Sero-negative celiac disease

[collagastritis84]

NTRODUCTION: We report a case of sero-negative celiac disease in Pakistan. CASE PRESENTATION: A 20-year-old female presented with papulovesicular rash for 15 years, diarrhea for 8 years, spasms of hands and twitching of face for 4-5 months. She had mild anemia, low vitamin-D3 and serum calcium. On exclusion of other causes of malabsorption, anti-tissue transglutaminase antibodies (immunoglobulin-A & immunoglobulin-G), anti-endomysial antibodies, total immunoglobulin-A levels and skin biopsy were performed, which were normal. Intestinal biopsy revealed subtotal villous atrophy. Patient was prescribed gluten-free diet, to which she responded with alleviation of symptoms. CONCLUSION: Negative serology should not rule out celiac disease; intestinal biopsy should be performed if there is strong clinical suspicion

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[Linda in BC]

Hope that article is published where it can be read by lots of GI doctors.
Thanks, ibrown.
Linda

[tcorbett]

Also, if the celiac is negative, they should check for gluten intolerance - different test - would explain why the GF diet worked! As well as a biospy too as stated above. T