I happened to be looking through my husband’s Nov. 9th issue of Chemical and Engineering News. An article on a new computational method to find new targets of old drugs caught my eye. This method uses a computer algorithm on a database to identify drug targets based on how much a compound looks like the normal ligand of the drug. They discovered thousands of unanticipated interactions and selected 30 of them to experimentally test, confirming 23 of the 30 interactions.
One of the examples was Prozac, an SSRI drug. They discovered that it also binds the totally unrelated beta 1 adrenergic receptor, a G-protein-coupled-receptor that usually binds such compounds as epinephrine and nonepinephrine. I found it interesting that this receptor is involved with potassium secretion in the colon, so may play a role in the watery diarrhea that is characteristic of MC. Of course this all can get very complicated, and the mechanism may be entirely different, but it does provide a possible explanation.
This article brings home yet again that drugs can have very different side effects in the body, and very little is truly known.
Rosie
Possible way that SSRI's can trigger MC
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Possible way that SSRI's can trigger MC
Our greatest weakness lies in giving up. The most certain way to succeed is always to try just one more time………Thomas Edison
Interesting.
Tex
Yep, I would assume that drug trials, for the most part, only meet the requirements imposed by FDA, and just as any prudent taxpayer, in an interview with an IRS agent, concerning a question about a deduction on a return, would never volunteer any information not asked for, surely the drug companies don't make a habit of volunteering any information, either. They just hope that nothing bad turns up later.Rosie wrote:This article brings home yet again that drugs can have very different side effects in the body, and very little is truly known.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Well I'll go to my grave believing that statin drugs caused me to have a flare-up.
So much so that if another Doc tries to get me to try them, I shall refuse. I am tired of pill-pushing Docs and Big Pharma trying to tell us what is best for us, well me. I'm listening to my body.
I am getting old and cranky and standing up for myself.
Deb
So much so that if another Doc tries to get me to try them, I shall refuse. I am tired of pill-pushing Docs and Big Pharma trying to tell us what is best for us, well me. I'm listening to my body.
I am getting old and cranky and standing up for myself.
Deb
Hypothyroid 06/01
LC 12/06
Dwell on the positive.
Happiness is a result of a decision to be happy.
LC 12/06
Dwell on the positive.
Happiness is a result of a decision to be happy.