She is doing blood test for Celiac Disease!!!!!!!!!!!!!!!!!!!Quite sceptical of EL, of course.
Regular doctor's appointment
Moderators: Rosie, Stanz, Jean, CAMary, moremuscle, JFR, Dee, xet, Peggy, Matthew, Gabes-Apg, grannyh, Gloria, Mars, starfire, Polly, Joefnh
Regular doctor's appointment
She is doing blood test for Celiac Disease!!!!!!!!!!!!!!!!!!!Quite sceptical of EL, of course.
DISCLAIMER: I am not a doctor and don't play one on TV.
LDN July 18, 2014
Joan
LDN July 18, 2014
Joan
Joan,
Diagnosing Celiac Disease
The pathophysiology of celiac disease involves an immune reaction in the mucosa of the small intestine. Ingested gluten from wheat, rye, and barley induces an inflammatory reaction in the lamina propria, leading to symptoms. Although there is no single means to diagnose celiac disease, a review article from 2007 proposed a diagnostic algorithm to help clinicians.[5] Gliadin antibodies were previously used to test for celiac disease, however, they are no longer used because of their poor sensitivity and specificity. Rather, serologic testing remains a good initial examination in the evaluation of celiac disease and should focus on immunoglobulin (Ig)A endomysial antibody or IgA tissue transglutaminase (tTG) antibody, which have been demonstrated to have sensitivity and specificity values exceeding 95% for celiac disease.[6] Using both tests is rarely necessary, and the relatively lower price of the tTG antibody test makes it a good choice for initial screening for celiac disease.
A positive tTG antibody test is insufficient to assure the diagnosis of celiac disease, and patients with such results should undergo small bowel biopsy. A negative tTG antibody test does not necessarily rule out celiac disease if a high suspicion for it exists. In such cases, a small bowel biopsy should also be considered. A negative small bowel biopsy should prompt reconsideration of diagnoses other than celiac disease, although a repeat biopsy may be indicated for patients with positive serologic testing. Genetic testing for histocompatibility leukocyte antigen (HLA)-DQ2 and HLA-DQ8 can also be useful in cases when the diagnosis of celiac disease is in doubt.[5] These genetic tests have a high sensitivity, so negative results make celiac disease much less likely.
Diagnosing Celiac Disease
The pathophysiology of celiac disease involves an immune reaction in the mucosa of the small intestine. Ingested gluten from wheat, rye, and barley induces an inflammatory reaction in the lamina propria, leading to symptoms. Although there is no single means to diagnose celiac disease, a review article from 2007 proposed a diagnostic algorithm to help clinicians.[5] Gliadin antibodies were previously used to test for celiac disease, however, they are no longer used because of their poor sensitivity and specificity. Rather, serologic testing remains a good initial examination in the evaluation of celiac disease and should focus on immunoglobulin (Ig)A endomysial antibody or IgA tissue transglutaminase (tTG) antibody, which have been demonstrated to have sensitivity and specificity values exceeding 95% for celiac disease.[6] Using both tests is rarely necessary, and the relatively lower price of the tTG antibody test makes it a good choice for initial screening for celiac disease.
A positive tTG antibody test is insufficient to assure the diagnosis of celiac disease, and patients with such results should undergo small bowel biopsy. A negative tTG antibody test does not necessarily rule out celiac disease if a high suspicion for it exists. In such cases, a small bowel biopsy should also be considered. A negative small bowel biopsy should prompt reconsideration of diagnoses other than celiac disease, although a repeat biopsy may be indicated for patients with positive serologic testing. Genetic testing for histocompatibility leukocyte antigen (HLA)-DQ2 and HLA-DQ8 can also be useful in cases when the diagnosis of celiac disease is in doubt.[5] These genetic tests have a high sensitivity, so negative results make celiac disease much less likely.
"What the heart gives away is never gone ... It is kept in the hearts of others."
Joan,
You do not have either one of the two most common types of celiac genes, so there is no way that you will ever show a positive response to a test for celiac disease. The odds against that happening are about a million to one, since you would have to have an extremely rare, (uncatalogued), celiac gene for that possibility to even exist. Here are your gene test results:
HLA-DQB1 Molecular analysis, Allele 1 0301
HLA-DQB1 Molecular analysis, Allele 2 0603
Serologic equivalent: HLA-DQ 3,1 (Subtype 7,6). Predisposes to gluten sensitivity and MC, but not celiac.
Your doctor is wasting time and money with that test, but at least it's a cheap, and easy test.
Tex
You do not have either one of the two most common types of celiac genes, so there is no way that you will ever show a positive response to a test for celiac disease. The odds against that happening are about a million to one, since you would have to have an extremely rare, (uncatalogued), celiac gene for that possibility to even exist. Here are your gene test results:
HLA-DQB1 Molecular analysis, Allele 1 0301
HLA-DQB1 Molecular analysis, Allele 2 0603
Serologic equivalent: HLA-DQ 3,1 (Subtype 7,6). Predisposes to gluten sensitivity and MC, but not celiac.
Your doctor is wasting time and money with that test, but at least it's a cheap, and easy test.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
NO Surprise
Her test came back negative. It's a good thing, too. I was a bit testy when I said, "I DO NOT have Celaic Disease."
DISCLAIMER: I am not a doctor and don't play one on TV.
LDN July 18, 2014
Joan
LDN July 18, 2014
Joan