GS as a Neurological Illness - Hadjivassiliou

JLH · Post by **JLH** » Tue May 24, 2011 9:55 am

When I called Enterolab regarding my 0603 and chances of neurological problems, they told me Dr. Hadjivassiliou's research was the place to find out about it.

http://www.ncbi.nlm.nih.gov/pmc/article ... p00560.pdf

Zizzle · Post by **Zizzle** » Tue May 24, 2011 11:37 am

Very interesting. Thanks for posting. It must be hard to convince patients to go GF when they don't have troublesome GI symptoms like we do. Especially if they are not likely to have overnight improvement of their neurological problems. I wonder if "limiting" gluten would help in these people, or if the neurological issues are also all-or-nothing like MC and CD.

sarkin · Post by **sarkin** » Tue May 24, 2011 1:19 pm

I sent that very article to a friend with unexplained, occasional dizziness. He believes he may have 'atypical migraine without headache' (this is a very, very smart, science-educated man). And he may be right - I say that if it's migraine, it's still autoimmune, and if it quacks like a gluten... I sent him this very article, and tried not to ask whether he wonders about this being early-stage gluten ataxia. He also has biopsy-confirmed Hashimoto's, not yet symptomatic. (I didn't ask, how did you just happen to have a thyroid biopsy?? - I'm guessing it had to do with Dx-ing the dizziness - which never happened, btw.)

Well, you all know what *I* think. I'm going to see whether I can manage my "get tested" conversation with my brother successfully, before moving onto friends.

Interesting article, indeed. I don't know whether "limiting" would be partially effective, and I would guess that even with a completely GF diet, improvement of neuro symptoms would depend on the nature of the damage, and how long it had been going on. I had had my finger-thumb numbness for at least a year or two, and it went away very rapidly after I corrected my diet. Yes, you saw that verb right... I already had a 'restricted' diet in that I didn't eat things I disliked, or knew were unhealthful... I have now 'corrected' it ;) That's not my cheery attitude, btw - that's me "having an attitude." Heh.

I think a lot of people aren't trouble by neuro symptoms till they're pretty bad. I didn't think much about my thumb-finger numbness, which I now understand to be peripheral neuropathy. A little dizziness here, a funny feeling in a finger there, no wonder it's so hard to believe it could be diet, when even gastro problems don't get ascribed to diet. Sigh...

Joan, are you having neuro symptoms now, and have they improved? My genes were different, and didn't come with that warning - but I'm strongly persuaded I was having that problem because of gluten. It not only went away with proper diet, it came back when I got glutened - literally, the next day. So in my case, I would guess that it wouldn't take much gluten to perpetuate/exacerbate the problem. But that might be partly because of the 0201/0202 double whammy?

L,
S

MBombardier · Post by **MBombardier** » Wed May 25, 2011 12:05 pm

Characterisation of the anti-Purkinje cell antibodies by immunoblotting may provide a useful marker for the diagnosis of gluten ataxia in a manner analogous to the use of antiendomysium antibodies as a marker for coeliac disease or the anti-Yo antibody in paraneoplastic cerebellar degeneration.

That sentence gave me neurological damage, lol.

This is not exactly pertinent to the neurological issues discussed in this article (which I have never had but my father does). But it made me think about how if I accidentally ingest a food to which I am intolerant that the foggy brain happens fairly quickly and takes a while to dissipate. It seems to be fairly intense, too. I feel like I go from a highly-functioning, intelligent human being to a weak-witted amnesiac. Possibly the most annoying thing is the effect on my children, who feel like they need to "help" me, even after I have obviously regained the sunny skies in my brain.

It made me wonder just how elastic a brain can be, and how much other parts of the brain can compensate for those that are damaged, like the cerebellar damage discussed in the article.

This is an interesting website:

http://www.ihop-net.org/UniPub/iHOP/

It will tell you the diseases that researchers have discovered that your genes are associated with. I was intrigued to see that the GS gene that I have (not the celiac gene) is associated with diabetes, which my father has.

Gloria · Post by **Gloria** » Wed May 25, 2011 4:14 pm

Marliss,

You must have less brain fog than me because I didn't have a clue how to search my genes on that website. Can you explain what you entered and where you entered it?

Gloria

irisheyes13 · Post by **irisheyes13** » Wed May 25, 2011 4:26 pm

Gloria,

You took the words right outta my mouth! Maybe I'm having one of those brain fog kinda days because I spent the last half hour trying to do the same thing and just got too frustrated. It is an intriguing search site.

Marliss, I believe Gloria and I both share the same non celiac 0501 gene (which I also share with my daughter who has t1 diabetes), if I'm not mistaken in my brain fog haze... please share how you searched and if you don't mind, the specific research on the link to diabetes. I know the celiac gene which she has is linked to diabetes but haven't seen where the DQB1-0501 associated. Thanks in advance.

Sara- It's great to *see* you:)

MBombardier · Post by **MBombardier** » Wed May 25, 2011 8:44 pm

My father has type 2 diabetes, not type 1. I can't find the article I was looking at. So annoying when that happens. I did find one on type 1 in relation to 0302 which you already know about.

Okay, on the first page where it says "search for a gene synonym" plug in dqb1 > all fields > homo sapiens and click on the search button.

On the second page, one line will come up that says "TOR1B torsin family 1, member B (torsin B) DQ1 Homo sapiens". You can click on any of the first three and "see information for this gene." What I do, though, is click on the button in the "results" at the end of that line that says "interactive information for this gene" when you mouse across it.

On the results page, you can either do a ctrl F or click on "find on this page" in the upper right. If you plug 0302 in the search box that pops up, you get four results, all four of which relate to genetic susceptibility to type 1 diabetes, including one called "Genetic susceptibility to type 1 diabetes: clinical and molecular heterogeneity of IDDM1 [?] and IDDM12 in a german population.". if you click on this article, on the bottom right there is a button where you can look at links to related articles.

There is a stunning amount of information on this database, and it is always up-to-date, or so they say. I like the WikiGenes part, too, because it seems easier to read than the main data stream.

Enjoy, ladies. If you still have problems, let me know.