Hi Polly,
I'm very interested in reading about what you found on this. Specifically about bacteria needing to be educated before they will adhere to the gut. Where did you read about this? I really want to read more.
Thanks,
Mike
Polly, question on educating bacteria
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Thanks, Polly,
That's an interesting article, but I find the information on the website that he recommends, to be much more interesting, (it supports some of the "radical" concepts that we have maintained were true all along). For example, the author explains why it is next to impossible to get anything other than out-dated treatments from a doctor.
If you're anything like me, after reading those articles on this site, you'll suspect yeast, and/or adverse colonization of gut fauna, as the primary cause for what ails most/all of us.
http://www.yeast-candida-infections-uk.co.uk/
Apparently, it is next to impossible to actually significantly change the permanent gut fauna colonization, on a long-term basis. To me, that implies that my food intolerances, (even gluten), may exist because my gut fauna somehow got out of whack, (maybe I caught a virus, which changed my genes, and/or my metabolism, for example). As long as I avoid those foods, then everything is at peace in my gut. If I eat one or more of those foods, however, then the existing colonies of "toxic" bacteria, multiply at "unlimited" speeds, and once again, they are in control, as long as their preferred substrate, (food), is available to feed them. While they are in control, of course, then I will continue to react.
Yeast can do the same thing, since it's roots can penetrate the tight junctions, and force them to open.
We refer to MC, (and various other linked diseases), as autoimmune diseases. Call me dense, but I've never really been completely sold on the concept of autoimmune reactions. Sure the body is putting out antibodies, but I really believe that they are directed at something other than our own bodies. I believe that the human body and it's control systems, are too sophisticated for true autoimmune reactions to occur. "We", (and by "we" I mean the medical industry as a group, present company excepted), just aren't smart enough to figure out what is really going on, so we have defined the concept known as autoimmune reactions, and we blame "autoimmune" diseases on them.
I'll guarantee that the average doctor couldn't find a GI yeast overgrowth if his/her life depended on it, because he/she is not going to look for it, (since it's a zebra, not a horse). If you can successfully twist their arm, and get them to look for it, some of them can find it, of course, but they're not going to look for it on their own. The same goes for bacterial colonization imbalances. I'm not sure that any of them even know what a proper gut fauna spectrum should consist of - so how in the world would they know if it is out of balance?
Okay, I'm just thinking out loud in this post, but this is very, very interesting stuff, isn't it.
Love,
Tex
P S I totally agree with his observations on the relationship between natural carcinogens and man-made carcinogens, also. Our bodies have "learned" to handle natural carcinogens that are thousands of times more potent than the man-made carcinogens that we blame all our cancer problems on. Why do we routinely assume that these minuscule amounts of man-made compounds are so dangerous, while we trustingly consume massive amounts of natural carcinogens in our food every day? Methinks we like our food just the way it is, so we are constantly in search of "evil" man-made substances to use as scapegoats. I'm not saying that man-made carcinogens are not totally free of blame, but I don't think the natural carcinogens are, either. What bothers me the most is the way we look at the relationship between the two with such a "jaundiced" eye.
That's an interesting article, but I find the information on the website that he recommends, to be much more interesting, (it supports some of the "radical" concepts that we have maintained were true all along). For example, the author explains why it is next to impossible to get anything other than out-dated treatments from a doctor.
If you're anything like me, after reading those articles on this site, you'll suspect yeast, and/or adverse colonization of gut fauna, as the primary cause for what ails most/all of us.
http://www.yeast-candida-infections-uk.co.uk/
Apparently, it is next to impossible to actually significantly change the permanent gut fauna colonization, on a long-term basis. To me, that implies that my food intolerances, (even gluten), may exist because my gut fauna somehow got out of whack, (maybe I caught a virus, which changed my genes, and/or my metabolism, for example). As long as I avoid those foods, then everything is at peace in my gut. If I eat one or more of those foods, however, then the existing colonies of "toxic" bacteria, multiply at "unlimited" speeds, and once again, they are in control, as long as their preferred substrate, (food), is available to feed them. While they are in control, of course, then I will continue to react.
Yeast can do the same thing, since it's roots can penetrate the tight junctions, and force them to open.
We refer to MC, (and various other linked diseases), as autoimmune diseases. Call me dense, but I've never really been completely sold on the concept of autoimmune reactions. Sure the body is putting out antibodies, but I really believe that they are directed at something other than our own bodies. I believe that the human body and it's control systems, are too sophisticated for true autoimmune reactions to occur. "We", (and by "we" I mean the medical industry as a group, present company excepted), just aren't smart enough to figure out what is really going on, so we have defined the concept known as autoimmune reactions, and we blame "autoimmune" diseases on them.
I'll guarantee that the average doctor couldn't find a GI yeast overgrowth if his/her life depended on it, because he/she is not going to look for it, (since it's a zebra, not a horse). If you can successfully twist their arm, and get them to look for it, some of them can find it, of course, but they're not going to look for it on their own. The same goes for bacterial colonization imbalances. I'm not sure that any of them even know what a proper gut fauna spectrum should consist of - so how in the world would they know if it is out of balance?
Okay, I'm just thinking out loud in this post, but this is very, very interesting stuff, isn't it.
Love,
Tex
P S I totally agree with his observations on the relationship between natural carcinogens and man-made carcinogens, also. Our bodies have "learned" to handle natural carcinogens that are thousands of times more potent than the man-made carcinogens that we blame all our cancer problems on. Why do we routinely assume that these minuscule amounts of man-made compounds are so dangerous, while we trustingly consume massive amounts of natural carcinogens in our food every day? Methinks we like our food just the way it is, so we are constantly in search of "evil" man-made substances to use as scapegoats. I'm not saying that man-made carcinogens are not totally free of blame, but I don't think the natural carcinogens are, either. What bothers me the most is the way we look at the relationship between the two with such a "jaundiced" eye.
Hey Tex, speaking of immune/autoimmune issues. Take a look at this:
http://en.wikipedia.org/wiki/Low_dose_naltrexone
And this site to which it links:
http://www.lowdosenaltrexone.org/
I remember some questions as to why smoking plays a role, I wonder if it's somehow related to why they think that low dose naltrexone can help folks with Crohn's Disease and some other autoimmune diseases. I also start to think about the other opoids that we injest, specfically those found in dairy and grains. Might eating these things caused a disconnect in our bodies natrual production of endorphines and thus disregulate the immune process.
Oh, and you might wonder why I even got onto this, I had never heard about Low Dose Naltrexone treatment until yesterday when I met with an internal medicine Dr that I've seen before. I told him that I was getting frustrated with the SIBO and having it come back after taking antibiotics. He thought that it might be an immune issue and thus suggested this, at first I was dismissive of the idea, he did give me a trial prescription, so I figured I'd read more about this. Well it was pretty damn interesting for sure. I think you and Polly and others might think the same after reading it and seeing that there are vaild studies behind it.
Anyway, on to read more about it.
Thanks,
Mike
http://en.wikipedia.org/wiki/Low_dose_naltrexone
And this site to which it links:
http://www.lowdosenaltrexone.org/
I remember some questions as to why smoking plays a role, I wonder if it's somehow related to why they think that low dose naltrexone can help folks with Crohn's Disease and some other autoimmune diseases. I also start to think about the other opoids that we injest, specfically those found in dairy and grains. Might eating these things caused a disconnect in our bodies natrual production of endorphines and thus disregulate the immune process.
Oh, and you might wonder why I even got onto this, I had never heard about Low Dose Naltrexone treatment until yesterday when I met with an internal medicine Dr that I've seen before. I told him that I was getting frustrated with the SIBO and having it come back after taking antibiotics. He thought that it might be an immune issue and thus suggested this, at first I was dismissive of the idea, he did give me a trial prescription, so I figured I'd read more about this. Well it was pretty damn interesting for sure. I think you and Polly and others might think the same after reading it and seeing that there are vaild studies behind it.
Anyway, on to read more about it.
Thanks,
Mike
Ok, I remember talking about this a long time ago, but guess how Loperamide works:
http://en.wikipedia.org/wiki/Loperamide
Well, it is an opioid receptor agonist and acts on the μ-opioid receptors. So given that it seems that some folks here require more and more Loperamide to stop Diarrhea. Might the receptors in these folks require more and more endorphines or other opioids created by the body becase they become desensitized, either the body stops producing it on it's own or something in the body is stopping it's production.
Might this also be a reason why we have more GI pain, as with less production of endorphines mean we would feel more pain.
Ok, I'll stop for now so that others can catch up, and I can read more. :)
Mike
http://en.wikipedia.org/wiki/Loperamide
Well, it is an opioid receptor agonist and acts on the μ-opioid receptors. So given that it seems that some folks here require more and more Loperamide to stop Diarrhea. Might the receptors in these folks require more and more endorphines or other opioids created by the body becase they become desensitized, either the body stops producing it on it's own or something in the body is stopping it's production.
Might this also be a reason why we have more GI pain, as with less production of endorphines mean we would feel more pain.
Ok, I'll stop for now so that others can catch up, and I can read more. :)
Mike
Yep, that is damn interesting! I've never seen that before, either.This theory of LDN's mechanism contradicts the widely-held belief that autoimmune diseases are caused by an overactive immune system.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
It's not an if, but a when. I just started taking a low dose erythromycin to help with motility. I have noticed lately that I was getting more and more constipated, though my diet as of late hasn't been the best as far as that is concerned. Anyway, I'm going to wait about a week or so to make sure that I don't add too many variables at the same time and don't know what causes what.Pat wrote:Mike,
This is all very interesting. Let us know if you decide to take the Naltrexone.
Pat
I thought you'd get a kick out of that. :)tex wrote:Yep, that is damn interesting! I've never seen that before, either.This theory of LDN's mechanism contradicts the widely-held belief that autoimmune diseases are caused by an overactive immune system.
Tex
I really should get a baseline cbc before taking it as I'm wondering if it would increase my low neutrophil counts. They've been hovering down around the neutropenia levels (can cause increased bacterial infections) for quite some time, years I think. My lymphocytes have always been around midrange, but neutrophils make up a much larger number of the white blood cels. They are also responsible for fighting off bacteria and fungus.
Mike