Gluten Intolerance in Patients With Diarrhea Predominant IBS

[tex]

This appears to be an interesting trial.

The study design is a double-blind, randomized, controlled, parallel-group, 6-week study comparing the effects of gluten rich versus gluten free diets in diarrhea or diarrhea predominant IBS patients. All participants will keep a daily bowel pattern diary throughout the study. All participants will have negative serum tissue transglutaminase (TTg) assay, and anti-endomysial antibody test, if TTg is positive or equivocal. All participants will have the following studies performed both before and after the 4-week dietary intervention:

1. Stool samples to check markers of inflammation such as fecal calprotectin.
2. Blood samples to check markers of inflammation and for genetic testing.
3. After ingestion of the mannitol, lactulose and sucralose sugars, urine samples to indirectly measure small intestinal and colonic permeability.
4. After sedation, upper gastrointestinal endoscopy and flexible sigmoidoscopy to obtain 6 mucosal biopsies from the small bowel and sigmoid colon for immunohistochemical analysis.
5. Scintigraphy to measure gastrointestinal transit.

http://www.clinicaltrials.gov/ct2/show/ ... AUS&rank=9

Tex

[Gloria]

4. After sedation, upper gastrointestinal endoscopy and flexible sigmoidoscopy to obtain 6 mucosal biopsies from the small bowel and sigmoid colon for immunohistochemical analysis.

I hope they also look for MC.

This does sound like an interesting trial because they will be looking for markers of inflammation in the blood and stool. If they were simply looking for a reduction in D after abstaining from gluten, the trial would be skewed at the outset because of potential multiple intolerances.

Gloria

[MaggieRedwings]

Actually a study that seems to be in line with actual research and could show results that would be beneficial to patients.

WoHoo!

Maggie