Microscopic colitis: a large retrospective analysis from a h

jcc · Post by **jcc** » Sun Jul 12, 2009 9:21 pm

I'm not sure if this has already been posted... I was just catching up on reading my email pubmed feeds after vacation and found this.

Microscopic colitis: a large retrospective analysis from a health maintenance organization experience.

Kao KT, Pedraza BA, McClune AC, Rios DA, Mao YQ, Zuch RH, Kanter MH, Wirio S, Conteas CN.
Department of Gastroenterology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, CA 90027, USA. kevin.t.kao@kp.org

AIM: To examine the demographic data on a large multi-ethnic population of patients with microscopic colitis (MC) in Southern California and to determine the association of MC with inflammatory bowel disease (IBD) and colorectal cancer. METHODS: All patients diagnosed with MC by colonic biopsy from 1996-2005 were identified utilizing a pathology database. All biopsies were reviewed by experienced pathologists utilizing standard histologic criteria. Patients' medical records were reviewed and data regarding patient age, co-morbidities, sex, ethnicity, and medications were analyzed. An age- and sex-matched standard control group was also generated. Chi-square test was used to evaluate the associations of co-morbidities between lymphocytic colitis (LC), collagenous colitis (CC) and the control group. RESULTS: A total of 547 cases of MC were identified, 376 patients with LC and 171 patients with CC. The female/male ratio was 3:1 in CC and 2.7:1 in LC patients. Celiac disease (P < 0.001), irritable bowel syndrome (IBS) (P < 0.001), and thyroid diseases (P < 0.001) were found to have a higher occurrence in MC compared to the control group. No statistical differences in the occurrence of colorectal cancer, diabetes and IBD were found between the MC group and the control group. CONCLUSION: This is the largest group of patients with MC known to the authors that has been studied to date. Conditions such as celiac disease, IBS, and thyroid diseases were found to be related to MC. Furthermore, neither an increased risk of colorectal cancer nor IBD was associated with MC in this study.

PMID: 19575491
http://www.ncbi.nlm.nih.gov/pubmed/19575491

Post by **tex** » Sun Jul 12, 2009 10:05 pm

No, that hasn't been posted here yet, to the best of my knowledge. That's a very interesting study, and it correlates with what we have experienced here, of course.

Thanks for posting that information.

Tex

JLH · Post by **JLH** » Mon Jul 13, 2009 7:43 am

I don't get the last sentence....must be brain fog.

Post by **tex** » Mon Jul 13, 2009 9:37 am

Joan,

I think your brain is working quite well, it's out in Los Angeles where the brain fog is evidently at epidemic levels. Is it any wonder why most medical professionals can't figure out how to deal with MC, when they don't even realize that it's an IBD?

Tex

ant · Post by **ant** » Mon Jul 13, 2009 9:48 am

Aha.. if I understand this correctly this shows a statistically significant link between MC and celiac disease.....Does this study bringing us closer to mainstream acceptance of the importance for diet for MC? Best ant

Post by **tex** » Mon Jul 13, 2009 1:42 pm

Ant wrote:Does this study bringing us closer to mainstream acceptance of the importance for diet for MC?

That's a brand new, just-published research article, so hopefully, it will start the ball rolling, but I don't expect any quick results, in conventional medical circles. Mainstream medicine is traditionally excruciatingly slow to change it's thinking, about something such as this.

Tex