Hi All,
This project involves a double-blind, randomized, parallel-group, 6-week study comparing the effects of gluten rich versus gluten free diets in diarrhea or diarrhea predominant IBS patients. Patients will receive either a 4-week gluten-free diet, or a 4-week gluten-rich diet, and they will each keep a daily bowel pattern diary throughout the study.
This could be the start of something Big, if this study is carried out with complete honesty, (IOW, this could lead to the validation of the existence of NCGS, (Non-Celiac Gluten Sensitivity).
http://www.clinicaltrials.gov/ct2/show/ ... AUS&rank=2
Tex
The Mayo Clinic Is Studying Gluten Intolerance With IBS
Moderators: Rosie, Jean, CAMary, moremuscle, JFR, Dee, xet, Peggy, Matthew, Gabes-Apg, grannyh, Gloria, Mars, starfire, Polly, Joefnh
The Mayo Clinic Is Studying Gluten Intolerance With IBS
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Hot Damn!!! I love that. In spite of the fact that they probably killed my GF and altered my fathers life, they still are a highly respected source. And- they are the ones who own the test that so many of us have tested negative for, only to test positive via Enterolab. Maybe they see the writing on the wall, maybe the drug companies no longer rule "the world of research in the US" now that we have supposedly passed healthcare legislation here.
Minnesota is full of Scandinavians-shouldn't be hard to replicate the research already done in Norway, Sweden and Finland.
Minnesota is full of Scandinavians-shouldn't be hard to replicate the research already done in Norway, Sweden and Finland.
Resolved MC symptoms successfully w/L-Glutamine, Probiotics and Vitamins, GF since 8/'09. DX w/MC 10/'09.
yes this could be the start of something great, or just another break down. Six weeks is very short, it is not uncommon that it takes a bit longer to see benefits of a gluten free diet. Also can they be sure, that the people that eat gluten free actually do it 100%. If it is not explained well enough there always will be some thinking, well a little (only one cookie) probably won't hurt. I sometimes read or speak to people who eat a low gluten diet. My idea this is due to a lack of knowledge how a gluten intolerance work, only a crumble of gluten can induce a reaction.
And like Ant is saying, if they keep on using diary (if it was only for the lactose).
But yes at least it is a start.
And like Ant is saying, if they keep on using diary (if it was only for the lactose).
But yes at least it is a start.
Ant,
You're right, but you have to remember that a lot of these celiac docs seem to think that a few days to a week should be enough time on the GF diet to bring remission, and a week or so later, the intestines should be healed.
Since the trial only considers gluten sensitivity, other food sensitivities are off their radar, and they probably incorrectly just assume that they won't matter.
Harma,
Using the honor system is the biggest weakness with this trial, so all we can do is hope that if some of them cheat on the diet, they will be honest and report it in the diary. The biggest risk is that some of them may ingest gluten, without even realizing it, and they obviously won't report it, if they aren't even aware of it. Because of that, you can bet that the results will under rate the benefits of the diet.
Regardless of the flaws in the study, at least it's a start, and it's an admission by the doctors at the Mayo Clinic, that gluten-sensitivity may be involved in non-celiac digestive system issues, and that's a Huge step, for those guys.
Tex
You're right, but you have to remember that a lot of these celiac docs seem to think that a few days to a week should be enough time on the GF diet to bring remission, and a week or so later, the intestines should be healed.
Since the trial only considers gluten sensitivity, other food sensitivities are off their radar, and they probably incorrectly just assume that they won't matter. Harma,
Using the honor system is the biggest weakness with this trial, so all we can do is hope that if some of them cheat on the diet, they will be honest and report it in the diary. The biggest risk is that some of them may ingest gluten, without even realizing it, and they obviously won't report it, if they aren't even aware of it. Because of that, you can bet that the results will under rate the benefits of the diet.
Regardless of the flaws in the study, at least it's a start, and it's an admission by the doctors at the Mayo Clinic, that gluten-sensitivity may be involved in non-celiac digestive system issues, and that's a Huge step, for those guys.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
I agree with you tex it is a HUGE step for mainstream medicine. What I have read (quite often) on a Dutch celiac message board, the reaction of GI doc's if patients don't have Celiac but do find relieve in gluten free food "gluten free food is easier to digest", gluten containing food is heavy, gluten free food is considered light. Also a lot of people there give this reaction if a non-celiac report good results with a gluten free diet. I think this is BS. I still have forgotten how much pain of did get of gluten free food (the stuff of the gluten free shell in the Supermarket) after starting eating gluten free
Ant,
That's my biggest fear, too, I have to admit, but I'm in an optimistic mood today, so here's hoping for the best.
Tex
That's my biggest fear, too, I have to admit, but I'm in an optimistic mood today, so here's hoping for the best.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
What they probably don't realize when they make that statement, is that it is totally true, and it is an admission that the human digestive system cannot digest the peptides that cause a celiac-type reaction. The fact is, no one can digest those peptides, but for most people, they just pass through the digestive system without any noticeable affect. For those of us who are sensitive to them, our immune system detects them, and triggers an autoimmune reaction.Harma wrote:"gluten free food is easier to digest"
The main point of interest, though, is the fact that no one can digest those peptides, so even for people who do not react to them now, those peptides may be "an accident waiting to happen", in the future.
Also, when they make that statement, they probably think that those of us who react adversely to gluten, have either weak digestive systems, or weak immune systems. That is totally wrong. Our digestive system is just as effective as everyone else's. The problem is that our immune system is better developed than theirs, and it is capable of detecting the toxic nature of those peptides that we react to. People who are not gluten-sensitive, are able to eat those toxic peptides, simply because their immune systems are naive, and incapable of detecting the toxic nature of the peptides.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
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Gabes-Apg
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mmmm bad memories coming back.. 12 months ago i moved house and was establishing myself with a new GP. She wouldnt believe the IBS diagnosis that i had managed with diet (mostly GF/YF/LF) for the past 10 years.
I said to her i know that i am not celiac but my body is 200% happier if i dont have gluten/yeast and lactose. She openly said that she could not accept that reasoning!
She wanted to do the celiac test, so i ate gluten for 2 weeks to have the blood test. it took me over a week to recover (i had to have two days of work due to migraines, cramping pains, interupted sleep, lethargy)
after that i change doctors!
I said to her i know that i am not celiac but my body is 200% happier if i dont have gluten/yeast and lactose. She openly said that she could not accept that reasoning!
She wanted to do the celiac test, so i ate gluten for 2 weeks to have the blood test. it took me over a week to recover (i had to have two days of work due to migraines, cramping pains, interupted sleep, lethargy)
after that i change doctors!
Gabes Ryan
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama