Food Doc update on VLS#3

starfire · Post by **starfire** » Mon Jan 28, 2008 6:59 am

http://thefooddoc.blogspot.com/2008/01/ ... -only.html

Since I had posted the first one I thought I should go ahead and post this one also. Someone might need the info.

Love, Shirley

Post by **tex** » Mon Jan 28, 2008 10:04 am

Thanks Shirley,

That's a great primer on VLS#3, and should be a "must read" for all of us.

Obviously, this sentence contains a misprint:

Since the over the counter flavored sachet packets of VSL#3 contain maltose derived from barley as a sweetener they can be assumed gluten-free.

I have no doubt that he intended to say "they can not be assumed gluten-free".

I find this paragraph to be the most intriguing part of the article, however:

In future posts I will review the benefits of probiotic bacteria and yeast. I am also working on an e-book that comprehensively reviews probiotics. These supplements may critical in the prevention and treatment of leaky gut. Increased gut permeability or leaky gut is increasingly being recognized as the critical predisposing factor to the development of Celiac disease, colitis, Crohn’s disease and several non-digestive autoimmune disorders.

For at least the last couple of years, I have maintained that leaky gut syndrome is the linchpin upon which celiac sprue, MC, and possibly all the IBDs are keyed. Without LGS, they wouldn't be possible, or at least, they couldn't cause the severe systemic symptoms that we have to endure during a reaction. It's gratifying to see that I'm not the only one who feels this way. I'm really looking forward to future developments concerning LGS.

Love,
Tex

starfire · Post by **starfire** » Mon Jan 28, 2008 12:07 pm

Yes, I remember discussions about that subject. I have no reason to doubt it, that's for sure. Something sure kick starts all this stuff.

Love, Shirley

mle_ii · Post by **mle_ii** » Mon Jan 28, 2008 1:00 pm

tex wrote:I find this paragraph to be the most intriguing part of the article, however:

In future posts I will review the benefits of probiotic bacteria and yeast. I am also working on an e-book that comprehensively reviews probiotics. These supplements may critical in the prevention and treatment of leaky gut. Increased gut permeability or leaky gut is increasingly being recognized as the critical predisposing factor to the development of Celiac disease, colitis, Crohn’s disease and several non-digestive autoimmune disorders.
For at least the last couple of years, I have maintained that leaky gut syndrome is the linchpin upon which celiac sprue, MC, and possibly all the IBDs are keyed. Without LGS, they wouldn't be possible, or at least, they couldn't cause the severe systemic symptoms that we have to endure during a reaction. It's gratifying to see that I'm not the only one who feels this way. I'm really looking forward to future developments concerning LGS.

Love,
Tex

And you of course know my thoughts on this. :) I agree 100%. What's interesting is that even non live bacteria will have a benefit. Though, I'm sure he might allude to, the numbers of bacteria in a probiotic are very important. The small numbers you see in most probiotics would only be good for maintainence purposes. The bit that I wrote about a while back on quorum (sp) sensing is part of this, for those who aren't interested in reading about it, it has to do with the way that bacteria can actually communicate with each other, and requires very large numbers of them for this communication to happen, otherwise they "hide". :)

Thanks,
Mike

harvest_table · Post by **harvest_table** » Tue Jan 29, 2008 4:08 pm

tex wrote:For at least the last couple of years, I have maintained that leaky gut syndrome is the linchpin upon which celiac sprue, MC, and possibly all the IBDs are keyed. Without LGS, they wouldn't be possible, or at least, they couldn't cause the severe systemic symptoms that we have to endure during a reaction. It's gratifying to see that I'm not the only one who feels this way. I'm really looking forward to future developments concerning LGS.

This interests me too, just happened upon this.....a new potential therapeutic approach to Inflammatory Bowel Disease.

In the new discovery published in the scientific journal Gastroenterology, the Irish scientists have demonstrated that they can almost completely reverse the symptoms of IBD in a disease model using a new class of drugs known as hydroxylase inhibitors. ‘Under normal conditions our gastro-intestinal tract is lined with cells that block the contents of the gut from leaking into the intestine,’ explains Professor Cormac Taylor from the UCD Conway Institute, University College Dublin, one of the principal scientists involved in the discovery. ‘However, when a person is suffering from IBD this barrier is broken and the contents of the gut leak out into surrounding areas.’

‘When we applied the new drugs, the gut was tricked into thinking that it was being deprived of oxygen and this activated protective pathways which in turn prevented the death of the cells that line the gastrointestinal tract,’ continues Professor Taylor.

While completing their investigation, the Irish researchers became aware of a similar study taking place at the University of Colorado, Denver. This study appears as an accompanying article in the same issue of Gastroenterology. The US study, while using a different hydroxylase inhibitor, supports the Irish scientist’s research findings.

The Irish and US research groups will now begin a collaborative investigation to bring the discovery to the next stage which involves developing a new therapeutic which can be delivered safely to humans.

http://www.sciencecentric.com/news/08011411.htm

Also, along the same lines, it looks like Dr. Fasano just got a big big research boost!

US biopharma firm Alba Therapeutics has received a boost to its coffers after Shire agreed to pay up to $325m (€226m) to help bring its lead gastrointestinal drug candidate to market.

http://www.drugresearcher.com/news/ng.a ... disease-at

It's so great to see progress being made. Good for them, AND us.

Love,
Joanna

Post by **tex** » Tue Jan 29, 2008 8:24 pm

Joanna,

Thanks for those links. It sure looks like there will eventually be a lot more pills on the market to combat these GI issues.

Hmmmmmmm. I didn't realize that the death of epithelial cells, (other than normal apoptosis), was at the core of the "tight junction" problem. That's a whole different slant on the issue.

Love,
Tex

mle_ii · Post by **mle_ii** » Tue Jan 29, 2008 8:52 pm

FWIW I just got my new order of VSL#3 in the mail today. I'm going to give it a try again, but more long term. It'll be interesting to see if it helps with my present symptoms. I'm pretty much back to where I was symptom wise before starting treatment for SIBO.

Matthew · Post by **Matthew** » Tue Jan 29, 2008 9:26 pm

Hello friends.

Saw that the Food Doc recommended Ultimate Flora from Renew Life as an alternative to VSL#3

Did not find much about what was really in it on the web site.

Checked it out at the market while picking up a few vegetables for dinner.

Ultimate Flora 15 Billion says on the package that it contains no gluten, dairy , yeast , corn, binders or fillers.

Ultimate Flora 30 billion says on the package “This package may contain traces of milk and soy proteins from fermentation ingredients . This product is recommended for those on a low- lactose diet.” It also contains FOS just in case that might be a problem for anyone.

I hope this helps for anyone trying to make a decision.

Love

Matthew