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This study seems to agree with one of my theories about CD. My guess is that it would effect other diseases as well. And I bet if they were to do further research they'd find that more of these related diseases follow the mother since she's the inital "seed" of gut bacteria.
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
Objective. In celiac disease (CD), enteropathy of the small bowel results from a T-cell-mediated reaction to gluten in the diet. In addition to gluten, other environmental and genetic factors participate in the disease pathogenesis. We have recently reported the finding of a significantly different short-chain fatty acid (SCFA) profile in fecal samples from children with CD compared to healthy controls reflecting an aberrant gut microflora. The aim of the present study was to make a functional evaluation of the gut microflora status in non-celiac 1st degree relatives of children with CD. Material and methods. Fecal samples from 76 symptom-free, non-celiac, 1st degree CD relatives and from 91 aged-matched healthy controls were analyzed for fecal tryptic activity (FTA) and a number of SCFAs. Results. There was a significantly lower level of acetic acid and total SCFAs as well as a significantly increased level of i-butyric acid and FTA in relatives compared to healthy controls. Conclusions. The FTA and the SCFA profiles in fecal samples from 1st degree relatives of children with CD are different from those of healthy individuals. The implication of this observation provides insight into the pathogenesis of CD and opens up the possibility of future new diagnostic, therapeutic and prophylactic strategies.
Well that research certainly sheds some light on the subject, doesn't it.
Very interesting.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
I think I've mentioned this before, but this sort of stuff makes me wonder about all of the diseases that we think are genetic where in fact they may be due to environmental issues like this one.
Could be, but looking at it another way, maybe the differences in fecal tryptic activity and short-chain fatty acid profiles, (and the aberrant gut microflora), of first-degree relatives of children with celiac disease, compared with healthy controls, are caused by genetic effects/defects.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
tex wrote:Could be, but looking at it another way, maybe the differences in fecal tryptic activity and short-chain fatty acid profiles, (and the aberrant gut microflora), of first-degree relatives of children with celiac disease, compared with healthy controls, are caused by genetic effects/defects.
Tex
Ha! Good point. Though given the numbers I'm more inclined to say that the majority of diseases are environmental rather than genetic. As environment effects genetics as well.
FWIW, I think you're right. After all, most genetic issues require some sort of "trigger", or special conditions, before they become activated.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
