Methylation Cycle -

[Gabes-Apg]

For those with the genetic genie methylation report (from 23andme data)
this site (thanks Donna P ) has some good explanations of the genetic variables and what it means for your methylation cycle.

We discuss Vit D supplementation alot and I found this part interesting. What your Vit D receptor Genes status is (and your gene status of other key genes linked to methylation) - may explain how you respond to Vit D supplementation - as it is linked with the methylation cycle...

Like most things in MC world, there is no black and white or easy summary to all of this, each individuals variables of multiple gene mutations affect things. Albeit it does explain why someone will have fantastic response to a diet change or supplement change within weeks, and why another person it may take months to see benefit or they dont feel it is helping them at all.

http://www.heartfixer.com/AMRI-Nutrigenomics.htm#MTR:  Methionine Synthase

Individuals with a normal Vitamin D receptor, those who are VDR Taq (-/-), make plenty of dopamine. They tend not to need or to tolerate methyl groups or dopamine precursor substances. With respect to methyl group need and tolerance, they behave like COMT (+) individuals. Individuals (+/+) or (+/-) for VDR Taq defect have lower Vitamin D levels, make less dopamine, and will need and tolerate dopamine precursor substances and methyl donors. With respect to methyl donor tolerance, VDR Taq (+) individuals behave like COMT (-) individuals. All sorts of permutations are possible here, impacting on your tolerance and need for dopamine precursors and methyl groups. I acknowledge that this is all very difficult to understand.

Tex: another interesting thing on this web page is the info about MTR & MTRR gene mutations.
if you have MTR A2756G mutation then your B12 blood levels may be normal, but your methyl B12 will be low.

then as you get into the MTRR, my interpretation of what the site says, based on my gene mutation results, is that i need both forms of B12.

I feel like Alice in Wonderland, what at first was really weird and strange, captivates me and is a magical world - where on the surface nothing makes sense, but then it makes more sense and I wonder why I didnt find this magical place earlier!!

[dfpowell]

Here is another website that allows you to download Dr. Amy Yasko's Autism book for free. It explains the methylation cycle in laymen's terms and includes supplementation. Dr Yasko's information is used on genetic genie.

http://www.holisticheal.com/autism-path ... y-esp.html

[tex]

I have a VDR Bsm mutation, but my VDR Taq gene is normal. Fortunately my MTR and MTRR genes are normal. But you're right. These genes affect how well we utilize these vitamins.

Tex

[ldubois7]

The more I know, the more I don't know....we are such complicated creatures!

[Gabes-Apg]

Linda,
Well said!!! Yes our bodies are a very delicate chemistry process...

This insight proves why in mc world one thing works for, but is hell for another...

Given your MTHFR status, this testing and data on the methylation cycle would be very helpful to your journey...

[ldubois7]

Gabes,

Yes, that was my question. Does the 23 & me give info on methylation and homocysteine? I'm simply not having success with my ND. She is compound hetero MTHFR, too, but has no issues, and therefore does not seem interested in my MTHFR related issues. :(

I'm reading a lot from Dr. Ben Lynch, but the more I read, the more confused I get about it all.

Thanks!

[tex]

Yes, that was my question. Does the 23 & me give info on methylation and homocysteine?

23andme mostly provides the raw data and ancestry information. We have to allow the GeneticGenie to run our raw data through their program to be able to see the actual genetic results that apply to the MTHFR issues (and homocysteine risks).

Tex

[Gabes-Apg]

Linda,

Yep, the 23andme data, put through genetic genie methylation report provides good basics on methylation,

If you then read through the info at the website I provided the link to above, it provides further info how gene mutations from the genetic genie report, there are about 25 of them, how your results are affecting the methylation cycle.

As mentioned, for me with my results I need both types of B12.

[Deb]

I am really grateful for this thread. There is a lot of information to try to discern.

I do not have MTHFR mutations

It has also been observed that
BH4 can also become depleted with a CBS upregulation. BH4 helps regulate
neurotransmitters and mood. Other mutations, such as MTHFR A1298C, Chronic
bacterial infections, and aluminum can also lead to low BH4 levels. Lack of BH4
can lead to mast cell degranulation and possibly mast cell activation disorder

MTR (5-methyltetrahydrofolate-homocysteine methyltransferase) provides
instructions for making the enzyme methionine synthase. Methionine synthase
helps convert the amino acid homocysteine to methionine. To work properly,
methionine synthase requires B12 (specifically in the form of methylcobalamin).
An MTR A2756G mutation increases the activity of the MTR gene causing a greater
need for B12 since the enzyme causes B12 to deplete since it is using it up at a
faster rate. Mutations in MTR have been identified as the underlying cause of
methylcobalamin deficiency. Megaloblastic anemia can occur as a consequence of
reduce methionine synthase activity.

A homozygous mutation of MTR A2756G is not very common (<1% of CEU population).
Some studies have demonstrated that people with a combination of MTHFR C677T and
MTR A2756G have persistently high homocysteine levels unless they are treated
with both B12 and folate.