MICROSCOPIC COLITIS SUPPORT

Go the 4th month or even longer for weaning off of Budesonide. I took it for almost a full year tapering off ever so slowly.......like I was down to 1 tablet every 3-4 days for awhile and eventually went off of it. I felt really good when I was on it and noticed a lot of things (like aches and pains and things like that) when I weaned myself off. That all eventually goes away when it's out of your system.

I was reading through some old posts and came across this:

My thoughts on antihistamines are: If you need 'em, use 'um. If you don't need 'em, don't take 'em.

Tex

( No disrespect, It kinda contradicts your earlier post to my "tapering of Budesonide" question? See Thread for questions and replies.)

In my opinion, the mechanism of action is this:

*Antihistamines inhibit seretonin uptake. About 90 % of our seretonin is located in our enterochromaffin (EC) cells in our intestinal epithelia. Seretonin released from EC cells regulates motility in the gut (in the brain seretonin affects mood, etc.). Obviously, motility regulation is one of the primary problems with any type of colitis.

Corticosteroids work by suppressing mast cell numbers and activity. Weaning off a corticosteroid results in a rebound of mast cell numbers and activity, which tends to promote increased motility. So weaning too fast causes mast cell numbers to overshoot their normal population and activity level, resulting in diarrhea in many cases. So I think they work by using the inhibition of serotonin uptake to suppress motility, thereby limiting the risk of increased motility (and diarrhea).

Tex

It doesnt contradict earlier post, not everyone here takes budenside/steroids/coricorsteroid.
the statement that tex made above is in the context of when you are 'weaning off corticosteroid'

digestion is complex and it changes, what we do now may not be what we need to do in 6 months time.
another layer of complexity to this is that we actually need small amounts of histamine for good digestion. that is why tex makes the statement if you need them, use them, if you dont need them dont take them.

taking anti-histamines constantly for years is not ideal for long term wellness and optimised digestion.

my other thought on this topic

I resolved life long allergy/histamine issues via fixing my magnesium and B6 deficiencies (both are key for moderating histamine/mast cells)
what we have observed over time, is the importance that when taking budenside/corticosteriods people need to be increasing magnesium and active B's so that when they do start to taper the body has the right nutrients to help balance mast cell and adrenal changes that are occuring.

Thanks Gabes. I have to apologize for being kinda dense, 'cause I don't see any contradiction. One should never take any medication if it's not needed. If your remission is sorta fragile, and you feel that you need/want a little insurance when weaning off budesonide, then take an antihistamine. It may help. If you feel secure without it, then don't take an antihistamine.

Typing is not as much fun since the stroke, so I may not always include all the caveats and other details when I respond to a question that's been asked many times before.

Tex

Typing is not as much fun since the stroke, so I may not always include all the caveats and other details when I respond to a question that's been asked many times before.

agreed... (even those of us that have not had stroke struggle to include all relevant side info/supplementary info/alternatives etc) the healing journey in MC world so complex that the context of statements we make /information we provide has various meanings depending on the thread topic/individual circumstances being replied to!!