b12
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b12
Hi all, havent been on in a while. Diangosed with LC in 2006. Been doing ok on Asacol 4X a day Colestipol for the diarrhea. I have been B12 deficient. Doing injections once a month. The levels have been going up but now I just had my levels checked and they are lower than they were in January. They are still in the normal range but why lower even with the injections?? Can anyone explain this. Thank you.
LC diagnosed 10/06
Vitamin B12 deficient
Vitamin B12 deficient
Hi Deb,
Sorry to hear that the injections aren't working as they should. I don't know how to explain that, since you should be able to absorb the injections, even if your stomach is not secreting intrinsic factor. Did your doctor check serum levels, or tissue levels? Tissue levels are supposed to be a more accurate way to access B-12 storage levels. If you happen to be taking the diabetes medication, metformin, it can interfere with B12 dietary absorption, but again, that shouldn't prevent the injected form from working. Supposedly, the second-best way to acquire B-12, (by means of a supplement), is by intra-nasal application. IOW, it's possible to buy a B-12 gel, OTC, which can be applied inside the nasal passageways. I don't know the details on how that works, though - maybe your doctor would know.
According to research, it is claimed that when given in oral doses in the 1 to 2 mg range, daily, B-12 can be absorbed in a pathway that does not require an intact ileum, or intrinsic factor. Supposedly, oral treatment with 2 mg per day was as effective as monthly 1 mg injections, in tests.
http://bloodjournal.hematologylibrary.o ... /92/4/1191
Tex
Sorry to hear that the injections aren't working as they should. I don't know how to explain that, since you should be able to absorb the injections, even if your stomach is not secreting intrinsic factor. Did your doctor check serum levels, or tissue levels? Tissue levels are supposed to be a more accurate way to access B-12 storage levels. If you happen to be taking the diabetes medication, metformin, it can interfere with B12 dietary absorption, but again, that shouldn't prevent the injected form from working. Supposedly, the second-best way to acquire B-12, (by means of a supplement), is by intra-nasal application. IOW, it's possible to buy a B-12 gel, OTC, which can be applied inside the nasal passageways. I don't know the details on how that works, though - maybe your doctor would know.
According to research, it is claimed that when given in oral doses in the 1 to 2 mg range, daily, B-12 can be absorbed in a pathway that does not require an intact ileum, or intrinsic factor. Supposedly, oral treatment with 2 mg per day was as effective as monthly 1 mg injections, in tests.
In cobalamin deficiency, 2 mg of cyanocobalamin administered orally on a daily basis was as effective as 1 mg administered intramuscularly on a monthly basis and may be superior.
http://bloodjournal.hematologylibrary.o ... /92/4/1191
http://fampra.oxfordjournals.org/cgi/co ... t/23/3/279Conclusions. The evidence derived from these limited studies suggests that 2000 µg doses of oral vitamin B12 daily and 1000 µg doses initially daily and thereafter weekly and then monthly may be as effective as intramuscular administration in obtaining short-term haematological and neurological responses in vitamin B12-deficient patients.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.