Hi everyone,
If I read the results corrrectly, it appears that I have two genes for gluten sensitivity. This really clinches my initial diagnosis 4 years ago, and helps me stay gf, even though I'm an asymptomatic case! The genes that I have are HLA- DQ3 and HLA-DQ1.
Love,
Alice
Enterolab results
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Alice,
Know what you mean about that feeling of confirmation.
If I remember correctly, the DQ 8 gene is sort of like a subtype of the DQ3, so can you tell whether that's the subtype that you have? This might be a good one to e-mail enterolab if you can't tell from your results.
I forgot, did you originally have damage to your small bowel -- like tTg antibody, and fecal fat? Reason for asking is that if your DQ3 is DQ8 subtype, then that's the second most common gene for the regular celiacs.
Am I confusing or what? Anyway, ask Dr. Fine if your DQ3 is also DQ8, which typically predisposes to celiac disease, if you want to know.
I'm always interested in the outcome of our tests. Do you plan on passing on this information to your kin?
Know what, Alice, I'm beginning to think that unless we are from SubSaharan Africa or the middle of China somewhere, that we're going to have genes that can lead to gluten sensitivity. Otherwise, our genes are sooo pooled now, that no one escapes them, it seems. It's really amazing how widespread gluten sensitivity can be.
Ultimately, I believe that there will be published a study showing genetic markers, at least, for every one of the food sensitivities that we tend to have, and thus, we'll know that the same ones will tend to show up in folks from the same families.
For instance, my sister and I are identical in terms of allergies, and only have a slight subtype difference in the same gene from one parent, my dad.
On the other hand, we each got one CD2 gene from Mom who turned out to have two CD2 genes, and ONLY a slight gluten sensitivity according to the reference points from the lab. Still it is elevated. Since my dad was already deceased, due to the genotypes of the three of us for the HLA genes, we were able to figure out what genes my dad must've had. He had two very similar genes, and gave one of each of them to my sister and me. Both of these apparently are M.C. genes. A match made in heaven in lots of ways, but probably not so good for the gut! Ha!
Hope this will be a good year for you, Alice!
How are you getting along these days?
Yours, Luce
Know what you mean about that feeling of confirmation.
If I remember correctly, the DQ 8 gene is sort of like a subtype of the DQ3, so can you tell whether that's the subtype that you have? This might be a good one to e-mail enterolab if you can't tell from your results.
I forgot, did you originally have damage to your small bowel -- like tTg antibody, and fecal fat? Reason for asking is that if your DQ3 is DQ8 subtype, then that's the second most common gene for the regular celiacs.
Am I confusing or what? Anyway, ask Dr. Fine if your DQ3 is also DQ8, which typically predisposes to celiac disease, if you want to know.
I'm always interested in the outcome of our tests. Do you plan on passing on this information to your kin?
Know what, Alice, I'm beginning to think that unless we are from SubSaharan Africa or the middle of China somewhere, that we're going to have genes that can lead to gluten sensitivity. Otherwise, our genes are sooo pooled now, that no one escapes them, it seems. It's really amazing how widespread gluten sensitivity can be.
Ultimately, I believe that there will be published a study showing genetic markers, at least, for every one of the food sensitivities that we tend to have, and thus, we'll know that the same ones will tend to show up in folks from the same families.
For instance, my sister and I are identical in terms of allergies, and only have a slight subtype difference in the same gene from one parent, my dad.
On the other hand, we each got one CD2 gene from Mom who turned out to have two CD2 genes, and ONLY a slight gluten sensitivity according to the reference points from the lab. Still it is elevated. Since my dad was already deceased, due to the genotypes of the three of us for the HLA genes, we were able to figure out what genes my dad must've had. He had two very similar genes, and gave one of each of them to my sister and me. Both of these apparently are M.C. genes. A match made in heaven in lots of ways, but probably not so good for the gut! Ha!
Hope this will be a good year for you, Alice!
How are you getting along these days?
Yours, Luce
Alice
Receiving the results from Dr. Fine’s Entero Labs was a life changing event. Thankfully for the better. It was a real confirmation of what I had to do to be , do, and have wellness. I find it very interesting how late in life symptoms occurred in that I discovered through the testing that I have both of the main genes that predispose to gluten sensitivity and celiac sprue (HLA-DQ2 and HLA-DQ8) and that this genotype also can predispose to microscopic colitis. I would never have dreamed that I was gluten sensitive earlier in my life since I ate gluten containing grains without limits and never had a problem untill something set it off.
If I had only known. HaHaHa. 20/20 hindsight.
Your being asymptomatic is always an inspiration.
Matthew
Receiving the results from Dr. Fine’s Entero Labs was a life changing event. Thankfully for the better. It was a real confirmation of what I had to do to be , do, and have wellness. I find it very interesting how late in life symptoms occurred in that I discovered through the testing that I have both of the main genes that predispose to gluten sensitivity and celiac sprue (HLA-DQ2 and HLA-DQ8) and that this genotype also can predispose to microscopic colitis. I would never have dreamed that I was gluten sensitive earlier in my life since I ate gluten containing grains without limits and never had a problem untill something set it off.
If I had only known. HaHaHa. 20/20 hindsight.
Your being asymptomatic is always an inspiration.
Matthew
Hi Lucy and Matt,
My subtypes are DQ5 and DQ7 - which are not the ones for celiac, if I'm reading this right. But just knowing that I have the ones for gluten sensitivity makes if easier to stay gf. However, I had no intention of going off the diet because I've been in remission from MC for 4 years!
Luce, I tested positive for malabsorption 4 years ago - intestinal damage
according to the fecal fat test. When I was retested a year later, the damage was greatly healed, although not entirely, but enough to validate
my need to be gf.
I don't entirely understand the genotype findings - is it correct that one can have two of the same gene - say DQ3 (one from each parent) or two different genes - DQ3 and DQ1 like I have? And in both cases this means greater likelihood of gluten sensitivity?
This is a fascinating subject - it would be interesting if everyone here could get the gene test and we could compare. I wonder if there would be great similarities?
Alice
My subtypes are DQ5 and DQ7 - which are not the ones for celiac, if I'm reading this right. But just knowing that I have the ones for gluten sensitivity makes if easier to stay gf. However, I had no intention of going off the diet because I've been in remission from MC for 4 years!
Luce, I tested positive for malabsorption 4 years ago - intestinal damage
according to the fecal fat test. When I was retested a year later, the damage was greatly healed, although not entirely, but enough to validate
my need to be gf.
I don't entirely understand the genotype findings - is it correct that one can have two of the same gene - say DQ3 (one from each parent) or two different genes - DQ3 and DQ1 like I have? And in both cases this means greater likelihood of gluten sensitivity?
This is a fascinating subject - it would be interesting if everyone here could get the gene test and we could compare. I wonder if there would be great similarities?
Alice
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Thanks so much for starting the conversation about Dr. Fine's testing. I intend to get it done; so you posting your results was a reminder to me to save my $$. Love, Marsha
Alice,
It is highly possible to have a gene from your dad which is exactly like the one your mom gave you. For instance, my mom got one HLA-DQ2 gene from her dad, and another from her mom.
I wasn't kidding before when I mentioned that, due to genetic pooling over the millenia, it's almost impossible NOT to have a gene that predisposes to gluten sensitivity.
Brought this up once before, but I read one time on a Promethius lab site that they have a test that will break down the DQ-2 into two types, and think it said that only one of them produced the Gold-Standard defined Celiac Disease among the DQ-2 carriers.
They didn't say what the other form would do in a person.
I've always been curious as to whether Mom has one or both of this type, and if she only has one that's the CD one, then that would make me want to check mine out, if I had nothing else to do with my $$$. Suppose I could just do mine, and perhaps my sister would do it too, and if our CD2's differed, then we could figure out that Mom had one of each. Naw, not worth the $$$ cause already know we're gluten sensitive.
Would have to look way back in my files to find the other gene from my dad, and can't get to that right now, but hopefully, soon.
Alice, it's interesting that Sis and I have the same allergens, and similar gene pair, and also, our member, Rita from Mass., has the same genes and allergens as well. This must be what Dr. Fine was talking about -- each allergen is genetically determined.
It's just a hunch, but my guess is that which parts of the gut are disturbed the most by these sensitivities are also genetic determined. Guess everything is, so that's why we're all so different.
Genetics is fascinating!
Yours, Luce
It is highly possible to have a gene from your dad which is exactly like the one your mom gave you. For instance, my mom got one HLA-DQ2 gene from her dad, and another from her mom.
I wasn't kidding before when I mentioned that, due to genetic pooling over the millenia, it's almost impossible NOT to have a gene that predisposes to gluten sensitivity.
Brought this up once before, but I read one time on a Promethius lab site that they have a test that will break down the DQ-2 into two types, and think it said that only one of them produced the Gold-Standard defined Celiac Disease among the DQ-2 carriers.
They didn't say what the other form would do in a person.
I've always been curious as to whether Mom has one or both of this type, and if she only has one that's the CD one, then that would make me want to check mine out, if I had nothing else to do with my $$$. Suppose I could just do mine, and perhaps my sister would do it too, and if our CD2's differed, then we could figure out that Mom had one of each. Naw, not worth the $$$ cause already know we're gluten sensitive.
Would have to look way back in my files to find the other gene from my dad, and can't get to that right now, but hopefully, soon.
Alice, it's interesting that Sis and I have the same allergens, and similar gene pair, and also, our member, Rita from Mass., has the same genes and allergens as well. This must be what Dr. Fine was talking about -- each allergen is genetically determined.
It's just a hunch, but my guess is that which parts of the gut are disturbed the most by these sensitivities are also genetic determined. Guess everything is, so that's why we're all so different.
Genetics is fascinating!
Yours, Luce
Lucy,
Dr. Fine says that about 81% of us have a gluten sensitivity gene. That's just about everyone, as you said! So, what do you think is the variable (s) that makes some of us get MC, but not others? Is it another subtype
or a conbination of certain genes? I know there is a trigger factor also.
But still, the population with MC "seems" to be far less than the 81% who have the gene. Thanks for answering my question about duplicate genes from each parent!
Alice
Dr. Fine says that about 81% of us have a gluten sensitivity gene. That's just about everyone, as you said! So, what do you think is the variable (s) that makes some of us get MC, but not others? Is it another subtype
or a conbination of certain genes? I know there is a trigger factor also.
But still, the population with MC "seems" to be far less than the 81% who have the gene. Thanks for answering my question about duplicate genes from each parent!
Alice
Could be that there are other genes involved other than just these markers. Pretty sure that most things involve more than one gene.
Still, like you said, there are the triggers to the autoimmune process which apparently kick the whole thing off in the first place.
Who knows for sure what all that entails?
I believe that what the genes do is produce the right proteins that respond to specific cells they attack when they mistake them for foreign protein that is harmful to the body, or, in this case, certain tissues of the colon.
These cells produced by the relevant genes are part of the body's immune system, but instead of attacking a foreign protein, they attack a protein in their own organism.
To make a long story short, there are similarities in the foreign protein and that of a part of one's body such that the immune system mistakenly "recognizes" it's own protein as foreign.
Wow, getting sleepy again.
Yours, Luce
Still, like you said, there are the triggers to the autoimmune process which apparently kick the whole thing off in the first place.
Who knows for sure what all that entails?
I believe that what the genes do is produce the right proteins that respond to specific cells they attack when they mistake them for foreign protein that is harmful to the body, or, in this case, certain tissues of the colon.
These cells produced by the relevant genes are part of the body's immune system, but instead of attacking a foreign protein, they attack a protein in their own organism.
To make a long story short, there are similarities in the foreign protein and that of a part of one's body such that the immune system mistakenly "recognizes" it's own protein as foreign.
Wow, getting sleepy again.
Yours, Luce
Alice,
That was a lonnnnng, lonnnng time ago that I was trained in science, but I think that reading so many research papers in the past, makes it a little easier to follow some of the things I read now, not that I'm reading more than things written for lay people lately.
I started out as a biologist many, many years ago, but ended up working as a scientist in one of the cardiovascular labs (there were two of them) at NASA/MSC shortly after the Apollo 13 flight. (Think this was about 1970-'72.)
This was a physiology lab, so it was not really my main field of interest, but it was one of the highlights of my working life. I later branched out into some other fields, but I always enjoyed the sciences, I'm just not good at remembering things, so most of it is pretty well erased from my memory by now.
Back in those days, we had a computer programmer to do all the computer work, so I never really had to get too deep into that part of it. I actually knew more about em before they became "user friendly" than I do now, which is almost nothing! Plan on taking that up once the caregiving days are over. May be too old for anyone to hire then, but don't want the computer illiteracy thing to be a hindrance.
All this way of labelling genes today, etc., is something I've only recently learned about, but I'd love to know more if I had time to study it.
Thanks for the compliment, though.
How are you doing lately, Alice?
Yours, Luce
That was a lonnnnng, lonnnng time ago that I was trained in science, but I think that reading so many research papers in the past, makes it a little easier to follow some of the things I read now, not that I'm reading more than things written for lay people lately.
I started out as a biologist many, many years ago, but ended up working as a scientist in one of the cardiovascular labs (there were two of them) at NASA/MSC shortly after the Apollo 13 flight. (Think this was about 1970-'72.)
This was a physiology lab, so it was not really my main field of interest, but it was one of the highlights of my working life. I later branched out into some other fields, but I always enjoyed the sciences, I'm just not good at remembering things, so most of it is pretty well erased from my memory by now.
Back in those days, we had a computer programmer to do all the computer work, so I never really had to get too deep into that part of it. I actually knew more about em before they became "user friendly" than I do now, which is almost nothing! Plan on taking that up once the caregiving days are over. May be too old for anyone to hire then, but don't want the computer illiteracy thing to be a hindrance.
All this way of labelling genes today, etc., is something I've only recently learned about, but I'd love to know more if I had time to study it.
Thanks for the compliment, though.
How are you doing lately, Alice?
Yours, Luce
Hi All!
I just came across something while reading one of the Journal Of Longevity magazines that my husband receives about every 3 months.
There is an article in there talking about Food Allergies and Blood Type.
It states that everyone should know their blood type in case of an emergency, but also to protect your self against food allergies, which are often blood/type specific.
After 20 years of research, 5 "bio-type diets have been developed that may help to avoid the allergies that are most common to a specific blood type. Examples: Type A1 , the most common allergies, (mostly delayed) are caused by eggs and other dairy products. The best diet to follow would be the Mediterranean. Blood type A2, has fairly similiar allergies, but unlike A1, it can react to gluten grains. The best diet would be Scandinavian, which features plenty of seafood. Blood type B, males are more allergic than females, and tend to react to nuts, beans,and gluten grains more than other foods, and the best diet would be Asian. For Blood type AB, the worst allergens are cashews, soy, and egg whites.
For Blood type 0, the worst allergens are milk, eggs, chese. and corn syrup...
I found this to be pretty interesting and thought others might too!
Love
Dee~~~~
I just came across something while reading one of the Journal Of Longevity magazines that my husband receives about every 3 months.
There is an article in there talking about Food Allergies and Blood Type.
It states that everyone should know their blood type in case of an emergency, but also to protect your self against food allergies, which are often blood/type specific.
After 20 years of research, 5 "bio-type diets have been developed that may help to avoid the allergies that are most common to a specific blood type. Examples: Type A1 , the most common allergies, (mostly delayed) are caused by eggs and other dairy products. The best diet to follow would be the Mediterranean. Blood type A2, has fairly similiar allergies, but unlike A1, it can react to gluten grains. The best diet would be Scandinavian, which features plenty of seafood. Blood type B, males are more allergic than females, and tend to react to nuts, beans,and gluten grains more than other foods, and the best diet would be Asian. For Blood type AB, the worst allergens are cashews, soy, and egg whites.
For Blood type 0, the worst allergens are milk, eggs, chese. and corn syrup...
I found this to be pretty interesting and thought others might too!
Love
Dee~~~~
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Hi Dee,
I wanted to thank you for mentioning the allergy article, also. You said it was from the Journal of Longevity, but does it say who the research was done by, or who the article was by? I'm just curious, because this sounds like it's maybe a more reputable source than where some of the blood type information comes from. Thanks, Marsha
I wanted to thank you for mentioning the allergy article, also. You said it was from the Journal of Longevity, but does it say who the research was done by, or who the article was by? I'm just curious, because this sounds like it's maybe a more reputable source than where some of the blood type information comes from. Thanks, Marsha