http://www.ncbi.nlm.nih.gov/pubmed/1138 ... d_RVDocSum
I was looking to see if my LC could have been caused by chemo and I found this.....
So, MC can be familial or drug induced?
Familial?
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Joan,
Yes, and yes. It's well documented that MC has been caused by NSAIDs, PPIs, SSRIs, most antibiotics, etc. Researchers, including Dr. Fine, have long suspected an infectious agent in the etiology of MC, but so far, no one has been successful in confirming this, even though there seems to be a relatively strong link with certain bacterial infections such as C. diff, and certain parasites. (A familial connection could be either genetic, or infectious, or both).
As powerful as the concoctions used in chemotherapy usually are, I would be surprised if they don't occasionally lead to MC for some patients.
Tex
Yes, and yes. It's well documented that MC has been caused by NSAIDs, PPIs, SSRIs, most antibiotics, etc. Researchers, including Dr. Fine, have long suspected an infectious agent in the etiology of MC, but so far, no one has been successful in confirming this, even though there seems to be a relatively strong link with certain bacterial infections such as C. diff, and certain parasites. (A familial connection could be either genetic, or infectious, or both).
As powerful as the concoctions used in chemotherapy usually are, I would be surprised if they don't occasionally lead to MC for some patients.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
MO, Tex
Thanks very much.
The most promising thing I found when I Googled about the chemo connection wouldn't open for me. I think it was on Elsivier (sp) or something like that.
The most promising thing I found when I Googled about the chemo connection wouldn't open for me. I think it was on Elsivier (sp) or something like that.
DISCLAIMER: I am not a doctor and don't play one on TV.
LDN July 18, 2014
Joan
LDN July 18, 2014
Joan
A lot of the medical sites seem to charge for information that used to be free. I'm not sure if it's due to greed, or if they're afraid that some of that information might fall into the wrong hands, (namely, patients).
D is a pretty common side effect of chemo treatment, isn't it? Most traditional chemotherapy agents work by triggering programmed cell death, (programmed cell death is a normal cellular process, which is known as apoptosis, in medical circles), and they kill cancer cells by affecting DNA synthesis or function, and some actually alter cellular DNA. Many chemotherapy drugs are genotoxins, meaning that they act by attacking DNA and causing mutations in key oncogenes or tumor suppressor genes. That's pretty profound stuff.
You're most welcome,
Tex
D is a pretty common side effect of chemo treatment, isn't it? Most traditional chemotherapy agents work by triggering programmed cell death, (programmed cell death is a normal cellular process, which is known as apoptosis, in medical circles), and they kill cancer cells by affecting DNA synthesis or function, and some actually alter cellular DNA. Many chemotherapy drugs are genotoxins, meaning that they act by attacking DNA and causing mutations in key oncogenes or tumor suppressor genes. That's pretty profound stuff.
You're most welcome,
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.