How many of us have methylation issues?

[tex]

I wonder how many of us have methylation issues due to MTHFR gene mutations. If you've had 23andme gene testing, please select the most appropriate response in the poll. Thanks.

Tex

[Gabes-Apg]

I have reviewed my full methylation profile.
Testing showed I had no issues with the two common MTHFR genes, C677 A1298.


Within the methylation profile the gene variations causing my issues were
COMT
MAO-A
BHMT 02
BHMT 08
VDR Bsm
VDR Tap
CBS

[dps231]

I have MTHFR, the c677T homozygous variant. I discovered it a week ago after testing with 23andme.
As I said in another topic, I'm trying to figure out what is the connection with MC, Histamine issues and Depression/Anxiety (serotonin production).
For me, this makes a lot of sense, because during my whole life I've suffered from anxiety, being dependant on antidepressants (It seems that neurotransmitter production needs B group vitamins).
I also suffered from asthma, MASSIVE pollen allergy, eczema, etc. since I was a child. (Gabes's story reminds me of mine)

The last piece of the puzzle is MC:
In addition to SSRI as an important causative, I wonder if methylation has also something to do with MC, because my history says that my gi symptoms improve noticeably when using antihistamines (mirtazapine for example).

Tex, I can see because of your messages (eg. https://www.perskyfarms.com/phpBB/viewt ... on#p167053 or https://www.perskyfarms.com/phpBB/viewtopic.php?t=21137) that you are also suspecting something about this possible connection.

What do you guys think? Maybe I'll find an MC improvement if I improve methylation cycle, don't you think?

I ordered a seeking health supplement with active B vitamins.

[tex]

Growing up, I had most of the health problems that you mentioned. My Genetic Genie analysis shows that my MTHFR gene mutations are similar to Gabes', Except that also have the C677 and A1298 mutations. Most of mine are heterozygous, except for the VDR-Bsm and MAO-A R297R mutations, which are homozygous. Probably the main reason why I believe there's a connection with MC is because mutations such as the VDR genetic mutations cause us to be vitamin D deficient, and vitamin D deficiency can make our immune system so week that it's almost useless, if The deficiency of vitamin D (or magnesium) is bad enough.

But there are plenty of connections with other diseases or syndromes, also. For example, my homozygous MAO-A R297R issue caused a neurologist to misdiagnose me with Parkinson's disease about 12 1/2 years ago, because this defect caused me to have balance, reflex, and gait issues that are diagnostic of Parkinson's disease. Fortunately, I don't have Parkinson's disease, although I certainly had the symptoms before I started taking the proper "B" vitamin supplements that I needed. I still take them, and now my blood labs look good.

I resolved my issues by taking a prescription only product known as Metanx. Metanx is prescribed to treat neurological issues that are common among diabetes patients, and it contains the proper balance of B vitamins that we need, in the active forms. Interestingly, my doctor (my GP) at the time was in his upper 70s, and he mentioned that he was taking Metanx in order to support his cognizance and memory. After the Obamacare legislation was passed, Metans became so expensive that I switched to a generic product by Thorne Laboratories, known as Methyl Guard Plus. it seems to work just as well, at a much lower cost, and it's readily available over the counter. I order mine from Amazon. Many members of this forum apparently take this product or a reduced dose version called simply Methyl Guard, also from Thorne Laboratories.

I hope this helps.

Tex

[Mhdbeachgirl]

Hi: Has anyone tried the other brands of methylation support supplements besides Thorne? Such as Pure or Neurobiogenesis. Thorne is pricey and I am looking for less pricey alternatives without sacrificing quality. Can't help it! I am a thrifty New Englander!

[tex]

Are you sure you're making a fair comparison? The sites I looked at showed the Pure brand to be one dollar higher than Thorne for the same number of capsules, and Thorn Methyl Guard Plus contains five times the amounts of the active vitamins, and vitamins that the Pure brand doesn't even contain. But I only did one quick comparison, so maybe I looked at the wrong sites.

Tex

[Gabes-Apg]

In regards to supplements - you get what you pay for.

Cheaper version either have lower doses (in the fine print on the label) and/or less ideal fillers.

[Linda in BC]

Hi Everyone.. I have not been on here in a coon' s age. I have been in remission of my MC for about 6 or 7 years now. For those of you who don't know me or remember me here, it was severe for 17 years, with me eventually down to being able to eat only about 8 foods I posted a while back about what I attribute my remission to and it was dealing with my MTHFR and other mutation issues. This was specifically my inability to process B vitamins in most forms, which then caused blocked methylation pathways and an inability to process sulphur, resulting in a buildup of homocysteine in my system. I took 3 Thorne Methylguard Plus a day for almost 3 years, during which I saw a very slow but steady improvement in my symptoms. At the point that I just had food reactions occasionally, I also quit smoking. I took Zyban to do this , and I noticed that while on Zyban the diarrhea stopped completely but resumed when I stopped. So this made me suspect a final serotonin imbalance and I decided to try one 30 mg 5http ( the precursor needed for serotonin production) cap a day. I am happy to report that I have been pretty much symptom free and in remission now for the last 5 years. I was still taking the Methylguard Plus 3 times a day for quite a while but my lab work came back saying my b vitamin levels were in the 4,000s (LOL!) so I stopped. When symptoms started to creep back I resumed but just with one regular Methylguard cap (not Mehtylguard Plus) a day. Recently I was slipping again so I increased it to two regular Methylguards a day and am fine again. My colitis is definitely caused by a methylation issue and I will be forever grateful that I was able to figure this out and get my life back! I hope my telling about my journey to health may help someone else who is similarly afflicted.

Hello and Cheers to all the "oldtimers" from my past time on here !
Linda

[tex]

Hello Linda,

Good to see a post from you again, especially one that mentions that you're still doing well after so many years of dealing with these health issues.I noticed in the past, that those vitamin B tests don't seem to work properly for those of us who have methylation issues. The tests often show that we have extremely high levels of the vitamins, when actually, our body is starving for the active forms of those vitamins. I don't have any idea why the tests are so inaccurate, but that seems to be the case, at least for many of us.

I started taking Metanx (the prescription form that preceded the Thorne generics) about 15 years ago. But when Obama care was passed, Metanx became increasingly expensive, and so I switched to one methyl guard plus capsule per day, and I continue to take one per day, and so far, I haven't noticed any problems.

Good to hear from you again

Tex