Reversal of Aging

[nerdhume]

http://mobile.abc.net.au/news/2014-11-0 ... ce/5865714

The clinical trials were small studies but showed promising results in humans, he said.

"They show that the molecules that extend lifespan in mice are safe in people; they seem to be anti-inflammatory, so they might be useful against disease's inflammation, like skin redness or even inflammatory bowel disease," he said.

The article also mentioned resveratrol, quick search turned up this interesting article:
http://aguywithcrohns.com/tag/resveratrol/

There has been a lot of research apparently. Here is one abstract:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835444/

[tex]

Theresa,

Regarding the article on reversing aging: Gee, I wonder if that would sell if they could come up with a commercially-feasible process or pill?

Of course it would be nice if they were to actually come up with something worthwhile, but claims of reversing aging within a week (in a mouse) seem a bit extravagant (and premature, to boot). It reminds me of the hype that precedes most "snake oil". I'll try to remain open-minded on this one, but I have a hunch that caveat emptor is the order of the day.

The resveratrol shows a lot more promise of actually being beneficial, IMO.

This could be at least part of the reason why the incidence of Crohn's disease is lower in Italy than in other countries (because of wine consumption).

RESULTS: From 1989 to 1992, 509 ulcerative colitis (UC), 222 Crohn's disease (CD) and 10 undefined IBD cases were collected, giving age-adjusted incidence rates (per 100,000 per year) of 5.2 for UC and 2.3 for CD. Using the capture-recapture method, an estimated completeness of 0.81 was obtained for case archives, without appreciable and significant differences between areas. The rates computed after correcting underestimation were 6.8 for UC and 2.8 for CD. The sex ratio M/F was 1.7 for UC and 1.0 for CD. The highest age-specific incidence rates were between 30 and 39 years for UC and between 20 and 29 years for CD.

CONCLUSIONS:
The incidence rate of CD in italy is homogeneous between the cities investigated and lower than those reported for other Mediterranean countries. In contrast, the UC incidence rate is within the range of those reported in European studies. A wide variability in the UC rates between the cities was also observed. These results could be related to different environmental factors or the genetic background of the populations, or both.

Incidence of inflammatory bowel disease in Italy: a nationwide population-based study. Gruppo Italiano per lo Studio del Colon e del Retto (GISC)

In another study, France didn't quite do quite as well as Italy, but it still came out far better than most of Europe, and the study showed that vitamin D appears to be a factor for Crohn's (because of latitude/sun exposure), but apparently not for UC.

RESULTS: In the overall population, incidence rates were 8.2 for CD and 7.2 for UC per 100,000 inhabitants. A clear north-south gradient was shown for CD. Départements with the highest smoothed RR were located in the northern third of France.

CONCLUSIONS: This study shows a north-south gradient in France for CD but not for UC.

Geographical variations of inflammatory bowel disease in France: a study based on national health insurance data.

World-wide, IBDs are much more common. Remember that "incidence" refers to new cases reported annually, whereas "prevalence" refers to all known cases at any given time.

Results: The highest annual incidence of UC was 24.3 per 100,000 person-years in Europe, 6.3 per 100,000 person-years in Asia and the Middle East, and 19.2 per 100,000 person-years in North America. The highest annual incidence of CD was 12.7 per 100,000 person-years in Europe, 5.0 person-years in Asia and the Middle East, and 20.2 per 100,000 person-years in North America. The highest reported prevalence values for IBD were in Europe (UC, 505 per 100,000 persons; CD, 322 per 100,000 persons) and North America (UC, 249 per 100,000 persons; CD, 319 per 100,000 persons).

Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review

Of course Germany didn't do too badly in this study, and beer is supposedly the beverage of choice in Germany.

RESULTS: In total, 286 newly diagnosed patients with IBD were reported in this region, 168 patients suffering from Crohn's disease (CD), 105 patients with ulcerative colitis. Age-standardized incidence rates were 11.0/10(5) (95% CI: 9.1-11.6) for IBD, 6.6/10(5) (95% CI: 5.6-7.7) for CD and 3.9/10(5) (95% CI: 3.2-4.7) for ulcerative colitis. Peak incidences were found in the age interval of 16-24 years for both diseases, predominantly for CD. Age at first diagnosis was lower, extraintestinal manifestations and a positive family history on IBD were more common in patients with CD.

CONCLUSION: The incidence rate in IBD seems to be stable in Germany as compared with previously reported data, as is the remarkable predominance of CD. Prospective follow-up studies will be based on this incidence cohort.

The incidence of inflammatory bowel disease in a rural region of Southern Germany: a prospective population-based study.

Thanks for the links,
Tex

[Gabes-Apg]

or is it that people in european countries like Italy, France, Germany follow the eating plan that they are genetically meant to be eating??

The french have been eating croissant type pastries since the middle ages...

[nerdhume]

or is it that people in european countries like Italy, France, Germany follow the eating plan that they are genetically meant to be eating??

The french have been eating croissant type pastries since the middle ages...

The French never eat anything that is not covered with butter and cream

While America has gone on a fat free craze for years.

When I had blood sugar issues I did a lot of research on the Glycemic index. It defies common sense. A roll covered in butter has less impact than a plain roll or a roll with low fat spread of some sort. Pancakes with ham or bacon is better tolerated than pancakes alone. I could only have a donut for breakfast if I wanted to pass out before lunch. Those things that make blood sugar rise fast make it drop just as fast.

There have been attempts to tie several ailments to blood sugar fluctuations. Now that I am on a restricted diet the blood sugar seems to have calmed down.

[tex]

I agree with you. The mainstream medical community focuses on cholesterol, when they should be focusing on blood sugar.

Tex