Key Enzyme In Gut Found To Be A Peacemaker In Zebrafish Stud

[mle_ii]

My mom clipped out an article and gave it to me while visiting last week. It was about Intestinal Alkaline Phosphatase. It appears to play a role in detoxing lipopolysaccharides/endotoxins caused by bacteria. Seems it might also play a role in Inflamitory Bowel Disease, Bactierial Overgrowth, Diabeties, Celiac Disease, High Cholesterol, alcohol induced disease, Obesity and even more I'm sure.

http://www.medicalnewstoday.com/articles/91665.php
Key Enzyme In Gut Found To Be A Peacemaker In Zebrafish Study

University of Oregon scientists, using zebrafish to study the gastrointestinal tract, say that an enzyme long assumed to be involved in digestion instead is a detoxifying traffic cop, maintaining a friendly rapport between resident gut bacteria and cells.A deficiency of the enzyme, intestinal alkaline phosphatase (Iap), said Karen Guillemin, a professor of molecular biology, appears to change the playing field inside the gut.

Here's the orginal study:
http://www.ncbi.nlm.nih.gov/sites/entre ... h=18078689

Here's the full pdf version of the study:
http://download.cellhostandmicrobe.com/ ... 002806.pdf

[mle_ii]

Celiac Disease:
http://www.curehunter.com/public/pubmed7424078.do

[tex]

Interesting. That appears to be something that should be routinely included in the testing regimen anytime a patient undergoes tests aimed at discovering the reasons for diarrhea due to unknown causes.

Tex

[mle_ii]

I think you're right Tex. Though I'm still not sure that it would show in blood testing.

Oh and by they way there are a few more interesting things about this.

This enzyme appears to be higher in the blood in folks with a blood type O or B. Though intestinal levels appear to be the same.
http://www.ncbi.nlm.nih.gov/sites/entre ... ch=1777990

Vitamin K increases IAP:
http://www.ncbi.nlm.nih.gov/sites/entre ... h=17874826

Fish oil (and other oils) also increases IAP:
http://www.ncbi.nlm.nih.gov/sites/entre ... h=15599000

At one point I found an article that Vitamin D played a role as well. It also appears that lactose increases production of this enzyme. Perhaps that's because lactose is a polysaccharide.

[mle_ii]

And it appears that mercury can inhibit this enzyme along with the other enzymes of the gut.

In vitro inhibition of digestive enzymes by heavy metals and their reversal by chelating agent: Part I. Mercuric chloride intoxication.
http://www.ncbi.nlm.nih.gov/pubmed/107987

Though I wouldn't recommend EDTA as a chelator for mercury.

[mle_ii]

And back to Intestinal Alkaline Phosphatase, it appears that Coumestrol can lower levels of this.

http://en.wikipedia.org/wiki/Coumestrol

And look at what contains the largest amounts of Coumestrol, soybeans. I knew I didn't like em. Appears that Legumes also contain this, among other foods.

Here's the study linking Coumestrols effects on IAP.
http://www.jstage.jst.go.jp/article/jrd ... 00032/_pdf

Though reading this it appears that it seems to only have an effect in pregnant animals, and not neonatal.

Mike

[tex]

Hmmmmmmmmmm.

Tex