Proof that oral/allergy tolerance does not = gut tolerance

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Zizzle
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Proof that oral/allergy tolerance does not = gut tolerance

Post by Zizzle »

In mice, at least...

Tex is right (of course)

Here's a study showing that oral immunotherapy for food allergens can indeed reduce the IgE reaction (and most symptoms) to the food, but it does nothing to prevent the ongoing intestinal inflammation caused by the food allergen. This is evidence that even for those people who "outgrow" food allergies, they should still not eat the offending food proteins.

http://onlinelibrary.wiley.com/doi/10.1 ... aintenance



Here's another study that found 25% of IBS patients had food hypersensitivity, as measured by tryptase and eosinophil cationic protein (ECP) in the stool.

http://www.cghjournal.org/article/S1542 ... 7/abstract
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tex
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Post by tex »

Wow! Thanks for that first reference. I've been looking for a reference to support my claims about that issue, but as you know, if we don't happen to select the correct key words for the search, either the result we're looking for is buried behind hundreds or thousands of other hits, or we miss the boat completely.

Many thanks,
Tex
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It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
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MBombardier
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Post by MBombardier »

Aha. Proof. How many times have we been asked by well-meaning friends and family, "Well, if you keep eating it, won't you develop a tolerance to it?"

Or gotten comments like: "You were [age] before you started having problems. I bet if you go back to eating it, your body will adjust and you won't have problems any more."
Marliss Bombardier

Dum spiro, spero -- While I breathe, I hope

Psoriasis - the dark ages
Hashimoto's Thyroiditis - Dec 2001
Collagenous Colitis - Sept 2010
Granuloma Annulare - June 2011
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Zizzle
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Post by Zizzle »

You're welcome. I had a hunch you'd find it useful.
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tex
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Post by tex »

Yep, I just added another paragraph to chapter 9.

Thanks again,
Tex
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It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
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wonderwoman
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Post by wonderwoman »

Tex, when do you expect that book to be done? I want a copy immediately after it comes off the press.
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tex
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Post by tex »

Hi Charlotte,

It will probably be about a month. I'm still adding editing changes and after that I'll need to give it a final going over to make all the paragraphs and sentences fit the pages correctly, and add an index and a couple of other things.

Tex
:cowboy:

It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
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