Feel free to discuss any topic of general interest, so long as nothing you post here is likely to be interpreted as insulting, and/or inflammatory, nor clearly designed to provoke any individual or group. Please be considerate of others feelings, and they will be considerate of yours.
Ranitidine, diarrhoea, and lymphocytic colitis. Gut 37: 708 – 711
A case of drug-induced LC from taking Zantac.
A 69 year old woman developed chronic diarrhoea while being treated with ranitidine. Sigmoidoscopy was performed after six weeks and showed typical histological features of lymphocytic colitis. Ranitidine was withdrawn and the diarrhoea resolved. Eight months later, a 72 hour oral rechallenge period of ranitidine, was performed immediately preceded (period 1) and followed (period 2) by sigmoidoscopy and biopsy. Diarrhoea recurred during the rechallenge period and resolved again within one day after drug withdrawal.
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Greater risk of food allergies after taking H2 blockers and other drugs for GERD...
H2 antagonists may increase the risk of developing food allergies. Patients who take these agents develop higher levels of IgE against food, whether they had prior antibodies or not. Even months after discontinuation there was still an elevated level of IgE in 6% of patients in this study.
ditto
love the stuff you find and share - keep em coming!
(i may not always comment but i do read the articles)
i had been taking the H2 blocker rantadine, but knew it was a bandaid to the inflammation issues. the current treatments i am doing is to try and remove the cause of the inflammation issues...
Gabes Ryan
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
Zizzle, have have noticed anything similar on PPIs and diarrhea? I was put on PPIs twice. The first time after several months all my acid shut down and I thought I was gonna die. The second time I was OK for 5 weeks and then the D started.
Now I just take Bet HCL - the exact opposite of acid blockers - and feel so much better.
The evidence on PPIs causing MC is more abundant than this, from what we read here from Tex and others. I posted this info because many here think Zantac is safer, and/or use it to manage mast cell activation issues.
Sad truth is, there are no safe drugs. For every medicinal benefit, there is an undesirable side effect.
I'm also concerned about Zantac and PPIs because a huge proportion of infants are prescribed them due to reflux. My daughter took Zantac from 8 weeks to 6 months of age. Could this be one reason for the rise of food allergies in kids?
Question for Polly, the pediatrician:
Is there any way you could do a quick chart review of some of your food allergic patients to see if any were given Zantac or PPIs as infants for reflux? I'm dying to know if there is any correlation!
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Wheat harvest has been slowing me down but I'm almost finished editing Chapter 15. I'm slowly but surely gettin' there.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Ah, yes, the wheat harvest. We have about 5 acres that also has wheat waiting to be harvested. (We let a local farmer use the land gratis; it's pretty to see.)
I had a thought about the wheat fields being nearby: what does having all that gluten around mean for us G-F types? Apparently it's OK as long as it's still in unprocessed form. LOL
For me at least, wheat doesn't seem to be a problem as long as I keep it out of my mouth. I try to minimize inhaling wheat dust, of course, but I'm not sure that wheat dust is any more of a problem than any other grain dust -- none of it is good for our lungs. I can handle the grain (bare skin contact) without any problems.
I still need to reformat the text for printing and do the final design work on the layout, and I need to do an index, glossary, and a few other things, and finalize the cover design.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Tex, I don't know how you find the time to write a book when you must spend hours replying to all the posts here. And then there is all the research you must do.
Tex, I too was wondering how you could harvest wheat when you are gluten intollerant.
I have been back here reading the posts for about a month now but I can't always take the time to comment. Thank goodness there are others out there that can help those in need by offering their suggestions. I am getting to know the newbies here and can sympathize with their struggles.
I got my results back from EnteroLab but haven't had time to post them. What a shock. I will need to do a lot of changes regarding my diet. I have questions regarding the results but they will have to wait.
BM's are mostly Normans with taking Entocort. I am alternating between 2 one day and 1 the next.
