Hi all.
Remember I was trying to figure out why I had perfect normans on my camping trip? When I am away from home, I usually need to take a couple of Tylenol PMs to help me sleep.
Well, last night I was having problems getting to sleep and I took a couple. This morning, I had no BM ( VERY UNUSUAL). Didn't go until around 2 PM.
That's when It dawned on me that maybe it was the PMs! Could it be?
Leah
could it have been the sleeping pill?
Moderators: Rosie, Stanz, Jean, CAMary, moremuscle, JFR, Dee, xet, Peggy, Matthew, Gabes-Apg, grannyh, Gloria, Mars, starfire, Polly, Joefnh
Each gelcap/geltab/caplet of TYLENOL® PM contains
500 mg of the pain reliever, acetaminophen,
and 25 mg of the sleep aid, diphenhydramine HCl.
So, I looked up diphenhydramine and got:
Diphenhydramine is a potent anticholinergic agent. This activity is responsible for the side effects of dry mouth and throat, increased heart rate, pupil dilation, urinary retention, constipation, and, at high doses, hallucinations or delirium. Other side-effects include motor impairment (ataxia), flushed skin, blurred vision at nearpoint owing to lack of accommodation (cycloplegia), abnormal sensitivity to bright light (photophobia), sedation, difficulty concentrating, short-term memory loss, visual disturbances, irregular breathing, dizziness, irritability, itchy skin, confusion, decreased body temperature (in general, in the hands and/or feet), erectile dysfunction, excitability, and, although it can be used to treat nausea, higher doses may cause vomiting.[15] Some side effects, such as twitching, may be delayed until the drowsiness begins to cease and the person is in more of an awakening mode.
Also found this:
Diphenhydramine is a first-generation antihistamine used to treat a number of conditions including allergic symptoms and itchiness, the common cold, insomnia, motion sickness and extrapyramidal symptoms.
Diphenhydramine is significantly more potent in treatment of allergies than a newer generation of antihistamines.[7] Consequently, it is frequently used when an allergic reaction requires fast, effective reversal of a massive histamine release. Diphenhydramine is available as an over-the-counter drug (OTC) or prescription-only solution for injection. Injectable diphenhydramine can be used for life-threatening reactions (anaphylaxis) to allergens such as bee stings, peanuts, or latex, as an adjunct to epinephrine.[8]
Diphenhydramine is an inverse agonist of the histamine H1 receptor.[28] It is a member of the ethanolamine class of antihistaminergic agents.[16] By reversing the effects of histamine on the capillaries, it can reduce the intensity of allergic symptoms. Diphenhydramine also crosses the blood–brain barrier (BBB) and antagonizes the H1 receptors centrally. Its effects on central H1 receptors cause drowsiness.[29]
Like many other first-generation antihistamines, diphenhydramine is also a potent antimuscarinic (a competitive antagonist of muscarinic acetylcholine receptors), and, as such, at high doses can cause anticholinergic syndrome.[30] The utility of diphenhydramine as an antiparkinson agent is the result of its blocking properties on the muscarinic acetylcholine receptors in the brain.
Diphenhydramine also acts as an intracellular sodium channel blocker, which is responsible for its actions as a local anesthetic.[31] Diphenhydramine has also been shown to inhibit the reuptake of serotonin.[32] Finally, diphenhydramine has been shown to be a potentiator of analgesia induced by morphine in rats
500 mg of the pain reliever, acetaminophen,
and 25 mg of the sleep aid, diphenhydramine HCl.
So, I looked up diphenhydramine and got:
Diphenhydramine is a potent anticholinergic agent. This activity is responsible for the side effects of dry mouth and throat, increased heart rate, pupil dilation, urinary retention, constipation, and, at high doses, hallucinations or delirium. Other side-effects include motor impairment (ataxia), flushed skin, blurred vision at nearpoint owing to lack of accommodation (cycloplegia), abnormal sensitivity to bright light (photophobia), sedation, difficulty concentrating, short-term memory loss, visual disturbances, irregular breathing, dizziness, irritability, itchy skin, confusion, decreased body temperature (in general, in the hands and/or feet), erectile dysfunction, excitability, and, although it can be used to treat nausea, higher doses may cause vomiting.[15] Some side effects, such as twitching, may be delayed until the drowsiness begins to cease and the person is in more of an awakening mode.
Also found this:
Diphenhydramine is a first-generation antihistamine used to treat a number of conditions including allergic symptoms and itchiness, the common cold, insomnia, motion sickness and extrapyramidal symptoms.
Diphenhydramine is significantly more potent in treatment of allergies than a newer generation of antihistamines.[7] Consequently, it is frequently used when an allergic reaction requires fast, effective reversal of a massive histamine release. Diphenhydramine is available as an over-the-counter drug (OTC) or prescription-only solution for injection. Injectable diphenhydramine can be used for life-threatening reactions (anaphylaxis) to allergens such as bee stings, peanuts, or latex, as an adjunct to epinephrine.[8]
Diphenhydramine is an inverse agonist of the histamine H1 receptor.[28] It is a member of the ethanolamine class of antihistaminergic agents.[16] By reversing the effects of histamine on the capillaries, it can reduce the intensity of allergic symptoms. Diphenhydramine also crosses the blood–brain barrier (BBB) and antagonizes the H1 receptors centrally. Its effects on central H1 receptors cause drowsiness.[29]
Like many other first-generation antihistamines, diphenhydramine is also a potent antimuscarinic (a competitive antagonist of muscarinic acetylcholine receptors), and, as such, at high doses can cause anticholinergic syndrome.[30] The utility of diphenhydramine as an antiparkinson agent is the result of its blocking properties on the muscarinic acetylcholine receptors in the brain.
Diphenhydramine also acts as an intracellular sodium channel blocker, which is responsible for its actions as a local anesthetic.[31] Diphenhydramine has also been shown to inhibit the reuptake of serotonin.[32] Finally, diphenhydramine has been shown to be a potentiator of analgesia induced by morphine in rats
Linda :)
LC Oct. 2012
MTHFR gene mutation and many more....
LC Oct. 2012
MTHFR gene mutation and many more....
Linda,
Good detective work.
There are a surprising number of drugs prescribed for various purposes that also happen to have powerful antihistamine properties.
Diphenhydramine is most commonly known as Benadryl, of course.
EDIT: Oops, I see that Gloria posted while I was writing. Good catch, Gloria!
Tex
Good detective work.
There are a surprising number of drugs prescribed for various purposes that also happen to have powerful antihistamine properties.
Diphenhydramine is most commonly known as Benadryl, of course.
EDIT: Oops, I see that Gloria posted while I was writing. Good catch, Gloria!
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
