A) Gluten Sensitivity Stool and Gene Panel Complete *Best test/best value
Fecal Anti-gliadin IgA Greater than 500 Units (Normal Range is less than 10 Units)
Fecal Anti-tissue Transglutaminase IgA 24 Units (Normal Range is less than 10 Units)
Quantitative Microscopic Fecal Fat Score Less than 300 Units (Normal Range is less than 300 Units)
Fecal Anti-casein (cow’s milk) IgA 19 Units (Normal Range is less than 10 Units)
HLA-DQB1 Molecular analysis, Allele 1 0201
HLA-DQB1 Molecular analysis, Allele 2 0501
Serologic equivalent: HLA-DQ 2,1 (Subtype 2,5)
Interpretation of Fecal Anti-gliadin IgA: Intestinal antigliadin IgA antibody was elevated, indicating that you have active dietary gluten sensitivity. For optimal health, resolution of symptoms (if you have them), and prevention of small intestinal damage and malnutrition, osteoporosis, and damage to other tissues (like nerves, brain, joints, muscles, thyroid, pancreas, other glands, skin, liver, spleen, among others), it is recommended that you follow a strict and permanent gluten free diet. As gluten sensitivity is a genetic syndrome, you may want to have your relatives screened as well.
Interpretation of Fecal Anti-tissue Transglutaminase IgA: You have an autoimmune reaction to the human enzyme tissue transglutaminase, secondary to dietary gluten sensitivity.
Interpretation of Quantitative Microscopic Fecal Fat Score: Provided that dietary fat is being ingested, a fecal fat score less than 300 indicates there is no malabsorbed dietary fat in stool indicating that digestion and absorption of nutrients is currently normal.
Interpretation of Fecal Anti-casein (cow’s milk) IgA: Levels of fecal IgA antibody to a food antigen greater than or equal to 10 are indicative of an immune reaction, and hence immunologic “sensitivity” to that food. For any elevated fecal antibody level, it is recommended to remove that food from your diet. Values less than 10 indicate there currently is minimal or no reaction to that food and hence, no direct evidence of food sensitivity to that specific food. However, because 1 in 500 people cannot make IgA at all, and rarely, some people can still have clinically significant reactions to a food antigen despite the lack of a significant antibody reaction (because the reactions primarily involve T cells), if you have an immune syndrome or symptoms associated with food sensitivity, it is recommended that you try a strict removal of suspect foods from your diet for up to 12 months despite a negative test.
Interpretation Of HLA-DQ Testing: HLA-DQB1 gene analysis reveals that you have one of the main genes that predisposes to gluten sensitivity and celiac sprue, HLA-DQB1*0201 or HLA-DQB1*0302. Each of your offspring has a 50% chance of receiving this gene from you, and at least one of your parents passed it to you. You also have a non-celiac gene predisposing to gluten sensitivity (any DQ1, DQ2 not by HLA-DQB1*0201, or DQ3 not by HLA-DQB1*0302). Having one celiac gene and one gluten sensitive gene, means that each of your parents, and all of your children (if you have them) will possess at least one copy of a gluten sensitive gene. Having two copies also means there is an even stronger predisposition to gluten sensitivity than having one gene and the resultant immunologic gluten sensitivity or celiac disease may be more severe.
You may post these TEX..
Romanita
Enterolab results.....
Moderators: Rosie, Stanz, Jean, CAMary, moremuscle, JFR, Dee, xet, Peggy, Matthew, Gabes-Apg, grannyh, Gloria, Mars, starfire, Polly, Joefnh
Enterolab results.....
I can do ALL THINGS through Christ who strengthens me!!!!
Hi Linda,
You must have some real mixed feelings here in your much anticipated results. Your Fecal Anti-gliadin IgA score is very high, no wonder you have been so miserable. I'm another double DQB1, there are many of us here.
I'm sorry about the results on the dairy, I'm sure this wasn't what you wanted to see. At least you know now, and there is a great deal of relief in just knowing where to go from here.
Connie
You must have some real mixed feelings here in your much anticipated results. Your Fecal Anti-gliadin IgA score is very high, no wonder you have been so miserable. I'm another double DQB1, there are many of us here.
I'm sorry about the results on the dairy, I'm sure this wasn't what you wanted to see. At least you know now, and there is a great deal of relief in just knowing where to go from here.
Connie
Resolved MC symptoms successfully w/L-Glutamine, Probiotics and Vitamins, GF since 8/'09. DX w/MC 10/'09.
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Gabes-Apg
- Emperor Penguin
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bugger bugger bugger........ lactose free milk wont work, you willl have to consider eliminating all dairy....
fantastic that you have the results and you can now plan your meals and get control
have a great day (or night)
fantastic that you have the results and you can now plan your meals and get control
have a great day (or night)
Gabes Ryan
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
Romanita,
Your gluten-sensitivity test result is out of range
- more evidence that you are probably a celiac, (and you do have the most common celiac gene). Notice how much more sensitive the stool tests are, compared with the blood tests. The stool test values have to be out of range, or at least near the upper limits, before the blood tests will detect a positive anti-gliadin antibody result.
I couldn't help but notice that your genes are an exact match with mine, and I've always suspected that I'm a celiac, (though my GI doc failed to test me for CD). The only other member here with the same genes, is Courtney, and she was diagnosed with celiac disease, shortly before she was diagnosed with MC.
Thanks - I've added your results to our lists.
Tex
Your gluten-sensitivity test result is out of range
- more evidence that you are probably a celiac, (and you do have the most common celiac gene). Notice how much more sensitive the stool tests are, compared with the blood tests. The stool test values have to be out of range, or at least near the upper limits, before the blood tests will detect a positive anti-gliadin antibody result.I couldn't help but notice that your genes are an exact match with mine, and I've always suspected that I'm a celiac, (though my GI doc failed to test me for CD). The only other member here with the same genes, is Courtney, and she was diagnosed with celiac disease, shortly before she was diagnosed with MC.
Thanks - I've added your results to our lists.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Tex,
So according to this I have one celiac and one non-celiac gluten sensitivity gene from each parent, and my daughters each have one of these genes. So should I have them tested or just go GF with them as well? They could be gluten sensitive or just carriers of the gene, right? I already suspect that my oldest daughter is casein sensitive, and she is coming to terms with no dairy. I really believe that I my father must have been celiac, because my mother said he always had trouble with foods, and (like my oldest) had what sounds to me like eczema (cracking skin on ears, oozing, like my daughter). I didn't know him well, but my mom said he saw a "specialist" for that. Don't know what kind of "specialist" though.
What to do????
Romanita
So according to this I have one celiac and one non-celiac gluten sensitivity gene from each parent, and my daughters each have one of these genes. So should I have them tested or just go GF with them as well? They could be gluten sensitive or just carriers of the gene, right? I already suspect that my oldest daughter is casein sensitive, and she is coming to terms with no dairy. I really believe that I my father must have been celiac, because my mother said he always had trouble with foods, and (like my oldest) had what sounds to me like eczema (cracking skin on ears, oozing, like my daughter). I didn't know him well, but my mom said he saw a "specialist" for that. Don't know what kind of "specialist" though.
What to do????
Romanita
I can do ALL THINGS through Christ who strengthens me!!!!
Romanita,
Focus on YOU first and getting your symptoms under control. I have the oozing ears also, I can count on it like clockwork if I allow myself to feel stress. It takes much practice and mind control not to let stress get you.
I don't imagine any specialist your father may have seen as having any valuable information, frankly.
Unless your daughters are tested they won't know, just as none of us did, but IMO, the sooner the better to eliminate doubt. The genetic results aren't going to change and the sooner they know, they less body damage they will have.
Connie
Focus on YOU first and getting your symptoms under control. I have the oozing ears also, I can count on it like clockwork if I allow myself to feel stress. It takes much practice and mind control not to let stress get you.
I don't imagine any specialist your father may have seen as having any valuable information, frankly.
Unless your daughters are tested they won't know, just as none of us did, but IMO, the sooner the better to eliminate doubt. The genetic results aren't going to change and the sooner they know, they less body damage they will have.
Connie
Resolved MC symptoms successfully w/L-Glutamine, Probiotics and Vitamins, GF since 8/'09. DX w/MC 10/'09.
Romanita,
Yes, each of your daughters has a 50-50 chance of inheriting a celiac gene from you. Of course, having the gene doesn't guarantee that the disease will develop - something has to trigger the gene, in order to activate the disease.
Most GI docs become upset at the mere mention of someone adopting the GF diet, without an official celiac diagnosis, but of course, we all have to decide what is best for us and our kids. I really don't feel qualified to advise you, though, about whether or not they should be tested at this point. If you can spare the money, it's always better to know, than to guess, but unless the disease is triggered someday, the information is irrelevant, I suppose.
How does your husband feel about this? It's certainly possible that he might be carrying a celiac gene, also, but it was never triggered.
Tex
Yes, each of your daughters has a 50-50 chance of inheriting a celiac gene from you. Of course, having the gene doesn't guarantee that the disease will develop - something has to trigger the gene, in order to activate the disease.
Most GI docs become upset at the mere mention of someone adopting the GF diet, without an official celiac diagnosis, but of course, we all have to decide what is best for us and our kids. I really don't feel qualified to advise you, though, about whether or not they should be tested at this point. If you can spare the money, it's always better to know, than to guess, but unless the disease is triggered someday, the information is irrelevant, I suppose.
How does your husband feel about this? It's certainly possible that he might be carrying a celiac gene, also, but it was never triggered.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Romanita,
I think it's a good idea to test your children. I did enterolab testing on my son and he was a DQ 2,1 so he also has a celiac gene, which he did not get from me. The point is, I never would have guesed he would get a celiac gene from my husband since I am the symptomatic one. So you never really know. If they have 2 celiac genes then chances are even higher. I regret not getting the blood test on my son before he went GF.
Mary Beth
I think it's a good idea to test your children. I did enterolab testing on my son and he was a DQ 2,1 so he also has a celiac gene, which he did not get from me. The point is, I never would have guesed he would get a celiac gene from my husband since I am the symptomatic one. So you never really know. If they have 2 celiac genes then chances are even higher. I regret not getting the blood test on my son before he went GF.
Mary Beth
Dear Romanita,
I believe MC, Celiac, UC and Chrons, are just the tip of the iceberg as far as these food intolerances are concerned. There are numerous other conditions at various degrees of seriousness from MS to skin irritation that could be traced back to these food intolerances.
If you can afford it if I where you I would test your kids.
All the best, Ant
I believe MC, Celiac, UC and Chrons, are just the tip of the iceberg as far as these food intolerances are concerned. There are numerous other conditions at various degrees of seriousness from MS to skin irritation that could be traced back to these food intolerances.
If you can afford it if I where you I would test your kids.
All the best, Ant
My husband definitely wants me to let my GI know about my gene test results when I get my biopsy results to see what they say. I definitely think that the earlier we know the better it will be as far as getting them use to eating GF if they have to. I am eliminating dairy on my oldest daughter to see if that helps her eczema. With meds it clears up for a few days at best before returning. I am also thinking about having her tested for food allergies (before she goes completely DF)
Til next time!
Romanita
Til next time!
Romanita
I can do ALL THINGS through Christ who strengthens me!!!!
I don't think she needs to be eating dairy for an allergy test. There are lots of great dairy free products to replace kids favorites. The only problem is cheese - you can buy a casein free cheese (Follow Your Heart brand) but it is made with soy, which is equally detrimental IMHO. Let me know if you need ideas for GF/DF products for kids - after a year of doing this I think we got it down.
Mary Beth
Mary Beth
Romanita, welcome to our group and glad you have received your results. I also was tested high on the Anti-gliadin IgA; 402 and have been GF/DF for 5 mo. and SF/EF for 4 mo. Patience and knowledge is the key to helping yourself and also your family adopt to the lifestyle that will be required. Connie is right, take care of yourself first and the way you eat will most likely fall in line with the rest of your family. My daughter who is an adult and mentally challenged fights a chronic candida problem and our lifestyle change has helped her immensely. I've added this group to my morning prayers and rosary.........how can we lose! Love Ginny
Romanita,
In case your GI doc does not trust Enterolab's results, (which is true for many GI docs), point out to him that Enterolab does not do the gene tests in-house - they send those out to The Red Cross. IOW, The Red Cross does the actual genetic testing for Enterolab. All the other tests, (except for the gene tests), are done at the Enterolab facilities, in Dallas.
Tex
In case your GI doc does not trust Enterolab's results, (which is true for many GI docs), point out to him that Enterolab does not do the gene tests in-house - they send those out to The Red Cross. IOW, The Red Cross does the actual genetic testing for Enterolab. All the other tests, (except for the gene tests), are done at the Enterolab facilities, in Dallas.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.