Basically for anyone with an opinion-
I was taking Entocort during the time I submitted my samples to DR Fine and I am wondering if that could have possibly skewed the results any? Would it possibly make the counts lower than they actually are?
Also after being GFCF for about a year if I were tested again would I get the same results?
Enterolab tests while taking Entocort
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Enterolab tests while taking Entocort
Dr Fine test shows positive for gluten and casien but negative for soy, eggs, and yeast
Maybe its UC maybe its MC? Who knows at this point, but at least I know my intollerances now... so heres to the road to healing!
Maybe its UC maybe its MC? Who knows at this point, but at least I know my intollerances now... so heres to the road to healing!
Good question - I would suspect that Entocort might affect the results, since it suppresses inflammation, but I'm just guessing. That would be a good question to submit to Dr. Fine, by way of an e-mail.
According to what Phyllis Zermeno, (Clinical Manager at Enterolab), told me, when I discussed the possibility of testing for avenin, (oats), intolerance with her, last spring, gluten antibodies will continue to show up in stool tests for at least a year after cutting all gluten out of the diet, whereas most other antibodies will begin to disappear within a few weeks after the allergen is removed from the diet. Therefore, if it has been not much more than a year since you started the GF diet, you should still test positive for gluten intolerance, but your test results for everything else should be negative, (unless you have been ingesting any of those other trigger foods, within a few weeks prior to submitting a test sample). After a year and a half to two years on a strict diet, you should show negative results to a gluten test on a stool sample.
Incidentally, their gluten test is very specific. It will detect only antibodies to gluten, (the prolamin in wheat). It will not detect antibodies to secalin, (the prolamin in rye), nor will it detect antibodies to hordein, (the prolamin in barley), nor antibodies to avenin, (the prolamin in oats). Therefore, if you suspect that you are intolerant to oats, there is no test to detect it - you have to do it the way I went about it, by actual trial and error.
I would assume that applies to the blood tests for celiac disease, also - IOW, the serum test detects only antibodies to gluten, (the prolamin in wheat). When you read all the published information about gluten testing, you get the clear impression that the test will accurately tell you whether you are sensitive to the prolamins in wheat, barley, rye, and/or oats. However, that's simply not true - the test is specific for antibodies to the prolamin in wheat, only, namely gluten. It provides no direct information about any sensitivity to the prolamins in barley, rye, and/or oats. That association has been implied by fiat, which is an unfortunate distortion of the actual facts.
Tex
According to what Phyllis Zermeno, (Clinical Manager at Enterolab), told me, when I discussed the possibility of testing for avenin, (oats), intolerance with her, last spring, gluten antibodies will continue to show up in stool tests for at least a year after cutting all gluten out of the diet, whereas most other antibodies will begin to disappear within a few weeks after the allergen is removed from the diet. Therefore, if it has been not much more than a year since you started the GF diet, you should still test positive for gluten intolerance, but your test results for everything else should be negative, (unless you have been ingesting any of those other trigger foods, within a few weeks prior to submitting a test sample). After a year and a half to two years on a strict diet, you should show negative results to a gluten test on a stool sample.
Incidentally, their gluten test is very specific. It will detect only antibodies to gluten, (the prolamin in wheat). It will not detect antibodies to secalin, (the prolamin in rye), nor will it detect antibodies to hordein, (the prolamin in barley), nor antibodies to avenin, (the prolamin in oats). Therefore, if you suspect that you are intolerant to oats, there is no test to detect it - you have to do it the way I went about it, by actual trial and error.
I would assume that applies to the blood tests for celiac disease, also - IOW, the serum test detects only antibodies to gluten, (the prolamin in wheat). When you read all the published information about gluten testing, you get the clear impression that the test will accurately tell you whether you are sensitive to the prolamins in wheat, barley, rye, and/or oats. However, that's simply not true - the test is specific for antibodies to the prolamin in wheat, only, namely gluten. It provides no direct information about any sensitivity to the prolamins in barley, rye, and/or oats. That association has been implied by fiat, which is an unfortunate distortion of the actual facts.
Tex
Ok I got a response from Enterolab (one day turn around)
This message has been sent by EnteroLab related to the information you have requested.
Your Question: Hello Dr Fine- First off thanks for your tests!! If it werent for them my DR would be still feeding me pills. I wanted to know if Entocort (steroid used for microscopic colitis and other IBD) would in any way change the results of a stool test for gluten, dairy, soy, yeast, and eggs? My tests showed elevated gluten (around 35) and casein (around 18) scores but everything else was normal. Could the Entocort have "lowered" my score for the antibodies? Thank you Andrew
Response: Dear Andrew, Thank you for your correspondence. I will be certain to pass your kind words on to Dr. Fine. Steroid use does not usually affect our tests, unless prolonged use has caused general immunosuppression. This is not usually the case unless someone is taking immunosuppressant medications in situations like transplants or chemotherapy. Prescribed use of Entocort, therefore, should not have lowered the antibody counts of any of your tests. Please let me know if there is anything else I can do for you. Sincerely, Phyllis Zermeno, RN, BSN Clinical Manager
So that is good enough for me.
This message has been sent by EnteroLab related to the information you have requested.
Your Question: Hello Dr Fine- First off thanks for your tests!! If it werent for them my DR would be still feeding me pills. I wanted to know if Entocort (steroid used for microscopic colitis and other IBD) would in any way change the results of a stool test for gluten, dairy, soy, yeast, and eggs? My tests showed elevated gluten (around 35) and casein (around 18) scores but everything else was normal. Could the Entocort have "lowered" my score for the antibodies? Thank you Andrew
Response: Dear Andrew, Thank you for your correspondence. I will be certain to pass your kind words on to Dr. Fine. Steroid use does not usually affect our tests, unless prolonged use has caused general immunosuppression. This is not usually the case unless someone is taking immunosuppressant medications in situations like transplants or chemotherapy. Prescribed use of Entocort, therefore, should not have lowered the antibody counts of any of your tests. Please let me know if there is anything else I can do for you. Sincerely, Phyllis Zermeno, RN, BSN Clinical Manager
So that is good enough for me.
Dr Fine test shows positive for gluten and casien but negative for soy, eggs, and yeast
Maybe its UC maybe its MC? Who knows at this point, but at least I know my intollerances now... so heres to the road to healing!
Maybe its UC maybe its MC? Who knows at this point, but at least I know my intollerances now... so heres to the road to healing!
Andrew,
Thanks for posting that. That's good information to know, for future reference.
Mike,
I guess that shows how much we know.
Tex
Thanks for posting that. That's good information to know, for future reference.
Mike,
I guess that shows how much we know.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Wow Tex... you mean that you dont know it all?!? just kidding- you know much more than I do and i am glad I finally gave you a piece of knowledge.
Dr Fine test shows positive for gluten and casien but negative for soy, eggs, and yeast
Maybe its UC maybe its MC? Who knows at this point, but at least I know my intollerances now... so heres to the road to healing!
Maybe its UC maybe its MC? Who knows at this point, but at least I know my intollerances now... so heres to the road to healing!
Sorry, that didn't convince me. I still think that it could have an effect. Pose the question again, perhaps getting it to Dr Fine, with regards to glucocorticoides -> lower inflamation -> less leaky gut -> fewer antibodies. Not a stretch by any means.tex wrote:Andrew,
Thanks for posting that. That's good information to know, for future reference.
Mike,
I guess that shows how much we know.
Tex
Mike,
I don't follow your statement that lower inflammation means less leaky gut. Leaky gut is caused by elevated zonulin levels, (which causes the tight junctions to open), while inflammation is caused by increased lymphocytic infiltration, (between the cells of the epithelium). Those are two unrelated events, aren't they?
Incidentally, here's an interesting research report I ran across, that shows that a zonulin increase, precedes the development of diabetes - pretty profound stuff:
http://diabetes.diabetesjournals.org/cg ... /55/5/1443
Tex
I don't follow your statement that lower inflammation means less leaky gut. Leaky gut is caused by elevated zonulin levels, (which causes the tight junctions to open), while inflammation is caused by increased lymphocytic infiltration, (between the cells of the epithelium). Those are two unrelated events, aren't they?
Incidentally, here's an interesting research report I ran across, that shows that a zonulin increase, precedes the development of diabetes - pretty profound stuff:
http://diabetes.diabetesjournals.org/cg ... /55/5/1443
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.