Hi All,
The findings of this research may explain why so many people with GERD, develop MC:
http://www.medscape.com/viewarticle/715624
Tex
Long-Term PPI Use Leads To SIBO
Moderators: Rosie, Jean, CAMary, moremuscle, JFR, Dee, xet, Peggy, Matthew, Gabes-Apg, grannyh, Gloria, Mars, starfire, Polly, Joefnh
Long-Term PPI Use Leads To SIBO
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Interesting, Tex. I hadn't really made the connection before, but about the time my symptoms started getting worse, I was on a PPI for several weeks to see if it would help my asthma. I was never diagnosed with GERD, but according to my PCP sometimes asthma is made worse by undiagnosed GERD. Also, my voice had gotten progressivly more hoarse, also leading to that suspicion. So I went on a "trial" of a PPI to see if it would improve my symptoms. It didn't do much, except give me some D that seemed to clear up after I quit taking the PPI. But of course the D kept coming back, and worse each time. So I don't know how much the PPI might have contributed since I didn't take it for very long.
Rosie
Rosie
Our greatest weakness lies in giving up. The most certain way to succeed is always to try just one more time………Thomas Edison
Rosie,
There's other evidence of the connection between PPIs and MC, and PPIs and other causes of diarrhea:
http://www.factsandcomparisons.com/asse ... smpadv.pdf
http://www.medscape.com/viewarticle/584079_4
By the way, are you aware that supplemental magnesium can help to reduce spasms of various types, including asthma?
http://www.drbriffa.com/blog/2010/01/29 ... sthmatics/
Tex
There's other evidence of the connection between PPIs and MC, and PPIs and other causes of diarrhea:
http://www.factsandcomparisons.com/asse ... smpadv.pdf
http://www.medscape.com/viewarticle/584079_4
By the way, are you aware that supplemental magnesium can help to reduce spasms of various types, including asthma?
http://www.drbriffa.com/blog/2010/01/29 ... sthmatics/
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Very interesting.... I never, to my knowledge, took PPIs but I do recall that episodes of reflux were becoming more regular for 3 to 4 years before my MC presented as chronic D (I had been diagnosed with hiatus hernia since my late 20s). It seems possible that stuff going on in the small intestines and the colon is likely to be connected. Since going GF, DF, SF I have not had any reflux.
Best, Ant
Best, Ant
Ant,
Here's how I believe that scenario plays out:
Be aware that I haven't seen any published research that verifies this overall theory - it's just my opinion, but consider this:
The primary cause of GERD, is inadequate stomach acid, (not excess stomach acid, as most doctors believe). Most doctors never check stomach acid levels, they just automatically prescribe a PPI, or some other antacid. They simply don't understand what's going on, and they apparently have an overly simplistic viewpoint. There has been some research that substantiates that claim, but I don't recall any references, at the moment. This is a fact: The lower esophageal sphincter senses the pH of the stomach contents, on it's gastric side. If the pH of the stomach is too high, (IOW, if the stomach contents are not sufficiently acidic), the lower esophageal sphincter tends to relax it's "clamping" strength, thus allowing the possibility of reflux of stomach contents. Generally, the lower the pH, the stronger the holding power of the lower esophageal sphincter, and therefore, the lower the likelihood of any reflux.
One of the primary functions of stomach acid, is to kill bacteria, and it does a very effective job of that on most bacterial species, (with certain notable exceptions, one of the most well-known of which is E. coli, for example). Sooooo, it seems a no-brainer to me, that if GERD is a problem, stomach acidity is probably too weak, and over time, this will lead to small intestinal bacterial overgrowth, (SIBO). That would appear to me to be the reason why the repeated or regular use of PPIs, and any other type of antacid, often leads to SIBO. SIBO is a known cause of MC.
IOW, as I see it, this scenario could very easily have created the environment which led to your MC.
Tex
Here's how I believe that scenario plays out:
Be aware that I haven't seen any published research that verifies this overall theory - it's just my opinion, but consider this:
The primary cause of GERD, is inadequate stomach acid, (not excess stomach acid, as most doctors believe). Most doctors never check stomach acid levels, they just automatically prescribe a PPI, or some other antacid. They simply don't understand what's going on, and they apparently have an overly simplistic viewpoint. There has been some research that substantiates that claim, but I don't recall any references, at the moment. This is a fact: The lower esophageal sphincter senses the pH of the stomach contents, on it's gastric side. If the pH of the stomach is too high, (IOW, if the stomach contents are not sufficiently acidic), the lower esophageal sphincter tends to relax it's "clamping" strength, thus allowing the possibility of reflux of stomach contents. Generally, the lower the pH, the stronger the holding power of the lower esophageal sphincter, and therefore, the lower the likelihood of any reflux.
One of the primary functions of stomach acid, is to kill bacteria, and it does a very effective job of that on most bacterial species, (with certain notable exceptions, one of the most well-known of which is E. coli, for example). Sooooo, it seems a no-brainer to me, that if GERD is a problem, stomach acidity is probably too weak, and over time, this will lead to small intestinal bacterial overgrowth, (SIBO). That would appear to me to be the reason why the repeated or regular use of PPIs, and any other type of antacid, often leads to SIBO. SIBO is a known cause of MC.
IOW, as I see it, this scenario could very easily have created the environment which led to your MC.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Tex, all very interesting and makes a lot of sense.
As for taking magnesium, I might give it a try...have been reluctant because magnesium can cause D. And after I went gluten, dairy and soy free, my asthma has improved a lot.
Rosie
As for taking magnesium, I might give it a try...have been reluctant because magnesium can cause D. And after I went gluten, dairy and soy free, my asthma has improved a lot.
Rosie
Our greatest weakness lies in giving up. The most certain way to succeed is always to try just one more time………Thomas Edison
Tex,
Very interesting. Over many years I had taken Gaviscon tablets (sodium alginate, sodium bicarbonate and calcium carbonate) when the 'heartburn' was playing up.
I have never been tested for SIBO and I wonder if extensive use of antibiotics could be an additional cause of SIBO? In my early teens I was treated for osteomalitis with very high oral doses of antibiotics over a three month period (and I also had a fair amount of antibiotics in the ten years leading up to Dx MC - ironically mainly to treat D
).
If my small intestines are/have been messed up, that also fits with osteoporosis developing. Having read some of the old posts on SIBO it seems that it is not too easy to cure. (e.g. Rifaximin is not necessarily effective).
All best, Ant
Very interesting. Over many years I had taken Gaviscon tablets (sodium alginate, sodium bicarbonate and calcium carbonate) when the 'heartburn' was playing up.
I have never been tested for SIBO and I wonder if extensive use of antibiotics could be an additional cause of SIBO? In my early teens I was treated for osteomalitis with very high oral doses of antibiotics over a three month period (and I also had a fair amount of antibiotics in the ten years leading up to Dx MC - ironically mainly to treat D
). If my small intestines are/have been messed up, that also fits with osteoporosis developing. Having read some of the old posts on SIBO it seems that it is not too easy to cure. (e.g. Rifaximin is not necessarily effective).
All best, Ant
Yes, antibiotics can definitely lead to SIBO, (especially if used repeatedly), and if SIBO has been a problem for many years, it might be more difficult to correct, but that's just a guess. I believe you're right, though, correcting it can be quite a project.Ant wrote:I have never been tested for SIBO and I wonder if extensive use of antibiotics could be an additional cause of SIBO?
To be honest, I'm not sure how effective it is for combating SIBO. If I recall correctly, most of the members of this board who used it, used it to try to control MC, (not necessarily SIBO), and it's not likely to be of much help to control the inflammation of MC, unless other treatments are in place, (such as the diet). IOW, if an MC reaction is raging, it's pretty difficult to tell if any progress is being made on a SIBO treatment. That's kind of like cutting gluten out of your diet. If you are sensitive to gluten, and you don't cut it out first, it's almost impossible to accurately detect whether any other food is a problem, based on clinical symptoms.Ant wrote:Rifaximin is not necessarily effective
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.