MRT update

Discussions can be posted here about mediator release testing (MRT), as offered by Oxford Biological Technologies, in conjunction with the LEAP program, which is claimed to determine a relative level of sensitivity to various foods and chemicals by measuring an increase in the ratio of liquids to solids in a blood sample that has been exposed to a specific allergen.

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tex
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Post by tex »

Hotrod,

The cortisol issue has to do with the fact that cortisol is used by the body to trigger the well known "fight or flight" response. Here's a quote from an article written by a doctor who gives a very good explanation of how this adversely affects most organs in the body. It answers a lot of questions about why many of us feel the way we do, during an MC reaction.
Cortisol adversely affects the intestinal tract in two ways. First, high cortisol levels shift the nervous system away from digestive function, since you won’t be eating and running or fighting at the same time (unless you are Mike Tyson eating your opponent’s ears). Secondly, cortisol impairs the body’s ability to repair itself because it doesn’t want to spend the energy on this activity when it needs it for the stress response. The end result is a progressive thinning and wearing away of the intestinal lining. So we have a double whammy: an inflamed intestinal tract lining from a poor diet and too many anti-inflammatory drugs, which is then aggravated by having your body produce still more cortisol in response to the intestinal inflammation.
You'll get more out of that quote, of course, if you read the entire article:

http://www.richardweinsteindc.com/disor ... %20Colitis:

I find his remarks about how the thyroid is affected, to be particularly interesting, since so many of us tend to have hypothyroidism. This is a partial quote of that section:
High cortisol levels can both alter pituitary function and prevent the conversion of thyroid hormone, so thyroid function can be compromised on either end of the process.

Far more overlooked is the fact that even if the thyroid hormone makes it to the liver intact to be further processed and released as a useable hormone, the liver ships 20% of the thyroid hormone to the intestinal tract in a deactivated form, where it becomes reactivated. So if the intestinal tract is inflamed, dysfunctional, and unable to reactivate the thyroid hormone, you will be 20% low on thyroid hormone (a condition known as hypothyroidism).

The symptoms of low thyroid function are fatigue, feeling cold especially in the hands and feet, and depression. By not accounting for the 20% loss of thyroid hormone due to intestinal dysfunction, millions of women are being told by their doctors that their thyroid hormone levels are fine even though they have these symptoms, because their blood tests only show the level of thyroid hormone before it gets to the liver to be processed.
The red emphasis is mine, of course.

Presumably, by suppressing high cortisol levels, the body, (and most organs), will be shifted out of "fight or flight" mode, and into normal mode, (which restores the capacity for healing). I'm not sure that everyone with MC automatically has high cortisol levels, but certainly, some of us do.

Tex
:cowboy:

It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
RUBYREDDOG
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Post by RUBYREDDOG »

Luce, Thanks for expressing your point of view. I once had a co-worker who was a heavy smoker. As hard as I tried to get him to quit (being an x-smoker, we are the worst) he refused to listen. His stance was that he was going to enjoy life to the fullest....NOW..... and not worry about the future. Besides, he said, the last few years of life are the crappiest anyway, so who needs that. We lost touch after a few years so I don't know how he is doing now.

In some respects, there is merit to his thinking. (I want to keep this short because it does not really relate to MC). AFter watching my father die a quick death at age 75, and my mother suffer a long painful death at age 85, I would choose to have quality over quantity when it comes to the golden years. Of coarse the big fellow upstairs has the final vote on this issue. Just my view. YMMV

Hotrod
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Post by starfire »

If I had my choice.......... which I don't........... I'd choose quality over quantity no question!!

Love, Shirley
When the eagles are silent, the parrots begin to jabber"
-- Winston Churchill
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Bifcus16
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Post by Bifcus16 »

Hi Tex and Rosie,

You are right of course, it is 200mcg. I didn't have it handy so relied on memory.

Maybe I need to take something for memory. :cool:

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Post by Lucy »

Hotrod,

I know EXACTLY what you mean. My father died suddenly right here in the house. I remember thinking much later on that if I wanted to go quickly, wow, I'd better start eating fried eggs from now on! Too bad I'm allergic to 'em! Ha!

In terms of quality of life, mine has never been better as far as eating is concerned, and I eat better tasting AND better looking food than anyone I know. Even if I were suddenly able to take a pill tomorrow that would prevent me from reacting to the foods I'm sensitive to, I don't think I'd ever go back to the typical American diet for the simple reason that mine tastes so much better. I think I'd continue eating good quality meats, fowl, and seafood and alot more quality fruits and vegetables as my source for carbohydrates as opposed to the more grain based diets people in the USA and other places consume as I've just plain gotten spoiled eating so well the last few years.
I don't think feeling deprived helps anyone in the long run, but it is a stage we all must go through to get to the other side sometimes.

Hang in there, and find some really tasty things that don't make you sick as a reward. You deserve it!

Yours, Luce
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Post by RUBYREDDOG »

Tex,

Thanks for the link on Cortisol. I am going to read the entire article. It is interesting how the hypothyroid issue keeps popping up in relation to MC. The HPT organs work in concert to control so much of our body's function. Hopefully someone will figure this all out someday.

Hotrod
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Post by Gloria »

Mary Beth,
I've finally had time to prepare a list of the foods that you've mentioned above and my reactions to them. If I don't list a response, it's because I haven't noticed a direct reaction or I'm unsure.

Mary Beth's Problem Foods

Highly reactive:
salicylic acid - react to Pepto Bismol - not avoiding salicylates in general
lecithin - react to legumes - avoiding all lecithin
lettuce - react and avoiding
tapioca

Moderately reactive:
Wheat - avoiding
amaranth - avoiding
grapes - avoiding
oranges - react and avoiding
strawberries
cantaloupe - avoiding
apple - react and avoiding
blueberry - react and avoiding
apricot - avoiding
broccoli
green peppers - react and avoiding
sweet potato- react and avoiding
asparagus
tomato
cabbage - avoiding
cauliflower
beef
turkey
yeast
cashew - react and avoiding
pistachio - avoiding
almond - avoiding
lima bean - avoiding
sesame
cane sugar
lemon
paprika
black pepper
cayenne

Food Chemicals
capsaicin
solanine
FD&C blue #2
sorbic acid
MSG
sodium sulfite
saccharin

Gloria
You never know what you can do until you have to do it.
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mbeezie
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Post by mbeezie »

Hi Gloria,

Thanks for sharing your information. I am still testing foods and have added FODMAP restrictions to my diet. I'm going to give it a few more weeks (when I am at the end of week 6) and then give another update.

See my new GI tomorrow. I hope I like him - he specializes in IBDs.

Mary Beth
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