Genetic study of celiac disease

[Carrie]

This is abstracted from the Columbia Genome Center web page:

Genetic study of celiac disease. Celiac disease (gluten-sensitive enteropathy) is a common multifactorial disorder resulting from intolerance to gluten, the major seed storage protein common to wheat, barley and rye. Part of an individual's genetic susceptibility to celiac disease is due to inheritance of one or several HLA DQ alleles, however, the majority of genetic susceptibility arises from unknown gene variants. We are collaborating with clinical groups in Finland where we recently completed a whole genome DNA marker analysis of 60 families, each with at least two biopsy proven cases of celiac disease. . By a joint analysis of linkage and association, a LOD of 22 could be achieved for HLA DQ, assuming the penetrance of 0.6. Other hints of linkage throughout the genome are small, suggesting that other genetic factors may impart only small effects upon the disease. In collaboration with Dr. Wang (Functional Genomics), we are attempting to use whole genome gene expression to study the specific set of genes that are turned on or off in response to gluten induction in biopsy samples.

To view the site, go to http://genome4.cpmc.columbia.edu/resear ... lliam.html and scroll down.