Feel free to discuss any topic of general interest, so long as nothing you post here is likely to be interpreted as insulting, and/or inflammatory, nor clearly designed to provoke any individual or group. Please be considerate of others feelings, and they will be considerate of yours.
The finding that gut serotonin inhibits bone formation led the Columbia researchers to speculate that inhibiting serotonin synthesis could be an effective treatment for osteoporosis, Columbia's Gerard Karsenty, MD, PhD, tells WebMD.
"By pure serendipity, we came across an experimental drug that did just that," he says.
The oral drug, known as LP533401, was developed for the treatment of irritable bowel syndrome (IBS) and it has been tested in humans at high doses, he says.
The red is my highlight. I know nothing about LP533401 or if it has any effect on MC, but it has got my interest..
Harma wrote:Normally in mainstream medicine, this view is being ignored and threaded as nonsense (no scientific evidence).
Professor Plant is probably correct. There is also no scientific evidence that shows that drinking milk, (after childhood), prevents or reduces osteoporosis. Is there? I don't recall ever seeing any double-blind trials that showed that milk provides any significant osteoporosis benefit. The medical profession just assumes that milk helps to prevent osteoporosis, since it contains calcium, which is found in bones, of course. The mainstream medical researchers are the ones who have taken a simplistic approach, and they are wrong.
They have also incorrectly assumed that eating fat, (especially animal fat), causes human obesity, but proper research shows that eating fat does not cause obesity - excessive calorie intake, (usually from carbs), is the cause. Again, blaming fat is an overly simplistic outlook.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Yesterday, I went on a 2 hour walk over some hills on one of Hong Kong's islands. I felt pretty good, especially as the BM was firm in the morning and I could sleep on my left side for the first time since my rib fracture.
Enjoying my (new found) fitness, I played a game of Wii table tennis (amazing - you use the hand held control just like a real bat).....
Then, after one relatively forceful stroke.... Ouch! on one of my right ribs. Not a big pain to start, but I knew what it was - another small rib fracture.
Sorry for the downer, but I needed to tell you....
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Thanks, I would love it to just be a muscle pull. Is it difficult to distinguish between a small fracture and a muscle pull? I do not want yet another x-ray. The last one was only 3 or 4 weeks ago.
So far the pain reaction is very similar to last time (which the x-ray showed was a small fracture) i.e. increasing level of pain for a couple of days after (that is my current status), then about two weeks at the same level, followed by about 3 weeks of pain tapering off until things are back to normal..... The pain happens when I position myself in a particular way or with certain movements, so it is not all the time
I can handle this, but do not want it to get worse. I have an appointment with my new doctor on Thursday and will see what she says. I really do not like the sound of the bisphosphonates, but I may decide to take strontium.
I am going to spend some time on the healthboards website for Osteoporosis.
Yes, it is nearly impossible to distinguish between a rib fracture and an intercostal muscle strain. The symptoms are similar, and the treatment is the same (pain killers and rest). The only way to know for sure would be another xray. If you are concerned about too many xrays and are planning to go ahead with medication for osteoporosis anyway, you could probably skip the xray.
Are you feeling any better?
Love,
Polly
Blessed are they who can laugh at themselves, for they shall never cease to be amused.
Hello Ant, I am sorry to hear about your rib fracture or muscle pull. The first part of your message sounded so great, go out for a long walk, that your earlier fracture is healing well and the information on you bowel movements ( no idea why we call ourselves the potty people). I hope you will get well soon.
Thanks so much for your support and information. I am ok today, same level of pain. Would I be right to assume that if it is a strain it will go away quicker than a fracture?
Harma, we are indeed totally, completely,outrageously,ridiculously,wonderfully ..... POTTY
my poor old computer at home doesnt like heat and humidity so i havent been able to use it much..... bring on some cooler weather.......
THank goodness the fun police here at work havent blocked this website! When i need a break from contract docs and temperamental engineers, is when i log in and view the posts etc
Gabes Ryan
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
Ant, I came across this scientific article talking about the importance of Vit C, Vit B6 and the amino acid proline in osteoporosis. The entire article is available at the url below. It's a bit hard to read, but it makes sense that in order to build bone, you need all of the building blocks, not just calcium and Vit D. And with MC, we have deficiencies of the B vitamins in particular. One thing about the paper is that the supplimentation with Vit D was pretty whimpy, 500 U per day.
But it's in the category of "can't hurt, might help" and I thought I'd throw it out here.
Enhancement of Calcium/Vitamin D Supplement Efficacy by Administering Concomitantly Three Key Nutrients Essential to Bone Collagen Matrix for the Treatment of Osteopenia in Middle-Aged Women: A One-Year Follow-Up
It appears that the CB6Pro (Vitamin C, Vitamin B6 and the amino acid proline) preparation enhanced the calcium/vitamin D supplement efficacy in building new bone and this could explain the success of their combination in halting bone loss.
The present follow-up study on middle-aged osteopenic patients was aimed to treat their bone loss using a nutritive preparation containing three nutrients essential in collagen formation, administered in pharmacologic doses for one-year, in conjunction with a conventional calcium/vitamin D supplement, as an early preventive measure against osteoporosis. This new approach is based on the hypothesis that improvement and stabilization of the collagenous bone matrix structure will enhance the efficacy of calcium/vitamin D supplementation conventionally prescribed to counteract bone mineral loss.
Bone matrix is a complex, highly mineralized tissue with a structural framework composed primarily of collagen [12]. Several nutritional factors other than calcium are involved, but their influence on BMD and biomarkers of bone turnover, particularly the new one (type I collagen helical peptide), is still largely unknown. An early correlation study showed that several nutrients were related to bone loss in women (aged between 35–65 years) [13]. Vitamins C (ascorbic acid) and B6 are vital components in the biology of bone cells and resultant bone mass. Vitamin C is the required coenzyme in the hydroxylation of proline and lysine during collagen synthesis in osteoblasts (bone cells) whereas vitamin B6 is involved as coenzyme in the assembly process of collagen (aldehyde cross-link formation) in the extracellular matrix. Masse et al.’s biomechanical study demonstrated the importance of this extracellular process for the strength of bone using a vitamin B6-deficient animal model [14]. The only clinical study on this vitamin in relation to bone was reported by Reynolds et al. [15] who showed that half of their hip fracture patients were vitamin B6-deficient.
Our greatest weakness lies in giving up. The most certain way to succeed is always to try just one more time………Thomas Edison
Thanks for the link. I agree that vit deficiancies are a big (possible key factor). I am letting my new doctor IV lots of vitamins and minerals into me to build back my count. Unfortunately this may be a bit of 'closing the stable door after the horse has bolted'. But it may stop other horses from leaving the stable and, as you say, "can't hurt might help". I am reading the Reiner Bartl book Harma reccoed and it supports a lot the vit d, b, c arguments.
no idea why we call ourselves the potty people). I hope you will get well soon. 
. I'm glad you had a wonderful weekend with TK.