hi :)
I apologize for dropping in and asking, but : can anyone help me interpret this. I'm a novice and need help....
Gene & Variation rsID Alleles Result
COMT V158M rs4680 AA +/+
COMT H62H rs4633 TT +/+
COMT P199P rs769224 GG -/-
VDR Bsm rs1544410 CT +/-
VDR Taq rs731236 AG +/-
MAO A R297R not found n/a not genotyped
ACAT1-02 not found n/a not genotyped
MTHFR C677T rs1801133 GG -/-
MTHFR 03 P39P not found n/a not genotyped
MTHFR A1298C rs1801131 GT +/-
MTR A2756G rs1805087 AA -/-
MTRR A66G rs1801394 AG +/-
MTRR H595Y not found n/a not genotyped
MTRR K350A rs162036 AG +/-
MTRR R415T rs2287780 CC -/-
MTRR A664A not found n/a not genotyped
BHMT-02 rs567754 CT +/-
BHMT-04 not found n/a not genotyped
BHMT-08 not found n/a not genotyped
AHCY-01 not found n/a not genotyped
AHCY-02 not found n/a not genotyped
AHCY-19 not found n/a not genotyped
CBS C699T rs234706 AG +/-
CBS A360A not found n/a not genotyped
CBS N212N not found n/a not genotyped
SHMT1 C1420T rs1979277 AA +/+
[/url]
Help with Genetic Genie
Moderators: Rosie, Jean, CAMary, moremuscle, JFR, Dee, xet, Peggy, Matthew, Gabes-Apg, grannyh, Gloria, Mars, starfire, Polly, Joefnh
Hi,
Welcome to the group. I'm certainly no expert, but these look like generally favorable results to me. The most important results (for MC patients) are those related to compromised methylation (which can cause high homocysteine levels, and other problems such as not being able to convert vitamins into the active form so that the body can use them). Looking at your results, your MTHFR C677T result shows no mutation (so no problem), and your MTHFR A1298C result indicates that this gene is compromised only about 30 % (which is usually not enough to cause any major problems).
The other genes (associated with breaking down various neurotransmitters) might cause problems in certain individuals, but normally, they shouldn't be a problem (even when the results are positive). This is a rather complex area that I know very little about because I don't consider it to be particularly important for most of us, anyway.
I hope that this is helpful.
Tex
Welcome to the group. I'm certainly no expert, but these look like generally favorable results to me. The most important results (for MC patients) are those related to compromised methylation (which can cause high homocysteine levels, and other problems such as not being able to convert vitamins into the active form so that the body can use them). Looking at your results, your MTHFR C677T result shows no mutation (so no problem), and your MTHFR A1298C result indicates that this gene is compromised only about 30 % (which is usually not enough to cause any major problems).
The other genes (associated with breaking down various neurotransmitters) might cause problems in certain individuals, but normally, they shouldn't be a problem (even when the results are positive). This is a rather complex area that I know very little about because I don't consider it to be particularly important for most of us, anyway.
I hope that this is helpful.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.