Hi All,
Apparently, mainstream medical researchers have finally decided to research the link between gluten sensitivity and ataxia. Evidently, they haven't quite come to grips with the fact that ataxia without celiac symptoms can be caused by gluten, because they choose to refer to it as "cerebellar ataxia", (IOW, they seem to be referring to it as "idiopathic" ataxia), but at least this is a start.
http://www.clinicaltrials.gov/ct2/show/ ... AUS&rank=3
Tex
Gluten Ataxia Finally Recognized By Mainstream Researchers
Moderators: Rosie, Jean, CAMary, moremuscle, JFR, Dee, xet, Peggy, Matthew, Gabes-Apg, grannyh, Gloria, Mars, starfire, Polly, Joefnh
Gluten Ataxia Finally Recognized By Mainstream Researchers
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Looks like the question is WHY the ataxia? Is it from another autoimmune reaction to synapsin I? If so, where is the cross-sensitivity with an environmental trigger located in the brain? Is it gluten itself, or something else, like an intermediary in the chain of events, as one possibility?
This looks like what seems to be the case in the osteoporosis findings posted earlier -- there's yet another autoimmune reaction to a specific protein going on in the bones that affects turnover.
I have an abnormal parathyroid, opposite hormone levels of said organ from what one would expect with historically low Vit D levels. Think I read somewhere that there is cross sensitivity from dairy casein to parathyroid tissue. Hope I"m right about the antigen, but if not, I know it was one of my lab-proven sensitivities. I'm sure there's yet another antigen-antibody reaction going on in my parathyroid, just as there was in my thyroid before it was removed.
I suspect to say gluten or these other foods we react to are the cause is really a short cut to something much more complicated. The gluten-small bowel autoimmune connection may be the simpliest to figure out, among this batch of somehow related conditions. I'm not sure I will ever know how to stop my advancing osteoporosis without having to resort to less desirable forms of treatment, at least not in my lifetime, early enough to prevent some pretty nasty things from happening, but perhaps the next generation will know much more.
Luce
This looks like what seems to be the case in the osteoporosis findings posted earlier -- there's yet another autoimmune reaction to a specific protein going on in the bones that affects turnover.
I have an abnormal parathyroid, opposite hormone levels of said organ from what one would expect with historically low Vit D levels. Think I read somewhere that there is cross sensitivity from dairy casein to parathyroid tissue. Hope I"m right about the antigen, but if not, I know it was one of my lab-proven sensitivities. I'm sure there's yet another antigen-antibody reaction going on in my parathyroid, just as there was in my thyroid before it was removed.
I suspect to say gluten or these other foods we react to are the cause is really a short cut to something much more complicated. The gluten-small bowel autoimmune connection may be the simpliest to figure out, among this batch of somehow related conditions. I'm not sure I will ever know how to stop my advancing osteoporosis without having to resort to less desirable forms of treatment, at least not in my lifetime, early enough to prevent some pretty nasty things from happening, but perhaps the next generation will know much more.
Luce
Luce,
I think the key issue has already been identified by Dr. Hadjivassiliou, last year.
According to the article about the 20% of celiacs who have the gene that predisposes to osteoporosis in celiacs, that specific issue is treatable, though the article does not say specifically how it can be treated. I got the impression that it might be a unique treatment, but if they're referring to the standard osteoporosis treatments, (Boniva, et. al.), then no practical treatment exists, as far as I'm concerned.
Tex
I think the key issue has already been identified by Dr. Hadjivassiliou, last year.
http://www.ncbi.nlm.nih.gov/pubmed/18825674INTERPRETATION: Antibodies against transglutaminase 6 can serve as a marker in addition to human leukocyte antigen type and detection of anti-gliadin and anti-transglutaminase 2 antibodies to identify a subgroup of patients with gluten sensitivity who may be at risk for development of neurological disease.
According to the article about the 20% of celiacs who have the gene that predisposes to osteoporosis in celiacs, that specific issue is treatable, though the article does not say specifically how it can be treated. I got the impression that it might be a unique treatment, but if they're referring to the standard osteoporosis treatments, (Boniva, et. al.), then no practical treatment exists, as far as I'm concerned.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.