Hi All,
It’s been a while since I’ve written anything on the forum - I’ve been checking in periodically, but have not posted. I wanted to see if any one else has had these issue. I was on Entocort for 4 1/2 months and was gradually weaned off. Two weeks later I had a relapse. I believe some of the relapse was from food sensitivities, although the one I was consuming the most - ginger was low on the list. My regular GI was out of town and I was going away on a family vacation, so I opted to go back on the generic form of the Entorcort. It got rid of the D, however my stomach was very sore - 24/7 and never really cleared up after a month. I went to see my GI and he said it sounded like gastritis, and the budesonide could be causing it. I went online and checked the side effects and that was one of them. He also said the generic and the brand name are suppose to be the same but who knows what the fillers are, maybe even gluten?? I assumed since I had done so well on the Entercort the first go around that there would be no problem with the generic. He ordered a H-pylori test, and an ultrasound - both came back negative. I went on Pepcid over the counter as recommended by my GI and that got rid of the sore stomach.On my last visit to my GI, he said go off everything. I was down to one pill a day of the budesonide. I went another two weeks - one pill a day and one every other day. Two weeks later my stools started getting really loose again, so I went into precautionary diet mode - cock pot chicken and rice. That has helped tighten them up but my stomach is always gurgling. I’ve taken Pepcid for two nights but still can't say it dramatically stopped the gurgling and I’m not sure if I should be avoiding this kind of medication or not?? I know the gurgling is not from the celiac, since I’m soooo careful. I’m assuming it’s the MC that is causing this. My ND did food sensitivity testing and I've been avoiding everything on the list since the first time I went off Entocort.
So has anyone had gastritis- stomach ulcer- due to Entocort? Has anyone noticed a difference in the way you feel between the generic and the Brand name Entocort?
Thanks Lassie
Gastritis from Entocort - or felt different on the generic?
Moderators: Rosie, Stanz, Jean, CAMary, moremuscle, JFR, Dee, xet, Peggy, Matthew, Gabes-Apg, grannyh, Gloria, Mars, starfire, Polly, Joefnh
Hi Lassie,
To be honest, I've never heard of Entocort having a negative effect on gastritis, let alone causing it. I believe that would have to be a pretty rare situation. We have quite a few members who are using Budez CR, (a form of generic budesonide), and all the reports that I've seen indicate that it works just as well as the name brand product.
The generic version of Entocort sold by Par pharmaceuticals is actually an authorized generic, meaning that it's exactly the same as Entocort EC in every way (it's even made by AstraZeneca) - it just comes in a bottle with a generic name. I have no idea what's in the generic version made by Mylan Pharmaceuticals, though, or the Budez CR.
On the other hand, histamine-2 receptor blockers, (such as Pepcid), have been implicated in triggering MC, or causing relapses, similar to the PPIs.
H. pylori can be very difficult to diagnose. Some people have to repeat the tests several times before getting a positive result.
Are you also avoiding dairy and soy? Those are the main problems for most of us, after gluten.
Tex
To be honest, I've never heard of Entocort having a negative effect on gastritis, let alone causing it. I believe that would have to be a pretty rare situation. We have quite a few members who are using Budez CR, (a form of generic budesonide), and all the reports that I've seen indicate that it works just as well as the name brand product.
The generic version of Entocort sold by Par pharmaceuticals is actually an authorized generic, meaning that it's exactly the same as Entocort EC in every way (it's even made by AstraZeneca) - it just comes in a bottle with a generic name. I have no idea what's in the generic version made by Mylan Pharmaceuticals, though, or the Budez CR.
On the other hand, histamine-2 receptor blockers, (such as Pepcid), have been implicated in triggering MC, or causing relapses, similar to the PPIs.
H. pylori can be very difficult to diagnose. Some people have to repeat the tests several times before getting a positive result.
Are you also avoiding dairy and soy? Those are the main problems for most of us, after gluten.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
-
framedame
- Little Blue Penguin
- Posts: 34
- Joined: Mon Mar 07, 2011 2:29 pm
- Location: Waterbury Center, VT
Hi Tex,
I have been soy free, dairy free - no oats, corn or eggs for months. Egg whites were high for IGG and I had been consuming them durng the first round with Entocort. The second round with Budesonide I was not eating any of the foods listed above. I have had an ulcerated stomach about 15 years ago when I had a back problem after taking Motrin for a month. I had an endoscopy and it showed slight ulceration of the stomach, so I was put on every acid blocker on the planet ,with no positive results of easing the pain. It took me a year to finally recover. This last time I was on the budesonide it felt just like I had 15+ years ago - right in the upper stomach. Also, I would eat to feel better than shortly after my pain would return.
I'm stopping the Pecid asap. Will the gurgling go away. What does it represent if I don't have D?
I have been soy free, dairy free - no oats, corn or eggs for months. Egg whites were high for IGG and I had been consuming them durng the first round with Entocort. The second round with Budesonide I was not eating any of the foods listed above. I have had an ulcerated stomach about 15 years ago when I had a back problem after taking Motrin for a month. I had an endoscopy and it showed slight ulceration of the stomach, so I was put on every acid blocker on the planet ,with no positive results of easing the pain. It took me a year to finally recover. This last time I was on the budesonide it felt just like I had 15+ years ago - right in the upper stomach. Also, I would eat to feel better than shortly after my pain would return.
I'm stopping the Pecid asap. Will the gurgling go away. What does it represent if I don't have D?
Thanks for the extra background information. I believe I can visualize what's happening, now. It appears that you have on-going stomach issues, probably H. pylori, but it could be something else, as well. 
Here's what I believe is happening:
Bearing in mind that normally, every cell in the lining of the stomach is replaced on approximately a weekly basis, (this is done to prevent the stomach from digesting itself), even though H. pylori, (or some other pathogen), is causing regular damage in your stomach, the body is able to handle it without major problems, because the normal healing process, (weekly replacement of all the cells in the epithelia), is able to keep up with the rate of damage, so that the stomach can function pretty much normally. (Most people who have an H. pylori problem never have any significant symptoms).
Any corticosteroid retards healing, so when you take budesonide, the replacement rate of the epitheilal cells in the stomach is significantly decreased, resulting in a backlog, (accumulation), of damaged cells that should have been replaced, but were not, (at least, not in a timely manner), due to the compromised healing rate. This causes the symptoms of gastritis to become prominent, due to the proliferation of damaged cells.
IMO, (and this is strictly my opinion), the gurgling noise is caused by incomplete digestion, resulting in the fermentation of foods. Inadequate stomach acid tends to cause the problem, because without sufficient acidity, the chyme is dumped into the small intestine prematurely, (that is, with minimal digestion progress), and the small intestine is unable to continue the digestive process properly, (because it wasn't properly pre-digested), and so bacteria take over, and the food spoils, (IOW, the food is fermented). The fermentation process results in the release of a lot of gas, and the production of various chemicals and toxins, which can cause other symptoms, (often including D, of course). The gurgling is caused by the gas generated by the decomposing food, as it percolates through the intestines.
Pepcid causes a decrease in stomach acidity, and therefore causes incomplete pre-digestion, resulting in further digestive failure, as the chyme travels downstream. In addition, one of the primary functions of stomach acid is to kill food-borne bacteria, (it won't kill all species, of course, but it can control most of them), so when an acid buffer, or a PPI is used, food-borne bacteria are more likely to survive the trip through the stomach, and once they reach the environment in the intestines, (with a near-neutral pH), they have it made, and they happily go right to work, fermenting food.
If this is going on without D, then that suggests that the intestines are probably not significantly inflamed, and they are absorbing nutrients pretty much normally, (malabsorption of certain electrolytes is necessary to promote D, and with MC, not only malabsorption, but infusion of electrolytes into the lumen, is a common problem, which, of course, results in secretory D). The absence of D suggests that your symptoms may not be associated with active MC, but mostly with what is going on in your stomach.
That's just my unprofessional opinion, but that's what I think is happening.
Tex
Here's what I believe is happening:Bearing in mind that normally, every cell in the lining of the stomach is replaced on approximately a weekly basis, (this is done to prevent the stomach from digesting itself), even though H. pylori, (or some other pathogen), is causing regular damage in your stomach, the body is able to handle it without major problems, because the normal healing process, (weekly replacement of all the cells in the epithelia), is able to keep up with the rate of damage, so that the stomach can function pretty much normally. (Most people who have an H. pylori problem never have any significant symptoms).
Any corticosteroid retards healing, so when you take budesonide, the replacement rate of the epitheilal cells in the stomach is significantly decreased, resulting in a backlog, (accumulation), of damaged cells that should have been replaced, but were not, (at least, not in a timely manner), due to the compromised healing rate. This causes the symptoms of gastritis to become prominent, due to the proliferation of damaged cells.
IMO, (and this is strictly my opinion), the gurgling noise is caused by incomplete digestion, resulting in the fermentation of foods. Inadequate stomach acid tends to cause the problem, because without sufficient acidity, the chyme is dumped into the small intestine prematurely, (that is, with minimal digestion progress), and the small intestine is unable to continue the digestive process properly, (because it wasn't properly pre-digested), and so bacteria take over, and the food spoils, (IOW, the food is fermented). The fermentation process results in the release of a lot of gas, and the production of various chemicals and toxins, which can cause other symptoms, (often including D, of course). The gurgling is caused by the gas generated by the decomposing food, as it percolates through the intestines.
Pepcid causes a decrease in stomach acidity, and therefore causes incomplete pre-digestion, resulting in further digestive failure, as the chyme travels downstream. In addition, one of the primary functions of stomach acid is to kill food-borne bacteria, (it won't kill all species, of course, but it can control most of them), so when an acid buffer, or a PPI is used, food-borne bacteria are more likely to survive the trip through the stomach, and once they reach the environment in the intestines, (with a near-neutral pH), they have it made, and they happily go right to work, fermenting food.
If this is going on without D, then that suggests that the intestines are probably not significantly inflamed, and they are absorbing nutrients pretty much normally, (malabsorption of certain electrolytes is necessary to promote D, and with MC, not only malabsorption, but infusion of electrolytes into the lumen, is a common problem, which, of course, results in secretory D). The absence of D suggests that your symptoms may not be associated with active MC, but mostly with what is going on in your stomach.
That's just my unprofessional opinion, but that's what I think is happening.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.