An Association Between Microscopic Colitis and Celiac Disease.
Green PH, Yang J, Cheng J, Lee AR, Harper JW, Bhagat G.
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA.
BACKGROUND & AIMS:: Microscopic colitis (MC), characterized by non-bloody, watery diarrhea, has been associated with celiac disease (CD). We aimed to determine the extent and significance of the relationship between CD and MC. METHODS:: A prospectively maintained database of CD patients, seen between 1981 and 2006, was analyzed. Standardized morbidity ratios (SMR) were calculated using a general population study of MC as the reference group. Statistical analysis was conducted using the Student t-test, Pearson (2) test or Fisher exact test, where appropriate. RESULTS:: MC was found in 44 (4.3%) of 1009 patients; this represented a 45-fold increased risk for individuals with CD have MC, compared to the general population (SMR 45.5(CI 27.7-63.3). The CD patients with MC were older (p = 0.0001) and had more severe villous atrophy (p =0 .002) than the CD patients without MC. MC was diagnosed after CD in 64% of the patients, simultaneously in 25% and before CD in 11% (p=0.0001). Pancolitis predominated, though 16% had colitis limited to the right colon. Steroid or immunosuppressant therapies were required in 66% of the CD patients with MC and as maintenance therapy were given to 50% of these patients. Follow up biopsies revealed that the colitis persisted in 57% of the patients with CD and MC, despite improved diarrhea symptoms. CONCLUSIONS:: MC is more common in patients with CD than in the general population. Patients with CD and MC have severe villous atrophy and frequently require steroids or immunosuppressant therapies to control symptoms.
PMID: 19631283 July 21,2009
http://www.ncbi.nlm.nih.gov/pubmed/19631283
An Association Between Microscopic Colitis and Celiac Diseas
Moderators: Rosie, Jean, CAMary, moremuscle, JFR, Dee, xet, Peggy, Matthew, Gabes-Apg, grannyh, Gloria, Mars, starfire, Polly, Joefnh, mbeezie
