Hi everyone. Well- I am finally all over the sulphasalazine side effects- ugg- not pleasant. After the side effects disappeared, the normal BMs continued for another week- but then (now) I'm having a CC flare up. I have to say though- the flare is preferable to the sulphasalazine side effects. Anyway, I've ageed to another colonoscopy ( as I've had CC for 10 years now), and I will discuss other med options with my NEW doctor when I feel ready. In the meantime, I'm wondering:
Maybe someone can tell me ( Ant, Tex, Joe, Joann, someone - there's so many of you lovely sensible and knowledgeable people here): If Pepto Bismol is used for CC- how does that theory correspond with the ' no aspirin' relationship to CC ( isn't Pepto B a salicylic)? Just wondering, because I think I'd like to try it, and would like to know as much as I can when I do discuss it with my doctor. Also- does it have anti inflammatory action on the colon at all?
Hope you are all well and doing ok. Thankyou for your kind support. Mia
recovered from my sulphasalazine side effects
Moderators: Rosie, Jean, CAMary, moremuscle, JFR, Dee, xet, Peggy, Matthew, Gabes-Apg, grannyh, Gloria, Mars, starfire, Polly, Joefnh
Mia,
That's definitely good news, that your reaction to the medication has settled down.
Technically, I suppose you could classify Pepto-Bismol as an NSAID, since it does not contain a corticosteroid, but it does have anti-inflamatory properties. However, it is very dissimilar to the class of drugs typically referred to as NSAIDs. For that matter, all of the 5-ASA medications, (including Asacol, Colozal, Lialda, Pentasa, etc), are also based on salicylates. From the sulfasalazine that you used, your body created mesalamine, (plus sulfapyridine), and mesalamine is simply a generic form of all of the brand name products listed in the last sentence, so that means that most of the drugs used to treat MC, are based on salicylates, and technically, they could probably be classified as NSAIDs, (though they are generally not considered to be NSAIDs). Besides the soothing, coating action of the bismuth subsalicylate, and it's ability to suppress intestinal inflammation, Pepto-Bismol actually has some degree of antibiotic action, also. A certain percentage of people do react adversely to it, so it does not work for everyone. For those who can tolerate it though, it usually has a high rate of effectiveness.
If you decide to try it, I hope it works well for you.
Also, please let us know how your new doctor checks out.
Tex
That's definitely good news, that your reaction to the medication has settled down.
That's a very good question, and I'm afraid that I don't know enough about the chemistry involved, to be able to provide a good answer. The fact of the matter is that no one knows why any of the anti-inflamatories suppress inflammation, in the first place, whether steroidal, or non-steroidal. They only know that they work. The specific mechanism involved, remains a mystery.Mia wrote:If Pepto Bismol is used for CC- how does that theory correspond with the ' no aspirin' relationship to CC ( isn't Pepto B a salicylic)?
Technically, I suppose you could classify Pepto-Bismol as an NSAID, since it does not contain a corticosteroid, but it does have anti-inflamatory properties. However, it is very dissimilar to the class of drugs typically referred to as NSAIDs. For that matter, all of the 5-ASA medications, (including Asacol, Colozal, Lialda, Pentasa, etc), are also based on salicylates. From the sulfasalazine that you used, your body created mesalamine, (plus sulfapyridine), and mesalamine is simply a generic form of all of the brand name products listed in the last sentence, so that means that most of the drugs used to treat MC, are based on salicylates, and technically, they could probably be classified as NSAIDs, (though they are generally not considered to be NSAIDs). Besides the soothing, coating action of the bismuth subsalicylate, and it's ability to suppress intestinal inflammation, Pepto-Bismol actually has some degree of antibiotic action, also. A certain percentage of people do react adversely to it, so it does not work for everyone. For those who can tolerate it though, it usually has a high rate of effectiveness.
If you decide to try it, I hope it works well for you.
Also, please let us know how your new doctor checks out.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
