Nexium for several years. No doctor ever tested for amount of stomach acid. Same for my husband. He's been taking them for many years. Still is. Never been tested. Seems the only requirement for most docs is that you have heartburn. I'm glad I finally got off them. I still have heartburn fairly often though. Mostly when I eat bread or dairy.
Love, Shirley
Back on bile again
Moderators: Rosie, Stanz, Jean, CAMary, moremuscle, JFR, Dee, xet, Peggy, Matthew, Gabes-Apg, grannyh, Gloria, Mars, starfire, Polly, Joefnh
I don't believe that I was tested for bile/acid except during the gallbladder testing. (gallbladder has been removed - not functioning). I have had acid reflex for many, many years with acid burning my esophegus to the point of entering the back of my throat and mouth. Something as simple as drinking water could start the reflex.
I have taken both Nexium and Prilosec and if I miss one dose I notice a huge difference. Hmmmm
The reason for the perscription was because they were concerned that I would cause damage to the throat and esophegus.
Mars
I have taken both Nexium and Prilosec and if I miss one dose I notice a huge difference. Hmmmm
The reason for the perscription was because they were concerned that I would cause damage to the throat and esophegus.
Mars
"Let us rise up and be thankful, for if we didn't learn a lot today, at least we learned a little, and if we didn't learn a little, at least we didn't get sick, and if we got sick, at least we didn't die; so, let us all be thankful." -- Buddha
Mars,
I'm not saying that you have low stomach acid, (the doctors really should test for that, instead of just assuming that it's high), but the reason why drinking water can trigger reflux action, is because it dilutes your stomach acid.
Love,
Tex
I'm not saying that you have low stomach acid, (the doctors really should test for that, instead of just assuming that it's high), but the reason why drinking water can trigger reflux action, is because it dilutes your stomach acid.
Love,
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
AH HA!!!!!!!! Now I get it! LOL Drugs must be messing with my comprehension! 
me up again! hahahahahaha
Love,
Mars
me up again! hahahahahahaLove,
Mars
"Let us rise up and be thankful, for if we didn't learn a lot today, at least we learned a little, and if we didn't learn a little, at least we didn't get sick, and if we got sick, at least we didn't die; so, let us all be thankful." -- Buddha
Ok, I don't quite know what to make of this study, but boy is it interesting. Let's see, we've got the liver, bile, glutathione and opioids.
http://www.ncbi.nlm.nih.gov/entrez/quer ... med_DocSum
Endogenous opioids modulate hepatocyte apoptosis in a rat model of chronic cholestasis: the role of oxidative stress.
http://www.ncbi.nlm.nih.gov/entrez/quer ... med_DocSum
Endogenous opioids modulate hepatocyte apoptosis in a rat model of chronic cholestasis: the role of oxidative stress.
Aims/Background: There are increasing number of evidences indicating the contribution of endogenous opioids in the pathophysiology of cholestatic liver disease. The aim of the present study was to determine the role of the endogenous-opioid system in the modulation of hepatocytes apoptosis and liver oxidant/anti-oxidant balance during chronic cholestasis in rats. Methods: We induced cholestasis in rats by bile duct ligation (BDL). Naltrexone, an opioid antagonist, was administered at different doses (2.5, 5, 10, 20 and 40 mg/kg/day) to cholestatic animals for 5 weeks. Results: Naltrexone prevented the cholestasis-induced decrease of hepatic glutathione levels at higher doses (20 and 40 mg/kg/day). In the next phase of the study, we evaluated the effects of 20 mg/kg/day naltrexone treatment on hepatic damage indices and liver oxidant/anti-oxidant balance in 5-week BDL rats. There was a marked increase in the number of apoptotic hepatocytes as well as serum liver enzymes and hepatic lipid peroxidation levels in cholestatic rats compared with sham-operated animals 5 weeks after the operation. Liver anti-oxidant enzyme activities were significantly reduced in cholestatic rats compared with controls. Chronic treatment with naltrexone significantly improved all the aforementioned indices in comparison with saline-treated cholestatic rats. Conclusion: Our findings demonstrate that the administration of opioid antagonist is protective against hepatic damage in a rat model of chronic cholestasis. We suggest that increased levels of endogenous opioids contribute to hepatocytes apoptosis in cholestasis, possibly through downregulation of liver anti-oxidant defense.
Mike,
It appears to me that they're just saying that they have demonstrated that reversing the effects of opioids, can prevent the death of functional liver cells, (which would normally occur when the bile duct is obstructed).
Tex
It appears to me that they're just saying that they have demonstrated that reversing the effects of opioids, can prevent the death of functional liver cells, (which would normally occur when the bile duct is obstructed).
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
No, just the opposite. That it appears that morphine (the ones produced by the body) appear to block the antioxident (or reduce it) such that the bile becomes toxic and does damage.Reggie wrote:Help me out Mike, I'm on a ton of morphine right now for pelvic pain so it's relevant and I'm too brain dead to understand. Is this saying opiods are a good thing for glutathione and colons?
And to follow up with my thoughts on this to Tex and you...
To be clear though this may or not relate to what is going on here with us. Obviously it isn't to the same level, that is unless your bile duct gets blocked or something causes bile to back up and not get out of the liver or gallbladder. It then gets to such toxic levels that your body starts producing it's own pain killers. Once these pain killers of the body start working they stop the bodies own anti oxidents from working. Once the antioxidents stop working then we start to get liver destruction occuring. What they found that is if they blocked the body from sensing that morphine was there (the antagonist) the antioxident levels went back up and the liver was protected from damage.
