Question for Tex, Dr Ann or any other person reading /researching this stuff....
Just pondering, could methylation issues be a major contributor ??cause ?? to mast cell/histamine issues...
???? Could methylation issues be cause of mast cells?
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Gabes-Apg
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???? Could methylation issues be cause of mast cells?
Gabes Ryan
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
Hi Gabes,
This is a rather complex topic, and I have to point out right up front that I really don't know all that much about the ins and outs of methylation. According to my research (as per the vitamin D book) mast cell numbers and activity are mostly regulated by the active form of vitamin D. The expression of vitamin D receptors is even the mechanism by which corticosteroids suppress mast cell numbers and degranulation. IOW, corticosteroids suppress inflammation by exploiting/enhancing the ability of the active form of vitamin D to modulate mast cell development/maturity and sensitivity/activity.
Vitamin D undergoes 2 hydroxylation processes during the conversion into the active form (the first occurs in the liver and the second occurs in the kidneys, although small scale conversions can occur elsewhere, when needed). I'm not aware that methylation is involved in either process, but I really don't know enough about methylation at this point to rule out the possibility that methylation might somehow be indirectly involved in either of those conversions, or involved at some other level (independent of vitamin D).
I have a hunch that since methylation issues tend to lead to immune system and inflammation problems, certain compromised methylation processes probably are somehow associated with mast cell destabilization, but due to my ignorance I'm unable to elucidate any examples at this point.
Tex
This is a rather complex topic, and I have to point out right up front that I really don't know all that much about the ins and outs of methylation. According to my research (as per the vitamin D book) mast cell numbers and activity are mostly regulated by the active form of vitamin D. The expression of vitamin D receptors is even the mechanism by which corticosteroids suppress mast cell numbers and degranulation. IOW, corticosteroids suppress inflammation by exploiting/enhancing the ability of the active form of vitamin D to modulate mast cell development/maturity and sensitivity/activity.
Vitamin D undergoes 2 hydroxylation processes during the conversion into the active form (the first occurs in the liver and the second occurs in the kidneys, although small scale conversions can occur elsewhere, when needed). I'm not aware that methylation is involved in either process, but I really don't know enough about methylation at this point to rule out the possibility that methylation might somehow be indirectly involved in either of those conversions, or involved at some other level (independent of vitamin D).
I have a hunch that since methylation issues tend to lead to immune system and inflammation problems, certain compromised methylation processes probably are somehow associated with mast cell destabilization, but due to my ignorance I'm unable to elucidate any examples at this point.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
