Hello,
I wrote a few days ago on how my GI doc started me on Uceris and after 3 days I was feeling worse than I did before I started taking the pill. The strange thing is that when I started Uceris, (as well as budenoside with a different GI doc), I felt great the first 3 days of taking the pills, then on the fourth day, went downhill. When I took the budenoside, my doc told me that I should take the 3 pills all in the morning with breakfast. The Uceris was 9mg and I was told to take in the morning. I am just wondering, is it possible that the 9mg is just too much for my system and I would do better at a smaller dose? Or maybe take the budenoside at three separate times during the day = 3mg, breakfast lunch and dinner? Because I don't understand how I felt so good for a few days and then like clockwork on that 4th day, with both meds, I felt terrible. I stopped taking both pills after the 4th day because of the side effects - nausea as well.
Then I wonder, is it just a coincidence that on both occasions, my LC was just getting worse or was it the pills? Would the pills react that quickly on someone - after only taking 3 pills? Is it possible that taking one pill that day made me feel that good?
I'm just so confused because these doctors don't seem to have a clue on how to help. I feel like a guinea pig! I have been taking time from work and am thinking of taking an intermittent leave so that when the days are really unbearable, or if I need to leave early - I can do it without worrying about my job. It has become a daily struggle just to go to work and do my job.
Thank you for any advice you can give on the meds -
question on dosages of budenoside and users
Moderators: Rosie, Stanz, Jean, CAMary, moremuscle, JFR, Dee, xet, Peggy, Matthew, Gabes-Apg, grannyh, Gloria, Mars, starfire, Polly, Joefnh
Budesonide and other cortiocosteroids work relatively quickly to relieve the symptoms of MC, sometimes as soon as a day or two, but usually within a few days to a week. Usually, for most people, if it doesn't work within about two weeks, there's a good chance that it may not work at all. Corticosteroids supplement the naturally-produced cortisol in the body, which peaks in the mornings. Cortisol is what gives you the incentive to "embrace the new day" and be active, and when your cortisol level declines later in the day you tend to feel tired and low on energy. If you take a corticosteroid at any other time of day it sort of "messes up" (alters) that regular pattern in your normal routine. But the main point is that the corticosteroid will not have as much effectiveness when taken later in the day because it cannot take advantage of your normal cortisol cycle. It's designed, and best suited, to be taken first thing in the morning, not at any other time of the day, and not spaced out during the day.
There are indeed people who cannot tolerate the regular 9 mg dose of budesonide, and they do much better on 3 mg. I can recall at least two or three members in the past who were in that situation. So it's certainly possible that you might be also. But if that applies to you, the budesonide should be very effective (it should work quickly), and the 3mg dose should provide relatively good control.
A leave would probably be very beneficial, because if nothing else, it would relieve much of the stress, and stress is a huge MC trigger for many of us.
Tex
There are indeed people who cannot tolerate the regular 9 mg dose of budesonide, and they do much better on 3 mg. I can recall at least two or three members in the past who were in that situation. So it's certainly possible that you might be also. But if that applies to you, the budesonide should be very effective (it should work quickly), and the 3mg dose should provide relatively good control.
A leave would probably be very beneficial, because if nothing else, it would relieve much of the stress, and stress is a huge MC trigger for many of us.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Yes, I was prescribed Budenoside from the first GI doc - who gave me the 3-9mg tablets to take each morning. I felt great for 2 days then went downhill. This new GI doc that I'm going to gave me Uceris - 9mg tablet. Again, I felt great the first two days and then went downhill again. So I was wondering if it had to do with the dose. When I had told the first doc that my symptoms got worse, he wanted to give me antibiotics as he said if the Budenoside didn't work, I probably had in infection. But I didn't trust him, as he said, "I 'probably' had an infection" he didn't seem to be sure.
Tex, can you direct me to the person who would be able to assist me in getting the tests from Enterolab - as I live in New York and we are not allowed to order these tests.
Tex, can you direct me to the person who would be able to assist me in getting the tests from Enterolab - as I live in New York and we are not allowed to order these tests.
Well, I don't really have the right to volunteer the services of someone else, but Jean (JFR) might be willing to help you with the test kit. I'm not sure how often she logs in, but if she doesn't notice this thread within a day or so, you might sent her a PM to see if her location would be convenient for receiving a kit for you.
Tex
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
No, the skin tests and blood tests used by allergists are based on IgE and IgG antibodies in the skin and in the blood. They are of very little value for treating MC, because the correlation is poor. The antibodies produced by the immune system in response to food sensitivitioes are IgA antibodies found in the intestines and in stool. Being allergic to a food is not the same as being intolerant. MC is perpetuated by food intolerances.
If you react within less than 10 or 15 minutes after beginning a meal, that's an Ig-E-based reaction (a histamine-based reaction), and it means that you are allergic to something you ate. For that, an IgE antibody test like the ones used by allergists would be helpful. But if the reaction comes 2 or more hours after eating, that's an IgA-based reaction and it's a food intolerance.
Tex
If you react within less than 10 or 15 minutes after beginning a meal, that's an Ig-E-based reaction (a histamine-based reaction), and it means that you are allergic to something you ate. For that, an IgE antibody test like the ones used by allergists would be helpful. But if the reaction comes 2 or more hours after eating, that's an IgA-based reaction and it's a food intolerance.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.