Hi Wayne. I'm seeing my GI next week and would like to show him a study that states that PPIs weaken the LES. Unfortunately I can't find one.
Have you seen any you can direct me to? He will push PPIs on me but I want to explain that in time, off the PPI, my LES will strengthen on its own.
Thanks very much.
Wayne -- Looking for a Study to back me up
Moderators: Rosie, Stanz, Jean, CAMary, moremuscle, JFR, Dee, xet, Peggy, Matthew, Gabes-Apg, grannyh, Gloria, Mars, starfire, Polly, Joefnh
-
Gabes-Apg
- Emperor Penguin
- Posts: 8332
- Joined: Mon Dec 21, 2009 3:12 pm
- Location: Hunter Valley NSW Australia
This article has good references at the bottom that I think you are looking for
http://www.practiceupdate.com/content/t ... rt-i/17523
EDIT: the link wont work unless you do a google search
use the following wording to do a google search and you should be able to access it
The Use and Long-Term Risks of Proton Pump Inhibition
http://www.practiceupdate.com/content/t ... rt-i/17523
EDIT: the link wont work unless you do a google search
use the following wording to do a google search and you should be able to access it
The Use and Long-Term Risks of Proton Pump Inhibition
Gabes Ryan
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
Suzy,
I doubt that you will find any published research showing that PPIs weaken the clinching strength of the LES. No one seems to be inclined to research that characteristic of PPIs, but it's well known that the reduced use of any muscles causes them to weaken, and when PPIs are used, the lower acidity level tends to cause the LES to clinch less tightly (resulting in gradual atrophy over the long term). Besides, such an article would be very likely to inspire lawsuits against all the doctors who prescribe them, so I doubt that any medical researchers would be likely to pursue that research.
There are other reasons not to prescribe PPIs, though (because of all the health risks they cause (osteoporosis, magnesium deficiency, C. diff, SIBO, kidney disease, etc.)
Here are some good articles:
Do PPIs have long-term side effects?
Proton Pump Inhibitor Use and the Risk of Chronic Kidney Disease.
And here is an article about why PPIs cause the very symptoms that they are prescribed to treat:
Evidence That Proton-Pump Inhibitor Therapy Induces the Symptoms it Is Used to Treat
But the 9-page article at the link below is the one to show to your doctor, because this is one of the few medical websites that most doctors read and respect. You have to be registered in order to read articles on Medscape, but registration is simple (at least it was back when I registered there, years ago). This article describes in detail how PPIs cause each of the problems in this list. It was published back in 2010, so it doesn't include the research on PPIs causing chronic kidney disease (that was published this year):
Effects on Bone
Susceptibility to Infection
Clostridium difficile and other Enteric Infections
Pneumonia
Small Intestinal Bacterial Overgrowth
Spontaneous Bacterial Peritonitis
Enteric Malabsorption
Iron
Hypergastrinemia
Rebound Acid Hypersecretion
Impaired Gastric Emptying of Solids
Hypergastrinemia and Neoplasia
Carcinoid Tumors
Food Allergies and Eosinophilic Esophagitis
Effects on other Medications
Adverse Effects of Proton Pump Inhibitor Drugs: Clues and Conclusions
The fact that PPIs can cause food allergies and Eosinophilic Esophagitis is plenty reason by itself why MC patients should never take a PPI.
And here is a new article (published this year) that describes the mechanism by which PPIs cause heart attacks, kidney problems, and dementia/(possibly Alzheimer's)
Proton Pump Inhibitors Accelerate Endothelial Senescence
Tex
I doubt that you will find any published research showing that PPIs weaken the clinching strength of the LES. No one seems to be inclined to research that characteristic of PPIs, but it's well known that the reduced use of any muscles causes them to weaken, and when PPIs are used, the lower acidity level tends to cause the LES to clinch less tightly (resulting in gradual atrophy over the long term). Besides, such an article would be very likely to inspire lawsuits against all the doctors who prescribe them, so I doubt that any medical researchers would be likely to pursue that research.
There are other reasons not to prescribe PPIs, though (because of all the health risks they cause (osteoporosis, magnesium deficiency, C. diff, SIBO, kidney disease, etc.)
Here are some good articles:
Do PPIs have long-term side effects?
Proton Pump Inhibitor Use and the Risk of Chronic Kidney Disease.
And here is an article about why PPIs cause the very symptoms that they are prescribed to treat:
Evidence That Proton-Pump Inhibitor Therapy Induces the Symptoms it Is Used to Treat
But the 9-page article at the link below is the one to show to your doctor, because this is one of the few medical websites that most doctors read and respect. You have to be registered in order to read articles on Medscape, but registration is simple (at least it was back when I registered there, years ago). This article describes in detail how PPIs cause each of the problems in this list. It was published back in 2010, so it doesn't include the research on PPIs causing chronic kidney disease (that was published this year):
Effects on Bone
Susceptibility to Infection
Clostridium difficile and other Enteric Infections
Pneumonia
Small Intestinal Bacterial Overgrowth
Spontaneous Bacterial Peritonitis
Enteric Malabsorption
Iron
Hypergastrinemia
Rebound Acid Hypersecretion
Impaired Gastric Emptying of Solids
Hypergastrinemia and Neoplasia
Carcinoid Tumors
Food Allergies and Eosinophilic Esophagitis
Effects on other Medications
Adverse Effects of Proton Pump Inhibitor Drugs: Clues and Conclusions
The fact that PPIs can cause food allergies and Eosinophilic Esophagitis is plenty reason by itself why MC patients should never take a PPI.
And here is a new article (published this year) that describes the mechanism by which PPIs cause heart attacks, kidney problems, and dementia/(possibly Alzheimer's)
Proton Pump Inhibitors Accelerate Endothelial Senescence
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
This is the link I use. It should take you to a log in page and when you log in, the article should open.
http://www.medscape.com/viewarticle/730747
The link works fine for me. If you can't get the article to open there might be a problem with your browser or your account.
Tex
http://www.medscape.com/viewarticle/730747
The link works fine for me. If you can't get the article to open there might be a problem with your browser or your account.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.