I wouldnt do anything different to the Magnesium and Vit B6 (aka P5P) - both are key in managing histamine levels and are MC safe.
any of the other products/food ingredients that may reduce histamine could be an issue MC wise.
if you really want to try things that will help reduce histamine from the suggestions below
NAC is a possible option ( i have used that for liver support while i am clearing toxic copper and tolerated it ok)
TMG is another
I never tolerated or benefited from Quercertin or bromelain.
hope this helps
http://acidicbody.com/histamine-toxicit ... histamine/
Correcting nutritional imbalances responsible for histamine control
Mineral hair analysis is a helpful test to measure the minerals excretion from a body and thus an indicator of mineral content within the tissues. Referring to the test results of a hair mineral analysis, the following minerals are important to have properly balanced
Calcium – appears to have a regulatory role, limiting the histamine secretion [srs]. Calcium also helps to mobilize histamine from tissues. If calcium supplements are taken, the total dietary consumption along with calcium supplements should not exceed 1500mg a day. If you have hypercalcemia, calcium supplements are strictly contraindicated.
Magnesium – regulates activity of histidine decarboxylase which is responsible in histamine production from histidine. Magnesium is also an important co-factor in DAO enzyme capacity
Chromium – stabilizes glucose metabolism, preventing stress and therefore reducing mast cell activity
Zinc - inhibits mast cells degranulation. Antagonizes copper. With pancreatic insufficiency may produce anxiety.
Manganese – inhibits mast cells degranulation and elevates diamine oxidase activity. Antagonizes copper
Copper – required for DAO enzyme capacity responsible for histamine breakdown from foods and in plasma
Zinc and Copper generally need to be supplemented in ratio of 8:1 if either one is taken
Reducing toxic levels of histamine
Most of the below supplements (except for herbs) should be taken 30-60 minutes before a meal to increase absorption.
Vitamin C (buffered, sustained release) - reduces mast cell histamine capacity and increases DAO enzyme activity
Usage: up to 1000mg daily in morning
Methionine (amino acid) – acts as as an anti-folate, adding a methyl group to help histamine mobilization
Usage: 500mg 3 times daily between meals in divided doses during flare up and 500-1000mg daily in divided doses for maintenance. Take 3-day breaks to keep the body’s ability to process methionine without supplementation.
Vitamin B6 – co-factor of DAO enzyme. Inhibits mast cell degranulation [srs]. With pancreatic insufficiency may produce anxiety.
Usage: 2-10mg daily (If tolerated. May create anxiety). Best taken once in morning with Methionine.
Glycine (amino acid) – inhibits histidine. Contraindicated with hypercalcemia.
Usage: 500-1000mg daily 2 hours after last meal. Produces calming effect, may slow down peristaltic movement and cause constipation.
TMG (Trimethylglycine) increases methionine levels and protects the cardiovascular system by neutralizing homocysteine
Usage: 500-1000mg daily in morning. Can be too stimulating.
Quercetin/Bromelain combo & lemon bioflavonoids – limit the histamine release from mast cells. This appears to be the most effective combo to use during an acute histamine release bout.
Usage: Quercetin and bromelain as a combo in one supplement is more effective. Take for 1-2 weeks then make a 2 week break. Not recommended long term.
Pycnogenol (French maritime pine extract, bioflavonoid) – significantly inhibits mast cells degranulation [srs]. May cause hot flashes.
Vitamin K2 (Menaquinone-7 /MK-7). Reduces mast cells degranulation by transferring the calcium that facilitates mast cells activation from blood serum into the bones.
Usage: 100mcg daily
N-acetyl-cysteine (NAC) – 200mg in morning to decrease excessive mucous and gently lifts intracellular glutathione for detoxification. NAC can also cause elevated baseline mast cells degranulation. Best taken with vitamin C to limit mast cell histamine capacity.
