Michael wrote:Are the also non-celiacs with gluten sensitivity that do not respond to calcium and vitamin D?
IMO, lack of response is not the problem with these individuals. The primary problem is the fact that vitamin D deficiency and magnesium deficiency are at epidemic proportions in the world today, and that predisposes us to certain problems (such as the development of IBDs, including celiac disease). In addition, IBDs deplete vitamin D levels, which compounds the problem. (You probably recall that references for that statement can be found in my book.) It's the combination of these issues that (IMO) predispose us to osteoporosis.
Michael wrote:And when we say do not respond, do we mean they will not be able to absorb either of these in the GI tract?
If I interpret the research article correctly, the study did not determine whether or not such patients can absorb vitamin D and/or calcium. Rather it determined that such patients did not respond to supplements. That implies that even if they absorbed the supplements, they were unable to utilize them to generate new bone tissue. This seems logical, if these patients were producing antibodies to osteoprotegerin, because remember that antibodies promote inflammation, and if inflamed tissue is chronically inflamed, then it cannot heal, because it is locked in the first stage of the healing process. IOW, before new bone tissue can be generated, the old tissue that is to be replaced, must be removed by the immune system. Until the debris is removed, new tissue cannot be regenerated, and bone density continues to decline.
Remember though, that research article only applies to the approximately 20 % of celiacs who produce antibodies against osteoprotegerin. 80 % of celiacs do not produce those antibodies, but they still suffer from osteoporosis (presumably at a less aggressive level, similar to the situation with non-celiac gluten sensitivity, because of the issues that I described in the first part of this post).
Tex
