What is Glucagon-like peptide-2 (GLP-2)?

mle_ii · Post by **mle_ii** » Wed Jun 22, 2005 12:32 pm

Some interesting articles got me wondering about this. What exactly produces it and might one increase production of it?

Thanks,
Mike

mle_ii · Post by **mle_ii** » Wed Jun 22, 2005 12:42 pm

Well, to answer my own question.

Here's an interesting article I found:
Glucagon-Like Peptide 2: A Nutrient-Responsive Gut Growth Factor

And here's the article that got me intrested in GLP2:
Stress Impairs Murine Intestinal Barrier Function: Improvement by Glucagon-Like Peptide-2

Polly · Post by **Polly** » Wed Jun 22, 2005 12:49 pm

Mike,

Thanks for these interesting links. Will read them in more detail tonight. Peptides may hold the key I think. Remember, the treatment to counteract zonulin in Dr. Fasano's research is a peptide he developed.

Polly

mle_ii · Post by **mle_ii** » Wed Jun 22, 2005 1:00 pm

Polly wrote:Mike,

Thanks for these interesting links. Will read them in more detail tonight. Peptides may hold the key I think. Remember, the treatment to counteract zonulin in Dr. Fasano's research is a peptide he developed.

Polly

Very interesting indeed. I wonder if it's the same or related peptide?

From what I've read thus far it appears that starches/carbohydrates, fiber and Shot Chain Fatty Acids (SCFA) increase production of GLP2. Also, from what I've read SCFA are actually used in an enemia for folks who have had lower bowel surgery among other things. SCFA appear to be a component of buttermilk/butter and can be produced from starches.

Anyone know more about SCFAs? I'm googling right now. :)

mle_ii · Post by **mle_ii** » Wed Jun 22, 2005 1:05 pm

Holy Cow Batman!

I just came across another interesting tibit about SCFAs.

Colon bacteria need fibre to feed healthy digestion

good bacteria in the colon produce an enzyme that breaks down glucose found in the cell walls of vegetables, fruits and cereals, and which cannot be digested in the small intestine. In the oxygen-less environment of the bacteria-packed colon, bacteria ferment this glucose to use for energy which also results in the production of short-chain fatty acids, the preferred nutrients for colon cells.

fruits and vegetables are beneficial and why antibiotics, which wipe out good bacteria along with bad, should only be taken when absolutely necessary as they upset the model and colonic cells.

Veddy interestink!

mle_ii · Post by **mle_ii** » Wed Jun 22, 2005 4:40 pm

Haven't had time to read it yet, but here's an article on SCFAs:
Short-Chain Fatty Acids and Human Colonic Function: Roles of Resistant Starch and Nonstarch Polysaccharides

ronipow · Post by **ronipow** » Wed Jun 22, 2005 4:46 pm

mike have you read," Breaking the Viscious Cycle"? Since your doing all of this research I think you might find it interesting?

Roni

mle_ii · Post by **mle_ii** » Thu Jun 23, 2005 10:32 am

ronipow wrote:mike have you read," Breaking the Viscious Cycle"? Since your doing all of this research I think you might find it interesting?

Roni

Haven't read it, but I'll look it up. Thanks Roni! Mike

Peggy · Post by **Peggy** » Thu Jun 23, 2005 11:24 am

mle_ii wrote:
Haven't read it, but I'll look it up. Thanks Roni! Mike

I have a copy I can mail you if you like. Email me your mailing address at pwilson@bctf.ca and I get it off in the mail on Monday.

Peg

moremuscle · Post by **moremuscle** » Thu Jun 23, 2005 7:37 pm

Hi Mike and Peggy,

Wow, Mike you are into researching this thing, aren;t you?! Good!! I wish I had time to look at your links right now - perhaps later.

Peggy (librarian in disguise), if you have an extra copy of "Breaking the Vicious Cycle" I would love to receive it in the mail. It is on the list of books I really want to read. Just in case....

Love,
Karen